Wound Healing Effects of HO/03/03 In Patients With Diabetic Neuropathic Plantar and Venous Ulcers, Pilot Study.

This is a multicenter pilot study to assess the healing effects of HO/03/03 on diabetic neuropathic plantar and venous ulcers.

HO/03/03 action mechanism involves the manipulation of keratinocyte and fibroblast migration and differentiation at the wound area.

• The primary end point of this study is assessment of safety in treating with HO/03/03 and the efficacy of the drug to promote wound closure of chronic wounds.
• The secondary end points are assessment time to closure and healing rate for the measurement of wound healing progression.

Study Overview

• Status: Completed
• Conditions: Diabetic Foot Ulcer; Venous Ulcer
• Intervention / Treatment: Drug: HO/03/03

Detailed Description

This is a multicenter pilot study to assess the healing effects of HO/03/03 on diabetic neuropathic plantar and venous ulcers.

Pretreatment phase: During a pretreatment phase that will last up to 14 days, all patients will receive the conventional treatment once a day at the discretion of the investigator. All wounds will be morphologically monitored by photo documentation daily and measurements of wound area once a week.

Initial study visit: patients will begin treatment after completing all necessary demands in pre-treatment phase or after ruling out of all exclusion criteria. All wounds will be cleaned from previous treatment by surgical debridement and irrigation (saline).

Treatment phase: Following the pre-treatment phase, wounds will be treated topically with HO/03/03 for 30 days. During this 30 day phase, patients will receive daily treatments with HO/03/03 either at home by a certified nurse or at the clinic. Wounds will be monitored by certified medical staff member as well as photo documentation. Then application of the treatment followed by a 15-minute rest. Finally wound will be dressed with a fresh dressing and monitoring of any adverse events.

Patients will be administered HO/03/03 in addition to weight off-load Once a week wounds will be monitored by a physician: wounds size will be determined and documented. Patients will be evaluated for pain sensation at the wound area by filling a pain scoring questionnaire.

Twice during the experiment patients will undergo blood profile, HbA1c, blood glucose, and urine samples testing at the initial and terminating visits.

At the conclusion of the treatment phase the following will be completed:

• A physical examination;
• Collection of all blood and urine samples for clinical laboratory tests (dip sticks);

• Study Type: Interventional
• Enrollment (Actual): 22
• Phase: Phase 1

Contacts and Locations

Study Locations

• Israel
  • Beer Yaakov, Israel, 70300
    • Assaf Harofe Medical Center
  • Jerusalem, Israel
    • Hadassah Ein Kerem Medical Center
  • Rechovot, Israel
    • Kaplan Medical Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

Patients must satisfy all of the following inclusion criteria to be included in the study:

1. be male or female over the age of 18;
2. have a diabetic neuropathic plantar and/or venous ulcer;
3. wound diameter <10cm;
4. wound depth is no more than exposed muscle;
5. have a current physical examination, which reveals no clinically significant abnormalities, except diabetes or diabetic ulcer/wound related condition
6. be available for the entire study period, and be able and willing to adhere to protocol requirements;
7. vascular inflow as measured by Doppler: ABI >= 0.7
8. have a debilitating wound over a period of 1 month prior to the experiment;
9. if female of childbearing potential, must be using a reliable form of birth control;
10. provide written informed consent prior to admission into the study.

Exclusion Criteria:

Patients will be excluded from the study if they meet any of the following exclusion criteria:

1. have a body mass index (BMI) > 45;
2. have a glycosylated hemoglobin (HbAlc) > 12.0%;
3. have a history or presence of HIV or a clinically significant cardiac, gastrointestinal, endocrine, neurological, liver, or kidney disease;
4. have any clinically significant illness during the 4 weeks prior to admission into the study, except diabetes type1 or type2;
5. patients on concomitant medications that alter blood glucose levels (e.g., ACE inhibitors, lipid lowering agents, etc) must be on a stable dosage regimen for at least 4 weeks prior to entry into the study and the dosage must remain stable throughout the study;
6. patients on chemotherapy;
7. participation in a clinical study or use of an investigational drug within 30 days prior to admission to this study;
8. are pregnant or lactating;
9. visible bone exposure at wound site;
10. have any signs of clinical infection in the wound (which could be linked to raised body temperature), necrosis, erythema or mild drainage;
11. have any acute illness within 2 weeks prior to Screening;
12. residing in a nursing facility and/or are bed-ridden (unable to come to receive treatment at the clinic);

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Treatment arm; One Arm - Active Compound (HO/03/03)	Drug: HO/03/03

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Safety	Treatment Period

Secondary Outcome Measures

Outcome Measure	Time Frame
Time to Heal & Rate of Healing	Treatment Period

Collaborators and Investigators

• Sponsor: HealOr
• Investigators: Principal Investigator: Micha Rapoport, Dr., Assaf Harofe Medical Center; Principal Investigator: Leon Gilead, Dr., Hadassah Ein Kerem Medical Center; Principal Investigator: Zvi Landau, Dr., Kaplan Medical Center

Study record dates

Study Major Dates

• Study Start: June 1, 2006
• Study Completion (Actual): May 1, 2007

Study Registration Dates

• First Submitted: June 19, 2006
• First Submitted That Met QC Criteria: June 19, 2006
• First Posted (Estimate): June 20, 2006

Study Record Updates

• Last Update Posted (Estimate): August 17, 2007
• Last Update Submitted That Met QC Criteria: August 16, 2007
• Last Verified: August 1, 2007

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Cardiovascular Diseases; Vascular Diseases; Skin Diseases; Endocrine System Diseases; Diabetic Angiopathies; Leg Ulcer; Skin Ulcer; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Foot Diseases; Varicose Veins; Diabetic Foot; Foot Ulcer; Ulcer; Varicose Ulcer
• Other Study ID Numbers: HO-01-05