- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00678028
Association Between Deficiency of MBL (Mannose-Binding Lectin) and Polymorphisms in MBL2 Gene to Urinary Tract Infection
April 22, 2009 updated by: HaEmek Medical Center, Israel
Due to genetic polymorphism about 15%-30% of the world population have low levels of MBL (Mannose Binding Lectin) in serum (below 500ng/mL).
Different studies reported correlation between polymorphism in the MBL gene with low levels of MBL in serum and higher frequency of recurrent infections, severity of sepsis, ARDS and other infections.
Urinary Tract Infection (UTI) is one of the very common infection in women.
Since MBL is part of the innate immunity and there are proofs of relation between patients with recurrent infections and lack of MBL, we decided to explore a possible relation between low levels of MBL and different genotypes of MBL in young women and the risk to develop recurrent UTI.
Study Overview
Status
Completed
Conditions
Study Type
Observational
Enrollment (Anticipated)
200
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Afula, Israel, 18101
- Ha'Emek Medical Center
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 50 years (ADULT)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
Female
Sampling Method
Non-Probability Sample
Study Population
young women with recurrent UTI - study group and young women witout recurrent UTI - a control group
Description
Inclusion Criteria:
- women above 18 years old.
- premenopausal
- recurrent UTI
Exclusion Criteria:
- pregnancy
- immunocompromised
- active malignancy
- HIV carrier
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
February 1, 2008
Study Registration Dates
First Submitted
February 17, 2008
First Submitted That Met QC Criteria
May 14, 2008
First Posted (ESTIMATE)
May 15, 2008
Study Record Updates
Last Update Posted (ESTIMATE)
April 23, 2009
Last Update Submitted That Met QC Criteria
April 22, 2009
Last Verified
April 1, 2009
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 0080-07-EMC
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Recurrent Urinary Tract Infections
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NorthShore University HealthSystemCompletedUrinary Tract Infections, RecurrentUnited States
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Nationwide Children's HospitalThrasher Research FundCompletedCatheter-Related Infections | Recurrent UTIsUnited States
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Study Group for Urogenital Diseases, ItalyUnknownRecurrent Urinary Tract InfectionsItaly
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University of ThessalyUnknownRecurrent Urinary Tract Infections in Women
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University of California, IrvineCompletedRecurrent Urinary Tract InfectionUnited States
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IRCCS Policlinico S. MatteoCompletedAntibiotic Resistance | Antibiotic Prophylaxis | Recurrent Urinary Tract InfectionsItaly
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University of Wisconsin, MadisonNational Institutes of Health (NIH)CompletedRecurrent Urinary Tract Infections in WomenUnited States
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Lawson Health Research InstituteUniversity of Western Ontario, CanadaCompletedUrinary Tract Infection | Recurrent Urinary Tract InfectionCanada
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Radboud University Medical CenterIBSA Institut Biochimique SA; Goodlife Pharma B.V.RecruitingRecurrent Urinary Tract InfectionNetherlands