Efficacy Evaluation of Observation Unit Cardiac Magnetic Resonance Imaging (MRI) in Patients With Intermediate Risk Acute Chest Pain

November 6, 2017 updated by: Wake Forest University Health Sciences
The purpose of this study is to investigate the best way to evaluate patients with chest pain in the emergency department. It compares types of cardiac tests performed while receiving treatment in an observation unit. Patients will either undergo cardiac MRI testing or conventional care testing. Patients treated in the conventional care testing group will undergo the testing their doctor determines is best for them. All patients will undergo follow up to find out if they have had any heart related events.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Despite spending $12 billion annually on the emergency evaluation of chest pain in the US, only 15% of admitted patients have a cardiac cause of their presenting symptoms. Observation units (OU) improve resource utilization, are endorsed by the ACC/AHA guidelines, but have seen limited implementation in non-low risk chest pain patients due to limitations of traditional cardiac testing. Cardiac magnetic resonance imaging (CMR) is sensitive and specific for ischemia, can simultaneously assess cardiac function and myocardial perfusion, and could revolutionize the diagnostic process for intermediate risk patients with chest pain. The superior accuracy of CMR could decrease testing resulting from false positive results. The high sensitivity for ongoing ischemia could allow imaging in parallel with cardiac markers.

Research hypotheses:

OU-CMR will have superior therapeutic efficacy to OU-conventional testing.

An OU-CMR strategy will have higher diagnostic thinking efficacy than OU-conventional testing.

Methods summary:

To address the question of feasibility of a CMR approach to managing patients at intermediate risk for ACS, we propose a randomized clinical trial of 120 patients at intermediate risk of ACS that present to the ED of Wake Forest University Baptist Medical Center (WFUBMC) for evaluation of chest pain. All patients will receive care in an OU, and will be randomized to CMR, or conventional testing. CMR participants will undergo cardiac markers and CMR testing; conventional testing participants will undergo serial cardiac markers followed by conventional cardiac testing. ACS (infarction, death, coronary revascularization, unstable angina) will be assessed by evaluation of hospital course and phone follow-up at 30 days. Cost of hospital care will be compared among groups.

Study Type

Interventional

Enrollment (Actual)

124

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • North Carolina
      • Winston-Salem, North Carolina, United States, 27157
        • Wake Forest University Baptist Medical Center - Emergency Department

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Age greater than or equal to 18 years
  • Chest discomfort or other symptoms consistent with possible ACS
  • TIMI risk score ≥ 1 or physician impression* of intermediate or high likelihood symptoms represent ACS
  • Patient requires an inpatient or observation unit evaluation for their chest pain
  • The treating physician feels the patient could be discharged home if cardiac disease was excluded
  • ED attending feels patient is safe for observation unit care**

Exclusion Criteria:

  • Initial troponin I > 1.0 ng/ml
  • New ST-segment elevation (≥1mV) or depression (≥2 mV)
  • Contra-indications to MRI (listed below)
  • Unable to lie flat
  • Hypotension (systolic < 90 mm Hg)
  • Renal insufficiency (estimated GFR < 45 cc/min) or end stage renal disease
  • Life expectancy less than 3 months
  • Patient refusal of medical record review and follow-up at 30 days
  • Pregnancy
  • Liver, heart, or kidney transplant
  • Chronic liver disease
  • Unable to speak English or Spanish
  • The ED attending feels that cardiac catheterization is indicated
  • The ED care provider intends to order a CT coronary angiogram

(*)Physicians are encouraged to use the 2007 ACC/AHA guidelines for the management of patients with NSTE ACS as a framework for this assessment.(1)

(**)These patients should generally not be considered for observation unit care: PCI / CAGB in past 6 months, multiple stents, multiple prior MIs

Contraindications to MRI: (Pacemaker, defibrillator, cerebral aneurysm clips, metallic ocular foreign body, implanted devices, claustrophobia)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Diagnostic
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: 1
Cardiac MRI Protocol. Patients will be transferred to the observation unit and undergo a stress cardiac MRI evaluation.
Other: OU - Cardiac MRI
During ED evaluation, patients are randomized to cardiac MRI or conventional care testing.
Experimental: 2
Conventional care cardiac testing. Patients will be transferred to the observation unit and undergo cardiac testing as determined by their treating physician.
Other: OU - Conventional Care Testing
Patients in the conventional testing arm will undergo testing as determined by their treating physician.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Therapeutic efficacy: Length of stay
Time Frame: Duration of Initial Hospitalization
Duration of Initial Hospitalization

Secondary Outcome Measures

Outcome Measure
Time Frame
Therapeutic efficacy: Correct cardiovascular admission decision
Time Frame: Duration of Initial Hospitalization
Duration of Initial Hospitalization
Therapeutic efficacy: Non-therapeutic cardiac catheterizations
Time Frame: 30 days
30 days
Diagnostic thinking efficacy: change in diagnostic certainty
Time Frame: 30 days
30 days
Cost of index hospitalization
Time Frame: Duration of Initial Hospitalization
Duration of Initial Hospitalization

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Wake Forest University Health Sciences

Collaborators

American Heart Association

Investigators

  • Principal Investigator: Chadwick Miller, M.D., WFUBMC

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2009

Primary Completion (Actual)

September 1, 2010

Study Completion (Actual)

October 1, 2011

Study Registration Dates

First Submitted

March 24, 2009

First Submitted That Met QC Criteria

March 24, 2009

First Posted (Estimate)

March 25, 2009

Study Record Updates

Last Update Posted (Actual)

November 8, 2017

Last Update Submitted That Met QC Criteria

November 6, 2017

Last Verified

April 1, 2017

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • IRB00008247
  • AHA Identification # 0980008N

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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