- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00875823
International Registry for Primary Hyperoxaluria
April 6, 2015 updated by: Mayo Clinic
International Registry for Hereditary Calcium Stone Diseases
The purpose of this study is to collect medical information from a large number of patients in many areas of the world with primary hyperoxaluria.
This medical information will be entered into a registry to help the investigators compare similarities and differences in patients and their symptoms.
The more patients that the investigators are able to enter into the registry, the more the investigators will be able to understand primary hyperoxaluria and learn better ways of treating patients with this disease.
It is the investigators hope that by entering as many patients with PH as possible, the information that the investigators collect may help physicians diagnose patients sooner and determine what treatments may work best on patients with similar medical or genetic backgrounds.
Study Overview
Status
Withdrawn
Conditions
Detailed Description
This study involves the collection of medical information to create a computer database (registry) for patients with PH.
The information will be entered into the registry by your physician, healthcare provider or a staff member of the Mayo Clinic Hyperoxaluria Center.
The computer web site for the registry is secure and protected by a required password.
Some information which will be entered may include your age at first symptoms of PH,kidney stone history, lab values, kidney function, and your health over time.
Information for a patient can only be viewed by the appropriate physician and staff.
Once the information is entered into the registry, you will only be identified by a code number.
Study Type
Observational
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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California
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Los Angeles, California, United States, 90095
- Mattel Children's Hospital at UCLA
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Sacramento, California, United States, 95817
- University of California at Davis
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Illinois
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Chicago, Illinois, United States, 60614
- Children's Memorial Hospital
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Minnesota
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Rochester, Minnesota, United States, 55905
- Mayo Clinic Rochester
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Any patient with a confirmed diagnosis of primary hyperoxaluria (PH)
Description
Inclusion Criteria:
- Liver biopsy or genetic analysis that confirms a diagnosis of hyperoxaluria
- In the absence of a liver biopsy:
- Urine oxalate excretion of >0.8 mmol/1.73 m² /day without other causes such as enteric hyperoxaluria
- Family history of PH in a sibling will be supportive
- A history or current finding of kidney stones or nephrocalcinosis will be supportive
- An increase in urine glycolate may suggest PHI or an increase in urine L-glycerate may suggest PHII, though not required for diagnosis.
- Patients presenting in renal failure with an elevate pre-dialysis plasma oxalate of 60 umol/l and a kidney biopsy that confirms extensive oxalate deposition, or evidence of systemic oxalosis
Exclusion Criteria:
- Patients without any of the above or a confirmed diagnosis of PH
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Retrospective
Cohorts and Interventions
Group / Cohort |
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PH Patients
Patients with: Primary Hyperoxaluria Type I Primary Hyperoxaluria Type II Primary Hyperoxaluria NonI-NonII |
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: John C Lieske, M.D., Mayo Clinic Department of Nephrology and Hypertension
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
September 1, 2003
Primary Completion (Actual)
July 1, 2009
Study Completion (Actual)
July 1, 2009
Study Registration Dates
First Submitted
April 2, 2009
First Submitted That Met QC Criteria
April 2, 2009
First Posted (Estimate)
April 3, 2009
Study Record Updates
Last Update Posted (Estimate)
April 7, 2015
Last Update Submitted That Met QC Criteria
April 6, 2015
Last Verified
April 1, 2015
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Metabolic Diseases
- Kidney Diseases
- Urologic Diseases
- Genetic Diseases, Inborn
- Pathological Conditions, Anatomical
- Carbohydrate Metabolism, Inborn Errors
- Metabolism, Inborn Errors
- Calcium Metabolism Disorders
- Urolithiasis
- Urinary Calculi
- Calculi
- Calcinosis
- Hyperoxaluria
- Kidney Calculi
- Nephrolithiasis
- Nephrocalcinosis
- Hyperoxaluria, Primary
Other Study ID Numbers
- 1605-03
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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