- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00954109
Acute Cardiovascular and Metabolic Effects of Exercise Training in Individuals With Insulin Resistance
April 3, 2015 updated by: US Department of Veterans Affairs
Physical Inactivity and Insulin Resistance in Skeletal Muscle
The overall aim of the project is to determine whether or not exercise influences cardiovascular or nervous responses to meal ingestion in individuals with insulin resistance or type 2 diabetes.
Study Overview
Detailed Description
Participants will undergo a screening procedure, including telephone screening and physical examination, as well as determination of body composition and fitness.
Participants will be asked to complete 5-10 days of supervised exercise training and will undergo testing to assess cardiovascular and metabolic responses to an oral glucose tolerance test, including muscle sympathetic nerve activity, blood flow, and circulating glucose and insulin concentrations at baseline and following training.
In addition, day-to-day variations in blood glucose will also be monitored.
The overall aim of the project is to determine whether or not acute exercise training influences postprandial metabolic, vascular or autonomic nervous system responses in individuals with insulin resistance or T2D.
Study Type
Interventional
Enrollment (Actual)
11
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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Missouri
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Columbia, Missouri, United States, 65201-5297
- Harry S. Truman Memorial VA Medical Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
30 years to 65 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Insulin resistant: diagnosed with pre-diabetes or fasting blood glucose >/= 100 mg/dL
- T2D: diagnosed by primary care physician
- BMI: less than 43 kg/m2
- Age: 30-65
Exclusion Criteria:
- Smoking
- Insulin use (other than once daily)
- Underlying conditions that limit ability to exercise safely
- Recent weight gain or loss (>5% of body weight in 3 months)
- Physically active (>30 min aerobic exercise, 2 d/wk)
- Recent (<3 mo) changes in medication use or dose
- Uncontrolled T2D (HbA1c>10%)
- Advanced retinopathy or neuropathy
- Pregnancy
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Exercise
exercise - supervised exercise (treadmill walking or cycle ergometer use)
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daily exercise: supervised treadmill walking or cycle ergometry use
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Insulin Sensitivity After 5-7 Days of Exercise
Time Frame: baseline and 24h after 5-7 days of exercise
|
Insulin sensitivity measured during an oral glucose tolerance test measured by the Matsuda Index.
Matsuda insulin sensitivity index= 10000/square root of [(fasting glucose × fasting insulin) × (mean glucose × mean insulin during oral glucose tolerance test).
|
baseline and 24h after 5-7 days of exercise
|
Blood Flow in Response to Oral Glucose Tolerance Tests
Time Frame: pre and 24 hours post 5-7 days of exercise
|
Blood flow response in the femoral artery measured by Doppler ultrasound during and oral glucose tolerance test.
Data are represented as % change in blood flow during the oral glucose tolerance at 60 minutes vs. 0 minutes (prior to drinking the glucose)
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pre and 24 hours post 5-7 days of exercise
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: John Thyfault, PhD, Harry S. Truman Memorial VA Medical Center
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Mikus CR, Fairfax ST, Libla JL, Boyle LJ, Vianna LC, Oberlin DJ, Uptergrove GM, Deo SH, Kim A, Kanaley JA, Fadel PJ, Thyfault JP. Seven days of aerobic exercise training improves conduit artery blood flow following glucose ingestion in patients with type 2 diabetes. J Appl Physiol (1985). 2011 Sep;111(3):657-64. doi: 10.1152/japplphysiol.00489.2011. Epub 2011 Jul 7.
- Mikus CR, Oberlin DJ, Libla J, Boyle LJ, Thyfault JP. Glycaemic control is improved by 7 days of aerobic exercise training in patients with type 2 diabetes. Diabetologia. 2012 May;55(5):1417-23. doi: 10.1007/s00125-012-2490-8. Epub 2012 Feb 4.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
August 1, 2009
Primary Completion (Actual)
December 1, 2010
Study Completion (Actual)
December 1, 2010
Study Registration Dates
First Submitted
August 4, 2009
First Submitted That Met QC Criteria
August 5, 2009
First Posted (Estimate)
August 7, 2009
Study Record Updates
Last Update Posted (Estimate)
April 6, 2015
Last Update Submitted That Met QC Criteria
April 3, 2015
Last Verified
April 1, 2015
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- CDA-2-051-07S
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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