- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01009307
Study of Blood and Cheek Cell Samples From Patients With Glioma
San Francisco Bay Area Adult Glioma Prognosis Study Protocol
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This research study is looking at blood and cheek cell samples from patients with glioma.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
OBJECTIVES:
Primary
- Determine factors related to glioma survival in patients from two population-based case series collected in the San Francisco Bay Area between August 1991 and April 1994 (series 1) and May 1997 and August 1999 (series 2).
Secondary
- Determine vital status for 879 patients in the two San Francisco Bay Area population-based series through July 2004.
- Determine survival as a function of established, potential, and yet unstudied prognostic indicators.
- Gather data to validate results from this study with information from adult glioma patients enrolled prospectively at the UCSF-Neuro-Oncology clinic and through series 3 of the San Francisco Bay Area Adult Glioma Study; incorporate results from this study and other components of the SPORE into ongoing clinical investigations at the Brain Tumor Research Center and Neuro-Oncology Service at UCSF.
- Using funding from the organization Accelerate Brain Cancer Cure (ABC2), genotype several thousand single nucleotide polymorphisms (SNPs) from some study participants; assess these SNPs for potential relationship to glioma survival.
OUTLINE: Medical records of patients registered to the California Cancer Registry or the Northern California Cancer Center SEER are reviewed for mortality and treatment information related to the brain tumor. Blood and buccal specimens are collected from patients with newly diagnosed disease who are being seen at the UCSF Neuro-Oncology Service. The specimens are used for polymorphism and tumor marker studies and other pertinent data. Tumor specimens and treatment information related to the brain tumor are also collected from the SPORE Tissue Core.
Additional tumor makers are studied, including: chromosome 1p/19q, 7q studies; DNA repair and oxidative metabolism polymorphisms; and up to 2 tumor markers and 2 constitutive genotyping studies.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
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California
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San Francisco, California, United States, 94115
- UCSF Helen Diller Family Comprehensive Cancer Center
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
DISEASE CHARACTERISTICS:
- Diagnosis of glioma
Meets 1 of the following criteria:
- Participant in the Survival study of San Francisco Bay Area Adult Glioma Study (SFBAAGS) Series 1 and 2
- Treated by UCSF Neuro-Oncology Service; diagnosed between Nov. 1, 2001 and June 30, 2006 and seen between Aug. 1, 2002 and June 30, 2006
- Participant in SFBAAGS Series 3 (not seen at UCSF Neuro-Oncology Service) diagnosed between Nov. 1, 2001 and Oct. 31, 2004
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Study Plan
How is the study designed?
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
Factors related to glioma survival
|
Collaborators and Investigators
Collaborators
Investigators
- Study Chair: Margaret Wrensch, University of California, San Francisco
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
- adult glioblastoma
- adult giant cell glioblastoma
- adult gliosarcoma
- recurrent adult brain tumor
- adult anaplastic astrocytoma
- adult anaplastic ependymoma
- adult anaplastic oligodendroglioma
- adult brain stem glioma
- adult diffuse astrocytoma
- adult ependymoblastoma
- adult ependymoma
- adult medulloblastoma
- adult myxopapillary ependymoma
- adult oligodendroglioma
- adult pineoblastoma
- adult pineocytoma
- adult subependymoma
- adult supratentorial primitive neuroectodermal tumor (PNET)
- adult mixed glioma
- adult pilocytic astrocytoma
- adult subependymal giant cell astrocytoma
- adult pineal gland astrocytoma
Additional Relevant MeSH Terms
Other Study ID Numbers
- CDR0000437072
- UCSF-H6539-04956-13A
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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