Functional Neuroimaging of Postural Reconstruction

Functional Neuroimaging of Postural Reconstruction: Preliminary Study on a Dorsiflexion Motion of the Ankle and Comparison Between an Arm Following Postural Reconstruction Program and a Comparator Arm Following a Muscular Stretching Program

To study in two cross-sections of healthy volunteers, with single photon emission computed tomography (SPECT), the possible changes generated in the mid-term by two rehabilitation techniques: the postural reconstruction and the muscular stretching. The changes in the cortical activation patterns will be estimated during a non-specific position of the ankle, held static.

The influence of each technique will be estimated though the evidence of a change in the functional mapping of the areas activated during the defined motor task on healthy volunteers.

Study Overview

• Status: Completed
• Conditions: Healthy
• Intervention / Treatment: Radiation: SPECT : ECD-Tc99m - Neurolite, Bristol-Myers Squibb Medical Imaging

Detailed Description

This is a monocentre, randomized study.

• Study Type: Interventional
• Enrollment (Anticipated): 16
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Strasbourg, France, 67000
    • University Hospital Strasbourg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• male or female 18 to 35 years old

Exclusion Criteria:

• pregnant, lactating

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Postural Reconstruction	Radiation: SPECT : ECD-Tc99m - Neurolite, Bristol-Myers Squibb Medical Imaging
Active Comparator: muscular stretching	Radiation: SPECT : ECD-Tc99m - Neurolite, Bristol-Myers Squibb Medical Imaging

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Change in the functional mapping of the areas activated during the defined motor task on healthy volunteers.	8 months

Collaborators and Investigators

• Sponsor: University Hospital, Strasbourg, France
• Investigators: Principal Investigator: Izzie Jacques Namer, Md, University Hospital, Strasbourg, France

Study record dates

Study Major Dates

• Study Start: November 1, 2009
• Primary Completion (Actual): April 1, 2010
• Study Completion (Actual): April 1, 2010

Study Registration Dates

• First Submitted: November 13, 2009
• First Submitted That Met QC Criteria: November 13, 2009
• First Posted (Estimate): November 16, 2009

Study Record Updates

• Last Update Posted (Estimate): April 29, 2010
• Last Update Submitted That Met QC Criteria: April 28, 2010
• Last Verified: April 1, 2010

More Information

Terms related to this study

• Keywords: healthy subjects; Volunteers
• Additional Relevant MeSH Terms: Molecular Mechanisms of Pharmacological Action; Radiopharmaceuticals; Technetium Tc 99m bicisate
• Other Study ID Numbers: 4551