- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01014780
Tear Film Thickness Measured Using a Novel Technique
The aim of this investigation is to determine the thickness of the human preocular tear film using a new method based on laser speckle. This will be a preliminary study to generate "normative" tear film thickness data in normal (i.e., non dry eye) and dry eye subjects in a clinic-based population. In addition, we will examine the short term (i.e., one week) repeatability of the method in a single setting.
The patients classified as having dry eye will also have their tear film thickness measured after instillation of an artificial tear. This will potentially reveal valuable data in retention of effect measured non-invasively as in prior studies that employed a fluorescein tracer.
Study Overview
Status
Conditions
Detailed Description
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Locations
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California
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Fullerton, California, United States, 92831'
- Southern California College of Optometry
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
There are no requirements as to subject race, gender or occupation. If the subjects have any questions or concerns regarding any of the inclusion or exclusion criteria, they will be encouraged to ask either investigator (Dr. Paugh or Dr. Kwan) for clarification. All subjects must meet the following criteria:
- The informed consent document must be read, signed and dated by the subject before conducting any procedures. Additionally, the informed consent document must be signed and dated by the individual obtaining consent of the subject. HIPAA authorization must also be signed and dated by the subject.
Adult subjects, 18 years of age and older. Criteria for the mild to severe dry eye group must include two of the three following characteristics as demonstrated at the Eligibility visit:
- Composite symptom score of ≥ 7 on the Schein questionnaire:
- Sodium fluorescein (NaFl) tear break-up time ≤ 7 seconds in either (worse) eye
- Cumulative sodium fluorescein (NaFl) corneal staining ≥ 4 in either (worse) eye on a 0-20 point scale (corresponds to ≥ 3.0 on a 0-15 scale).
- Able and willing to follow study instructions.
- Willing to return for the repeatability visit within 7 plus or minus 2 days of the initial visit, and within the same one-half day (i.e., either in the morning or afternoon, similar to the first tear thickness visit).
- Subjects must have best corrected visual acuity of 20/25 or better in each eye as assessed using a standard Snellen acuity chart.
- Subjects wearing soft contacts lenses must be willing to discontinue wear for two days before each study visit.
- Subjects using any topical drops such as artificial tears must be willing to discontinue use of such drops for two days prior to all visits, including the baseline visit.
Exclusion Criteria:
Subjects demonstrating any medical condition that may affect the results of this study SHOULD NOT be enrolled. The following are specific conditions that exclude subjects from enrollment in this study:
- History or evidence of ocular or intraocular surgery in either eye within the past six months. LASIK and other kerato-refractive procedure patients can qualify if the most recent surgery or enhancement was 12 or more months prior.
- History or evidence of serious ocular trauma in either eye within the past six months.
- History of hypersensitivity to sodium fluorescein.
- History or evidence of epithelial herpes simplex keratitis (dendritic keratitis); vaccinia, active or recent varicella, viral disease of the cornea and/or conjunctiva; chronic bacterial disease of the cornea and/or conjunctiva; mycobacterial infection of the eye; and/or fungal disease of the eye.
- Patients requiring use of topical ocular medications such as glaucoma or allergy medications during the study period.
- Individuals using systemic steroids, immunosuppressive agents and/or anti-cholinergics (e.g. cold and allergy medications, tricyclic antidepressants) for treatment of autoimmune connective tissue disease may not be enrolled in the study if they have not been on a stable dosing regimen for a minimum of 30 days prior to the first visit. In addition, the dosing regimen must remain stable throughout the study period, expected to be approximately one week.
- Individuals with diabetes.
- Ocular conditions such as conjunctival infections, or iritis.
- Individuals wearing rigid gas permeable contact lenses or using punctal plugs.
- Participation in an investigational drug or device study within 30 days of entering this study.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Normal (non-dry) dry eye subjects
These are healthy individuals, age 18 and above, who do not exhibit dry eyes by signs and symptoms
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Dry eye subjects
These are subjects, age 18 years and above, who do exhibit signs and symptoms of dry eye.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Tear film thickness in normal eyes
Time Frame: 1-3 months
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1-3 months
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Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Tear thickness change following viscous drop instillation
Time Frame: 1-3 months
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1-3 months
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Collaborators and Investigators
Investigators
- Study Director: Jerry Paugh, OD. PhD, Southern California College of Optometry at Marshall B. Ketchum University
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 09-10
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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