Preconditioning Volatile Anesthesia in Liver Surgery

November 25, 2009 updated by: University of Zurich

Preconditioning is Indeed Protective

The purpose of this study is to compare the impact and outcome of continuous volatile anesthesia to continuous intravenous anesthesia and to preconditioning volatile anesthesia in liver surgery.

Study Overview

Status

Completed

Conditions

Detailed Description

Comparing the impact and outcome of continuous volatile anesthesia to continuous intravenous anesthesia and to preconditioning volatile anesthesia in liver surgery.

Study Type

Observational

Enrollment (Actual)

257

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Switzerland
      • Zurich, Switzerland, 8091
        • Universtiy Hospital of Zurich, Department of Visceral and Transplantation Surgery

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 90 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Consecutive patients were included undergoing any type of liver resection with inflow occlusion for benign as well as malign diseases between January first, 2005 and December 31, 2007 in a single tertiary care center

Description

Inclusion Criteria:

  • > 18 years
  • benign and malign disease
  • any type of liver surgery
  • inflow occlusion during the liver surgery

Exclusion Criteria:

  • < 18 years
  • participation on other interventional and treatment randomized controlled trials,
  • trauma of the liver
  • liver cirrhosis

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
group1
continuous volatile anesthesia (sevoflurane) during the liver resection
group2
continuous intravenous anesthesia (propofol) during the liver resection
group3
preconditioning volatile anesthesia (sevoflurane) 30 minutes before ischemia (inflow occlusion)

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
peak ALT and AST levels representing the ischemia-reperfusion injury
Time Frame: post-operative
post-operative

Secondary Outcome Measures

Outcome Measure
Time Frame
length of hospital stay, length of ICU stay, blood loss and morbidity (post-operative complications)
Time Frame: post-operative
post-operative

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Zurich

Investigators

  • Principal Investigator: Ksenija Slankamenac, med. pract, Departement of Visceral and Transplantation

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2008

Primary Completion (Actual)

October 1, 2009

Study Completion (Actual)

October 1, 2009

Study Registration Dates

First Submitted

November 25, 2009

First Submitted That Met QC Criteria

November 25, 2009

First Posted (Estimate)

November 26, 2009

Study Record Updates

Last Update Posted (Estimate)

November 26, 2009

Last Update Submitted That Met QC Criteria

November 25, 2009

Last Verified

November 1, 2009

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • StV 18-2008

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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