Breathing Disorders in Patients With Congestive Heart Failure

Breathing Disorders in Patients With Congestive Heart Failure: Gender and Mortality Impact

The investigators prospectively evaluated 89 consecutive outpatients (29 female) with stable congestive heart failure. The presence of sleep disordered breathing (SDB) and Cheyne-Stokes respiration (CSR) while awake were investigated by overnight polysomnography. Males and females were similar in age, body mass index, and LVEF. Prevalence of SDB was higher in males than females. During follow up of 25±10 months, 27% of the population died. Nonsurvivors had lower LVEF (p=0.01), worse NYHA class (p=0.03) a higher proportion of CSR-awake (p<0.001) than survivors.

Study Overview

• Status: Completed
• Conditions: Congestive Heart Failure
• Intervention / Treatment: Other: Polysomnography

Detailed Description

Bakground: There is little information in sleep disordered breathing (SDB) in women with congestive heart failure (CHF). We studied consecutive CHF patients in order to compare SDB characteristics according to gender, and to determine overall mortality impact of SDB and Cheyne-Stokes respiration (CSR) while awake.

Methods: Eighty nine consecutive outpatients (29 female) with stable CHF (LVEF<45%) were prospectively evaluated. The presence of SDB, as characterized by obstructive sleep apnea (OSA) and CSR during sleep, as well as CSR while awake before sleep onset, were investigated by overnight polysomnography.

• Study Type: Observational
• Enrollment (Actual): 89

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 75 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients with CHF recruited from the outpatient Heart Failure Unit of the Heart Institute (Instituto do Coraçao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo)

Description

Inclusion Criteria:

• Patients with resting left ventricular ejection fraction (LVEF) of less than 45% as determined by echocardiography;
• Stable clinical condition as defined by no changes in drug therapy for at least one month before evaluation.

Exclusion Criteria:

• Patients with neurological, pulmonary, renal, musculoskeletal disease, unstable angina, primary valvular heart disease or previous diagnosis of sleep disordered breathing.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
CHF Patients; Congestive Heart Failure Patients	Other: Polysomnography; examination for sleep disorders

Collaborators and Investigators

• Sponsor: University of Sao Paulo
• Investigators: Principal Investigator: Rogerio S Silva, PhD, University of Sao Paulo

Study record dates

Study Major Dates

• Study Start: November 1, 2001
• Study Completion (Actual): March 1, 2004

Study Registration Dates

• First Submitted: May 15, 2007
• First Submitted That Met QC Criteria: January 12, 2010
• First Posted (Estimate): January 13, 2010

Study Record Updates

• Last Update Posted (Estimate): January 13, 2010
• Last Update Submitted That Met QC Criteria: January 12, 2010
• Last Verified: May 1, 2007

More Information

Terms related to this study

• Keywords: Congestive Heart Failure; Sleep apnea; Cheyne-Stokes Respiration
• Additional Relevant MeSH Terms: Heart Diseases; Cardiovascular Diseases; Heart Failure
• Other Study ID Numbers: 823/01