Evaluation of a New CZT System

Evaluation of a New CZT System for Imaging in Routine Nuclear Medicine Examination

The purpose of the study is to check if the new CZT system has an advantage in detection of small osseous processes, thyroid adenomas, parathyroid adenomas and detection of sentinel node, in comparison with the techniques in use.

Participants: 100 subjects male and female that come to the institute of nuclear medicine for routine screening examinations.

The CZT screening takes 10 minutes and does not require any extra intervention to the routine screening.

Study Overview

• Status: Unknown
• Conditions: Parathyroid Adenoma; Thyroid Adenoma

• Study Type: Observational
• Enrollment (Anticipated): 100

Contacts and Locations

Study Locations

• Israel
  • Tel Aviv, Israel
    • Department of Nuclear Medicine, Tel Aviv Sourasky Medical Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

consequtive patiants admitted for the above scans and consented to be further investigated by the CZT system

Description

Inclusion Criteria:

• age over 18

Exclusion Criteria:

• pregnancy
• patients unable to understand and sign an informed consent
• age under 18

Study Plan

How is the study designed?

Number of groups / cohorts

4

Cohorts and Interventions

Group / Cohort
hand; patients admitted for Tc MDP for evaluation of carpal/metacarpal and finger bone lesions
thyroid; patients admitted for Tc thyroid scan
parathyroid; patients investigated for parathyroid adenoma
sentinel node; patients who are due to sentinel node biopsy

Collaborators and Investigators

• Sponsor: Tel-Aviv Sourasky Medical Center
• Investigators: Principal Investigator: Einat Even Sapir, PhD, MD, Tel Aviv Sourasky medical Center, Tel Aviv, Israel

Publications and helpful links

General Publications

• Gambhir SS, Berman DS, Ziffer J, Nagler M, Sandler M, Patton J, Hutton B, Sharir T, Haim SB, Haim SB. A novel high-sensitivity rapid-acquisition single-photon cardiac imaging camera. J Nucl Med. 2009 Apr;50(4):635-43. doi: 10.2967/jnumed.108.060020.
• Hruska CB, Phillips SW, Whaley DH, Rhodes DJ, O'Connor MK. Molecular breast imaging: use of a dual-head dedicated gamma camera to detect small breast tumors. AJR Am J Roentgenol. 2008 Dec;191(6):1805-15. doi: 10.2214/AJR.07.3693.
• Mueller B, O'Connor MK, Blevis I, Rhodes DJ, Smith R, Collins DA, Phillips SW. Evaluation of a small cadmium zinc telluride detector for scintimammography. J Nucl Med. 2003 Apr;44(4):602-9.
• Ketchum LE. New equipment in nuclear medicine, part 1: solid-state detectors. J Nucl Med. 1998 Nov;39(11):15N, 35N-36N. No abstract available.
• Rhodes DJ, O'Connor MK, Phillips SW, Smith RL, Collins DA. Molecular breast imaging: a new technique using technetium Tc 99m scintimammography to detect small tumors of the breast. Mayo Clin Proc. 2005 Jan;80(1):24-30. doi: 10.1016/S0025-6196(11)62953-4.
• O'Connor MK, Phillips SW, Hruska CB, Rhodes DJ, Collins DA. Molecular breast imaging: advantages and limitations of a scintimammographic technique in patients with small breast tumors. Breast J. 2007 Jan-Feb;13(1):3-11. doi: 10.1111/j.1524-4741.2006.00356.x.
• Tsuchimochi M, Hayama K, Oda T, Togashi M, Sakahara H. Evaluation of the efficacy of a small CdTe gamma-camera for sentinel lymph node biopsy. J Nucl Med. 2008 Jun;49(6):956-62. doi: 10.2967/jnumed.108.050740. Epub 2008 May 15.

Study record dates

Study Major Dates

• Study Start: March 1, 2010
• Primary Completion (Anticipated): March 1, 2011

Study Registration Dates

• First Submitted: March 9, 2010
• First Submitted That Met QC Criteria: March 9, 2010
• First Posted (Estimate): March 10, 2010

Study Record Updates

• Last Update Posted (Estimate): March 10, 2010
• Last Update Submitted That Met QC Criteria: March 9, 2010
• Last Verified: March 1, 2010

More Information

Terms related to this study

• Keywords: sentinel node; CZT; osseous processes
• Additional Relevant MeSH Terms: Neoplasms by Histologic Type; Neoplasms; Neoplasms by Site; Neoplasms, Glandular and Epithelial; Endocrine System Diseases; Endocrine Gland Neoplasms; Parathyroid Diseases; Thyroid Diseases; Head and Neck Neoplasms; Adenoma; Thyroid Neoplasms; Parathyroid Neoplasms
• Other Study ID Numbers: TASMC-10-EES-0649-CTIL