Resistance Training in Patients With Chronic Obstructive Lung Disease (COPD): Whole Body Vibration Versus Conventional Resistance Training (REWORK)

December 9, 2011 updated by: University Hospital, Ghent

Pulmonary rehabilitation has been emerged as a recommended standard of care for patients with chronic lung disease based on a growing body of scientific evidence. A set of evidence-based guidelines were published in American College of Chest Physicians (ACCP) and the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR). Since then, the published literature in pulmonary rehabilitation has increased substantially, and other societies have published important statements about pulmonary rehabilitation (eg, the American Thoracic Society and the European Respiratory Society).

In patients with COPD, there is a strong scientific basis for implementing conventional resistance training (CRT) in addition to endurance training. Endurance training, such as walking, is a key component of pulmonary rehabilitation and improves in exercise tolerance and muscular endurance. However, this type of training may not reverse muscle weakness or atrophy. For that reason, strength training seems to be the optimum training modality to increase muscle mass and strength.

Recently, Whole-Body-Vibration (WBV) training has been promoted as an alternative for resistance training on multigym equipment. In WBV training, the subject stands on a platform that generates vertical sinusoidal vibration, during which static and dynamic exercises can be performed.

The present study is conducted to provide an answer on the following question: will a resistance training program, such as the whole body vibration, be even effective than a conventional resistance training program in patients with COPD.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

62

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Belgium
      • Ghent, Belgium
        • University Hospital Ghent

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

40 years to 80 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Patients with COPD candidate for pulmonary rehabilitation
  • Men and female between 40 and 80 years of age
  • Written informed consent to participate

Exclusion Criteria:

  • Severe cardiac, neurological and orthopedic co-morbidity interfering with exercise training.
  • Pacemaker
  • Hip, knee of shoulder prosthesis or recently introduced spirals, metal pens, bolts or plates
  • Uncontrolled diabetes, epilepsy or migraine
  • Osteoporotic or metastatic fractures, acute hernia, discopathy, spondylitis

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Whole body vibration training
Behavioral: Whole body vibration resistance training program
WBV training on FITVIBE
Active Comparator: Conventional training
Behavioral: Conventional resistance training program
Conventional resistance training program is followed.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
estimation of the change of 6 MWD before and after 12 weeks resistance training program (CRT versus WBV training)
Time Frame: before and after 12 weeks
estimation of the change of 6 MWD (submaximal walking test)after a 12 week conventional resistance training program or after a 12 week whole body vibration training program
before and after 12 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
changes in muscle strength (quadriceps force)after CRT or after WBV training in patients with COPD
Time Frame: before and after 12 weeks
measured by modified Microfet before and after 12 weeks of training.
before and after 12 weeks
changes in body composition after CRT or after WBV training in patients with COPD
Time Frame: before and after 12 weeks
measured by bioelectrical impedance analysis: Fat Free Mass (FFM)before and after 12 weeks of training.
before and after 12 weeks
changes in maximal exercise capacity after CRT or after WBV training in patients with COPD
Time Frame: before and after 12 weeks
measured by cyclo-ergospirometry before and after 12 weeks of training
before and after 12 weeks
changes in muscle force after CRT or after WBV training in patients with COPD
Time Frame: before and after 12 weeks
measured by handgrip force, maximal inspiratory pressure (PImax) and maximal expiratory pressure (PEmax)before and after 12 weeks of training
before and after 12 weeks
changes in Quality of life after CRT or after WBV training in patients with COPD
Time Frame: beforer and after 12 weeks
measured by CRDQ (Chronic Respiratory Disease Questionnaire)before and after 12 weeks of training
beforer and after 12 weeks
changes in Dyspnea scores after CRT or after WBV training in patients with COPD
Time Frame: before and after 12 weeks
measured by Chronic Respiratory Disease Questionnaire domain dyspnea (CRDQd) and by the BORG scale before and after 12 weeks of training.
before and after 12 weeks
changes in 6MWD and the endurance test on the bicycle after CRT or after WBV training in patients with COPD
Time Frame: before and after 12 weeks
measured by endurance test on the bicycle (75% Max. Workload)before and after 12 weeks of training. This test will also be repeated after 6 weeks of training.
before and after 12 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Ghent

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

April 1, 2010

Primary Completion (Actual)

July 1, 2011

Study Completion (Actual)

November 1, 2011

Study Registration Dates

First Submitted

June 2, 2010

First Submitted That Met QC Criteria

June 2, 2010

First Posted (Estimate)

June 3, 2010

Study Record Updates

Last Update Posted (Estimate)

December 12, 2011

Last Update Submitted That Met QC Criteria

December 9, 2011

Last Verified

December 1, 2011

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2010/157

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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