Ability of Modulated Imaging and Laser Speckle Imaging to Determine Burn Wound Severity and Healing Potential

According to the National Burn Repository 2007, the most common type of burn injury is a partial thickness burns. The current standard of care for partial thickness burns is two weeks of topical therapy and wound care. Burns that do not heal within two weeks undergo surgical excision and skin grafting.

Study Overview

• Status: Recruiting
• Conditions: Skin Burn Multiple
• Intervention / Treatment: Device: Modulated Imaging and Laser Speckle Imaging

Detailed Description

Researcher can use the combination of Modulated Imaging and Laser Speckle Imaging can be used as an adjuvant to standard clinical evaluation to gauge burn wound and severity of infection. Researcher can image the burn wounds of and compare with current standard of care, clinical exam, and can use the outcomes information in terms of time to healing and treatment

Modulating Imaging is a noninvasive optical modality measure the metabolic functions of the burn wound.

Laser Speckle Imaging is a noninvasive optical modality can measure blood flow of burn wound.

• Study Type: Observational
• Enrollment (Estimated): 200

Contacts and Locations

• Study Contact: Name: Gordon Kennedy, PhD; Phone Number: 949-824-4713; Email: gordon.kennedy@uci.edu

Study Locations

• United States
  • California
    • Orange, California, United States, 92868
      • Recruiting
      • UCIMC
      • Contact: Victor Joe, MD; Phone Number: 714-456-5840

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 1 minute and older (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Study population will be selected from University of California Irvine Medical Center Burn Unit.

Description

Inclusion Criteria:

1. Male / female all age
2. Subjects is an inpatient or out patient with burn wound

Exclusion Criteria:

1. Subjects cannot lied flat and still for the duration of the imaging
2. Subjects pregnant.

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Only
• Time Perspectives: Prospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Burn wound; Modulated Imaging and Laser Speckle Imaging	Device: Modulated Imaging and Laser Speckle Imaging; wound healing; Other Names: MI-LSI developed at UCI Beckman Laser Institute

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Noninvasive burn wound severity assessment	Noninvasive burn wound severity assessment using noncontact optical device	1 day

Collaborators and Investigators

• Sponsor: University of California, Irvine
• Collaborators: National Institute of General Medical Sciences (NIGMS)
• Investigators: Principal Investigator: Anthony Durkin, PhD, University of California, Irvine

Study record dates

Study Major Dates

• Study Start: March 1, 2010
• Primary Completion (Estimated): February 1, 2028
• Study Completion (Estimated): February 1, 2030

Study Registration Dates

• First Submitted: July 20, 2010
• First Submitted That Met QC Criteria: July 20, 2010
• First Posted (Estimated): July 21, 2010

Study Record Updates

• Last Update Posted (Estimated): December 10, 2025
• Last Update Submitted That Met QC Criteria: December 3, 2025
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Keywords: burn wound
• Additional Relevant MeSH Terms: Wounds and Injuries; Burns; Investigative Techniques; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Imaging; Optical Imaging; Laser Speckle Contrast Imaging
• Other Study ID Numbers: 20097322; R01GM108634 (U.S. NIH Grant/Contract)

Drug and device information, study documents

• product manufactured in and exported from the U.S.: No