- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01208285
Study of VX-770 in Subjects With Moderate Hepatic Impairment and in Matched Healthy Subjects
January 11, 2011 updated by: Vertex Pharmaceuticals Incorporated
A Phase 1 Non-Randomized, Open-Label Study to Assess the Safety and Pharmacokinetics of VX-770 in Subjects With Moderate Hepatic Impairment and in Matched Healthy Subjects
The purpose of this study is to investigate the pharmacokinetics and safety of a single dose of VX-770 in subjects with moderate hepatic impairment.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
24
Phase
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Hradec Králové, Czech Republic
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Praha, Czech Republic
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Bratislava, Slovakia
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 65 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
Group A (Subjects with Hepatic Impairment):
- male or female between 18 and 65 years of age
- subjects must have a Child-Pugh total score of 7 to 9
- subjects must agree to use 1 highly effective method of contraception during the study and for 90 days after the completion of the study
- subjects must have a body mass index (BMI) of 18 to 35 kg/m2
Group B (Healthy Subjects):
- male or female between 18 and 65 years of age
- subjects will match subjects with hepatic impairment for sex, BMI, cigarette smoking habit, and age
- subjects must agree to use 1 highly effective method of contraception during the study and for 90 days after the completion of the study
Exclusion Criteria:
Group A (Subjects with Hepatic Impairment):
- subjects who are not clinically stable or who have a history of any illness that, in the opinion of the investigator or the subject's general practitioner, might confound the results of the study or pose an additional risk in administering study drug(s) to the subject
- subjects who are unwilling or unable to discontinue use of any inhibitors or inducers of CYP3A
- subjects who have a history of alcohol abuse within 1 year or illicit drug abuse within 2 years
- subjects who smoke more than 10 cigarettes per day
- subjects who have fluctuating or rapidly deteriorating hepatic function
- subjects who have significant renal dysfunction
- subjects who have HIV, or active hepatitis B
- subjects who have previous solid organ or bone marrow transplantation
Group B (Healthy Subjects):
- subjects who have a history of any illness that, in the opinion of the investigator or the subject's general practitioner, might confound the results of the study or pose an additional risk in administering study drug(s) to the subject
- subjects who are unwilling or unable to discontinue use of any inhibitors or inducers of CYP3A
- subjects who have a history of alcohol or illicit drug abuse within 2 years
- subjects who smoke more than 10 cigarettes per day
- subjects who have HIV, hepatitis C, or active hepatitis B
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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Experimental: Group A
approximately 12 male and female subjects with moderate hepatic impairment
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150 mg oral tablet
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Experimental: Group B
approximately 12 healthy male and female subjects
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150 mg oral tablet
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
VX-770 pharmacokinetic parameters
Time Frame: 4 or 10 Days
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4 or 10 Days
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Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
VX-770 metabolites pharmacokinetic parameters
Time Frame: 4 or 10 days
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4 or 10 days
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Safety as measured by adverse events, clinical laboratory values, standard electrocardiograms (ECGs), and vital signs
Time Frame: up to 40 days
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up to 40 days
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
September 1, 2010
Primary Completion (Actual)
December 1, 2010
Study Completion (Actual)
December 1, 2010
Study Registration Dates
First Submitted
September 22, 2010
First Submitted That Met QC Criteria
September 22, 2010
First Posted (Estimate)
September 23, 2010
Study Record Updates
Last Update Posted (Estimate)
January 12, 2011
Last Update Submitted That Met QC Criteria
January 11, 2011
Last Verified
January 1, 2011
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- VX10-770-013
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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