Astaxanthin Supplementation in Cyclists

Background of the study:

Astaxanthin has been shown to be a powerfull anti-oxidant. Health benefits have been shown in animals and humans. Exercise enhancing effects have been shown in animals via enhancement of fat oxidation. We want to examine the effects of 4 weeks of astaxanthin supplementation on fat oxidation and cycling performance in trained cyclists

Objective of the study:

To test the hypothesis that 4 weeks supplementation with astaxanthin will improve fat oxidation and improve exercise performance in trained cyclists

Study design:

Double blind, placebo controlled study.

Study population:

Well trained cyclists between 18-30 years old

Intervention (if applicable):

astaxanthin (20 mg/day) or placebo for 4 weeks

Primary study parameters/outcome of the study:

performance on a time trial after 90 min steady state exercise.

Secundary study parameters/outcome of the study (if applicable):

substrate use plasma glucose plasma lactate plasma free fatty acid plasma astaxanthin

Nature and extent of the burden and risks associated with participation, benefit and group relatedness (if applicable):

The risks involved in participating in this experiment are minimal. Astaxanthin has been shown to be safe. Insertion of the catheters in a vein is comparable to a normal blood draw and the only risk is of a small local haematoma.

Study Overview

• Status: Unknown
• Conditions: Athletic Performance
• Intervention / Treatment: Dietary supplement: placebo; Dietary supplement: astaxanthin

• Study Type: Interventional
• Enrollment (Anticipated): 24
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Netherlands
  • LI
    • Maastricht, LI, Netherlands, 6229
      • Recruiting
      • Maastricht University
      • Contact: Peter Res, MSc; Phone Number: +3143381383; Email: peter.res@maastrichtuniversity.nl

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 30 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Healthy
• Male
• Age between 18 and 30 years
• Endurance trained (≥3 sessions of endurance exercise per week)
• VO2 max ≥ 50 ml/kg/min
• Training history of more than one year of ≥3 sessions of endurance exercise per week
• BMI <25 kg/m2

Exclusion Criteria:

• Use of medication
• Smoking

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: placebo	Dietary supplement: placebo; placebo
Experimental: astaxanthin	Dietary supplement: astaxanthin; astaxanthin

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
time trial performance	time trial performance	4 weeks

Secondary Outcome Measures

Outcome Measure	Time Frame
substrate use	4 weeks

Collaborators and Investigators

• Sponsor: Maastricht University Medical Center

Publications and helpful links

General Publications

• Klinkenberg LJ, Res PT, Haenen GR, Bast A, van Loon LJ, van Dieijen-Visser MP, Meex SJ. Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: a randomized trial. PLoS One. 2013 Nov 19;8(11):e79280. doi: 10.1371/journal.pone.0079280. eCollection 2013.

Study record dates

Study Major Dates

• Study Start: November 1, 2010
• Primary Completion (Anticipated): June 1, 2011

Study Registration Dates

• First Submitted: November 15, 2010
• First Submitted That Met QC Criteria: November 15, 2010
• First Posted (Estimate): November 16, 2010

Study Record Updates

• Last Update Posted (Estimate): April 20, 2011
• Last Update Submitted That Met QC Criteria: April 19, 2011
• Last Verified: April 1, 2011

More Information

Terms related to this study

• Other Study ID Numbers: MEC 10-3-068