Sideritis Supplementation and Performance

The Effect of Sideritis as Supplement on Performance

The purpose of this study is to examine the effect of sideritis consumption on physiological and performance indicators in adult subjects and compare it with the control trial.

Study Overview

• Status: Not yet recruiting
• Conditions: Athletic Performance
• Intervention / Treatment: Dietary supplement: 950 mg of Sideritis Scardica (SidTea+) extract one hour pre-exercise; Dietary supplement: 950 mg of placebo one hour pre-exercise

Detailed Description

Significance of the Study:

There is currently no evidence supporting an improvement in athletic performance following the use of sideritis. Despite existing studies showing that the mechanism through which sideritis acts is almost identical to that of other supplements that have been found to enhance athletic performance, direct evidence for its effectiveness remains lacking.

Methodology:

Initially, the participants of the study will visit the laboratory in order to be informed about the exercise research protocol. During the first visit, the participants will perform a maximal oxygen uptake (VO₂max) test on a treadmill using the RAMP protocol. In this specific method for determining maximal oxygen uptake, the treadmill speed will increase by 1 km/h every minute. Thus, the participants will reach exhaustion gradually.

The participants will visit the laboratory two more times in order to perform the exercise protocols. One hour before each session, each participant will receive a dietary supplement, which will contain either 950 mg of sideritis or a specific dosage of a neutral substance (placebo). The selection of supplements will be random, as the study will be conducted using a double-blind design. This means that neither the participants nor the researcher will know which type of supplement has been consumed prior to the exercise protocol. The exercise protocol will consist of 60 minutes of treadmill running at an intensity of 70-75% of VO₂max, which has been individually determined for each participant based on the prior VO₂max test. During these 60 minutes, a gas exchange mask will be used to determine that participants are running at the specified intensity. After the 60 minutes, participants will wear the mask again and will run at a higher intensity (90-95% VO₂max) until exhaustion (Time to Exhaustion). Before each exercise protocol, and at 15, 30, 45, and 60 minutes during exercise, as well as immediately after completion, capillary blood samples will be collected to assess lactate and glucose levels. Additionally, body composition measurements will be conducted using the BIA method. Participants' dietary intake will also be recorded for the day prior to the VO₂max test, as well as for the days preceding the exercise protocol sessions. This recording will be conducted in order to determine whether any participant has consumed sideritis through their diet prior to the protocol.

Statistical Analysis

A 2-way repeated measures ANOVA will be performed. The statistical program SPSS 26 will be used.

• Study Type: Interventional
• Enrollment (Estimated): 12
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Athanasios Jamurtas Z Jamurtas, Professor; Phone Number: Ext. +30 24310 47054; Email: ajamurt@uth.gr

Study Locations

• Greece
  • Thessaly
    • Trikala, Thessaly, Greece, 42150
      • Exercise Biochemistry, Physiology and Nutrition Laboratory, Department of Physical Education and Sport Science, University of Thessaly

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Healthy Individuals aged 18-40 years

Exclusion Criteria:

• Musculoskeletal Injury
• Dietary supplements
• Medication

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Quadruple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Sideritis Scardica (SidTea+) extract; Sideritis Scardica (SidTea+) extract will be administered to participants in this arm.	Dietary supplement: 950 mg of Sideritis Scardica (SidTea+) extract one hour pre-exercise; 950 mg of Sideritis Scardica (SidTea+) extract one hour pre-exercise during exercise day
Placebo Comparator: Placebo Supplementation; Placebo will be administered to participants in this arm.	Dietary supplement: 950 mg of placebo one hour pre-exercise; 950 mg of placebo one hour pre-exercise during exercise day

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Blood lactate	Blood lactate concentration will be estimated using an analyzer.	Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise
Change in mean respiratory quotient during exercise	The mean respiratory quotient during exercise will be measured using a gas analyzer	Mean respiratory quotient will be measured during 60 minute of exercise
Change in mean oxygen consumption during exercise	Mean oxygen consumption during exercise will be measured using a gas analyzer	Mean oxygen consumption will be measured during 60 minute of exercise
Change in mean Heart rate during exercise	Mean heart rate during exercise will be measured using a heart rate monitor	Mean heart rate will be measured during 60 minute of exercise
Change in time to exhaustion	Time to exhaustion will be estimated using an electronic timer	The time to exhaustion will be measured immediately after 60 minute of exercise
Change in Glucose concentration	Glucose concentration will be estimated using an analyzer.	Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise
Change in heart rate	Heart rate will be estimated using monitor units.	Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise
Change in oxygen consumption	Oxygen consumption will be estimated using gas analyzer	Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise
Change in respiratory quotient	Respiratory quotient will be estimated using gas analyzer	Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Body weight	Body weight will be estimated using beam balance scale	Baseline
Body fat (%)	Body fat will be measured by bioelectrical impedance analysis	Baseline
Resting Heart Rate	Resting heart rate will be measured using a heart rate sensor	Baseline
Diastolic and systolic blood pressure	Diastolic and systolic blood pressure will be measured using a manual sphygmomanometer	Baseline
Maximal oxygen consumption (VO2max)	VO2max will be measured using an automated open-circuit spirometer	Baseline

Collaborators and Investigators

• Sponsor: University of Thessaly
• Investigators: Study Director: Athanasios Z Jamurtas, Professor, University of Thessaly

Publications and helpful links

General Publications

• Papanikolaou K, Kouloridas K, Rosvoglou A, Gatsas A, Georgakouli K, Deli CK, Draganidis D, Argyropoulou A, Michailidis D, Fatouros IG, Jamurtas AZ. Characterization of the Sideritis scardica Extract SidTea+TM and Its Effect on Physiological Profile, Metabolic Health and Redox Biomarkers in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Molecules. 2024 Mar 1;29(5):1113. doi: 10.3390/molecules29051113.

Study record dates

Study Major Dates

• Study Start (Estimated): April 25, 2026
• Primary Completion (Estimated): May 25, 2026
• Study Completion (Estimated): May 30, 2026

Study Registration Dates

• First Submitted: April 21, 2026
• First Submitted That Met QC Criteria: April 21, 2026
• First Posted (Actual): April 29, 2026

Study Record Updates

• Last Update Posted (Actual): April 29, 2026
• Last Update Submitted That Met QC Criteria: April 21, 2026
• Last Verified: April 1, 2026

More Information

Terms related to this study

• Keywords: Performance; Blood lactate; Extract; sideritis; Blood Glusose
• Other Study ID Numbers: UTH_DPESS_SID_PER

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No