Pazopanib Hydrochloride, Paclitaxel, and Carboplatin in Treating Patients With Refractory or Resistant Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Peritoneal Cancer

Phase IB-II, Open Label, Multicenter Feasibility Study of Pazopanib in Combination With Paclitaxel and Carboplatin in Patients With Platinum-Refractory/Resistant Ovarian, Fallopian Tube or Peritoneal Carcinoma

RATIONALE: Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth or by blocking blood flow to the tumor. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.

PURPOSE: This randomized phase I/II trial is studying the side effects and best dose of pazopanib hydrochloride when given together with paclitaxel and carboplatin in treating patients with refractory or resistant ovarian epithelial cancer, fallopian tube cancer, or peritoneal cancer.

Study Overview

• Status: Completed
• Conditions: Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cavity Cancer
• Intervention / Treatment: Drug: carboplatin; Other: pharmacological study; Other: laboratory biomarker analysis; Drug: paclitaxel; Drug: pazopanib hydrochloride

Detailed Description

OBJECTIVES:

Primary

• To determine the maximum-tolerated dose of pazopanib hydrochloride in combination with paclitaxel and carboplatin in patients with platinum-refractory or -resistant ovarian epithelial, fallopian tube, or peritoneal carcinoma. (Phase I)
• To determine the progression-free survival (PFS) at 1 year according to the RECIST 1.1 in these patients. (Phase II)

Secondary

• To determine the safety and adverse event profiles in these patients. (Phase I and phase II)
• To determine the pharmacokinetics (PK) of this regimen using intensive sampling. (Phase I)
• To determine if there is PK interaction (and if so, what kind of PK interaction) between carboplatin and paclitaxel as well as pazopanib hydrochloride. (Phase I)
• To determine the response rate (RR) in these patients. (Phase I)
• To determine and evaluate predictive biomarkers. (Phase I and phase II)
• To determine the RR, overall survival (OS), and PFS of these patients. (Phase II)

OUTLINE: This is a multicenter, phase I, dose-escalation study of carboplatin, paclitaxel, and pazopanib hydrochloride followed by a phase II randomized study.

• Phase I: Patients receive paclitaxel IV over 1 hour followed by carboplatin IV over 30 minutes on day 1. Patients also receive oral pazopanib hydrochloride* once daily on days 2-7. Treatment repeats every week for up to 18 courses**. Patients then continue to receive oral pazopanib hydrochloride once daily in the absence of disease progression or unacceptable toxicity.

NOTE: *Pazopanib hydrochloride is started in course 2 in order to evaluate the pharmacokinetic of paclitaxel and carboplatin prior to pazopanib hydrochloride administration.

• Phase II: Patients are stratified according to center, disease status (platinum-refractory vs -resistant) and number of prior lines of treatment (1 vs more than 1). Patients are randomized in a 2:1 ratio (arm II [experimental arm]: arm I [standard arm]) to 1 of 2 treatment arms.

  • Arm I (standard arm): Patients receive paclitaxel IV over 1 hour and carboplatin IV over 30 minutes on day 1. Treatment repeats every week for up to 18 courses.
  • Arm II (experimental arm): Patients receive paclitaxel IV over 1 hour and carboplatin IV over 30 minutes on day 1. Patients also receive oral pazopanib hydrochloride once daily on days 2-7. Treatment repeats every week for up to 18 courses**. Patients then continue to receive oral pazopanib hydrochloride once daily in the absence of disease progression or unacceptable toxicity.

NOTE: **After course 9, chemotherapy will be interrupted for 1 week.

Blood samples are collected from some patients periodically for pharmacokinetic and biomarker studies.

After completion of study treatment, patients are followed up at 3 weeks, every 3 months for 2 years, and then every 6 months for 3 years.

• Study Type: Interventional
• Enrollment (Estimated): 88
• Phase: Phase 2; Phase 1

Contacts and Locations

Study Locations

• Belgium
  • Brussels, Belgium
    • Hôpitaux Universitaires Bordet-Erasme - Institut Jules Bordet
  • Leuven, Belgium
    • U.Z. Gasthuisberg
  • Liege, Belgium
    • C.H.U. Sart-Tilman
  • Liege, Belgium
    • Centre Hospitalier Régional de la Citadelle
  • Merksem, Belgium
    • ZNA Jan Palfijn
• Netherlands
  • Nijmegen, Netherlands
    • Radboud University Medical Center Nijmegen
  • Rotterdam, Netherlands
    • Erasmus MC
• Spain
  • Badalona, Spain
    • Institut Catala d'Oncologia - ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia)
  • Madrid, Spain
    • Hospital Clínico Universitario San Carlos

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

DISEASE CHARACTERISTICS:

• Histologically confirmed ovarian epithelial, fallopian tube, or peritoneal carcinoma

  • Recurrent disease

• Received at least 1 prior platinum treatment and developed platinum-refractory disease (i.e., progression within 4 weeks of platinum administration) or platinum-resistant disease (i.e., progression within 6 months after the last platinum dose)

  • There is no restriction on the number of prior lines of treatment
  • Non-platinum treatment is allowed after proven platinum-resistance or -refractory disease
• Evaluable (measurable or nonmeasurable) disease according to RECIST version 1.1 criteria
• Patients with refractory disease on weekly paclitaxel and carboplatin regimen are excluded (phase II only)
• No known gastrointestinal intraluminal metastatic lesions with risk of bleeding
• No known endobronchial lesions and/or lesions infiltrating major pulmonary vessels
• No known brain metastases or leptomeningeal disease

PATIENT CHARACTERISTICS:

• WHO performance status 0-2
• Absolute neutrophil count ≥ 1.5 x 10^9/L
• Hemoglobin ≥ 9 g/dL
• Platelet count ≥ 100 x 10^9/L
• PT, aPTT, or INR ≤ 1.2 times upper limit of normal (ULN)
• Total bilirubin ≤ 1.5 times ULN*
• ALT and AST ≤ 2.5 times ULN*
• Serum creatinine ≤ 1.5 mg/dL OR calculated creatinine clearance ≥ 50 mL/min
• Urine protein creatinine ratio < 1 OR 24-hour urine protein < 1 g
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during study therapy
• No other prior primary or recurrent malignancies treated within the past 2 years except for completely resected non-melanomatous skin carcinoma or successfully treated carcinoma in situ of the skin or uterine cervix
• No known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs similar or related to paclitaxel, carboplatin, and pazopanib hydrochloride
• Able to receive infusions of paclitaxel and carboplatin
• Able to swallow pazopanib hydrochloride tablets
• No unstable or serious condition (e.g., uncontrolled infection requiring systemic therapy)

• No history of any of the following cardiovascular conditions within the past 6 months:

  • Myocardial infarction
  • Unstable angina
  • Symptomatic peripheral vascular disease
  • NYHA class III-IV congestive heart failure
• LVEF > 50% as assessed by ultrasound or MUGA scan, if clinically indicated

• No inadequately controlled hypertension (SBP ≥ 140 mm Hg or DBP ≥ 90 mm Hg)

  • Initiation or adjustment of blood pressure medication is permitted prior to the study entry
• No prolonged corrected QT interval (QTc) defined as > 480 msecs using Bazett formula

• No history of cerebrovascular accident within the past 6 months, including any of the following:

  • Transient ischemic attack
  • Pulmonary embolism

  • Untreated deep venous thrombosis (DVT)

    • Patients with recent DVT who have been treated with therapeutic anti-coagulating agents for at least 6 weeks are eligible
• No evidence of active bleeding or bleeding diathesis

• No clinically significant gastrointestinal (GI) tract abnormalities that may increase the risk for GI bleeding including, but not limited to, any of the following:

  • Active peptic ulcer disease
  • Inflammatory bowel disease (e.g., ulcerative colitis or Crohn disease)
• No history of bowel obstruction (excluding postoperative (i.e. within 4 weeks post surgery)) during the whole prior history of the patient, or other GI condition with increased risk of perforation such as clear infiltration into the rectosigmoid, colon or small bowel.

• No clinically significant GI abnormalities that may affect absorption of investigational product including, but not limited to, any of the following:

  • Malabsorption syndrome
  • Major resection of stomach or small bowel
• No hemoptysis in excess of 2.5 mL (one-half teaspoon) within 8 weeks prior to first dose of study drug
• No psychological, familial, sociological, or geographical condition potentially hampering compliance with the study protocol and follow-up schedule
• No trauma within the past 28 days
• No prior non-healing wounds, fracture, or ulcer

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics
• No ongoing toxicity from prior anticancer therapy > grade 1 and/or that is progressing in severity, except for alopecia and ≤ grade 2 peripheral neuropathy
• No cardiac angioplasty or stenting within the past 6 months
• No coronary artery bypass graft surgery within the past 6 months
• At least 14 days since prior radiotherapy, surgery, or tumor embolization , chemotherapy, immunotherapy, biologic therapy, investigational therapy, or hormonal therapy (28 days for drugs with a longer half-life)
• At least 14 days since prior (28 days for drugs with a longer half-life) and no concurrent prohibited medications
• At least 28 days since prior major surgery (procedures such as catheter placement and diagnostic endoscopic procedures are not considered to be major)

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: pazopanib in combination with paclitaxel and carboplatin; Phase I: Dose-escalation study of pazopanib in combination with paclitaxel and carboplatin given weekly in a group of patients with platinum-refractory or -resistant ovarian, fallopian tube or peritoneal carcinoma Phase II: Paclitaxel 30 mg/m² and Carboplatin 2.0 AUC weekly for 18 courses PLUS Pazopanib 400 mg daily	Drug: carboplatin; Other: pharmacological study; Other: laboratory biomarker analysis; Drug: paclitaxel; Drug: pazopanib hydrochloride
Active Comparator: Paclitaxel and carboplatin only; Carboplatin AUC 2.7 and paclitaxel 60mg/m² weekly for 18 courses.	Drug: carboplatin; Drug: paclitaxel; Drug: pazopanib hydrochloride

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Maximum-tolerated dose of pazopanib hydrochloride, carboplatin, and paclitaxel (phase I)
Progression-free survival according to RECIST 1.1 at 1 year (phase II)

Secondary Outcome Measures

Outcome Measure
Pharmacokinetics of pazopanib, carboplatin, and paclitaxel (phase I)
Safety and tolerability according to CTCAE 4.0 (phase I and phase II)
Response rate (phase I and phase II)
Predictive biomarkers (phase I and phase II)
Overall survival (phase II)
Age-related subanalysis for toxicity and efficacy (cut-off 65 years old) (phase II)

Collaborators and Investigators

• Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Study record dates

Study Major Dates

• Study Start: July 1, 2012
• Primary Completion (Actual): May 15, 2019
• Study Completion (Actual): July 13, 2020

Study Registration Dates

• First Submitted: July 23, 2011
• First Submitted That Met QC Criteria: July 23, 2011
• First Posted (Estimated): July 26, 2011

Study Record Updates

• Last Update Posted (Estimated): December 11, 2023
• Last Update Submitted That Met QC Criteria: December 8, 2023
• Last Verified: December 1, 2023

More Information

Terms related to this study

• Keywords: recurrent ovarian epithelial cancer; recurrent fallopian tube cancer; recurrent primary peritoneal cavity cancer
• Additional Relevant MeSH Terms: Neoplasms; Urogenital Neoplasms; Neoplasms by Site; Genital Neoplasms, Female; Adnexal Diseases; Fallopian Tube Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Genital Diseases, Female; Fallopian Tube Neoplasms; Molecular Mechanisms of Pharmacological Action; Antineoplastic Agents; Tubulin Modulators; Antimitotic Agents; Mitosis Modulators; Antineoplastic Agents, Phytogenic; Carboplatin; Paclitaxel
• Other Study ID Numbers: EORTC-55092; EU-21119; 2010-024077-39 (EudraCT Number)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No