Daily Activities Are Sufficient to Induce Dynamic Pulmonary Hyperinflation and Dyspnea in Chronic Obstructive Pulmonary Disease Patients (Hyperinflation)

Introduction: Chronic obstructive pulmonary disease is a condition characterized by airflow limitation usually progressive and associated with inflammatory response of lung noxious particles. During a physical activity chronic obstructive pulmonary disease patients may develop dynamic pulmonary hyperinflation, increased dyspnea perception and decreased activity performance. The investigators hypothesize that some specific activities of daily living induce dynamic pulmonary hyperinflation in COPD patients. Objective: To measure dynamic lung hyperinflation and its influence in dyspnea perception in moderate and severe chronic obstructive pulmonary disease patients after activities of daily living. Methods: The investigators measured inspiratory capacity, dyspnea sensation, peripheral oxygen saturation, heart rate and respiratory rate in 19 chronic obstructive pulmonary disease (COPD) patients. These measurements were taken at rest and after daily living activities (such as going up and down a set of stairs, going up and down a ramp and sweeping and mopping a room).

Study Overview

• Status: Completed
• Conditions: COPD Patients; Dynamic Lung Hyperinflation; Activities of Daily Livin.
• Intervention / Treatment: Other: Hyperinflation and ADL

• Study Type: Observational
• Enrollment (Actual): 19

Contacts and Locations

Study Locations

• Brazil
  • São Paulo/SP
    • São Paulo, São Paulo/SP, Brazil, 05414000
      • Federal University of São Paulo

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years to 80 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

The investigators included 19 COPD patients (13 male) with moderate to very severe degree of airway obstruction, with a mean post bronchodilator forced expiratory volume in the first second (FEV1) of 48.7 ± 7.1% predicted and mean age of 64.1 ± 5.3.

Description

Inclusion Criteria:

• COPD patients diagnosed with moderate to very severe airway obstruction according to GOLD classification (9)
• clinical stability with no clinical exacerbation during the previous 30 days prior to the beginning of the study and to sign an informed consent form

Exclusion Criteria:

• Inability to perform the slow vital capacity maneuver
• excessive perceived dyspnea during the test
• arterial oxyhemoglobin saturation (SpO2) lower than 80% during activities and/or need of oxygen supplementation

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
COPD hyperinflation	Other: Hyperinflation and ADL; Assessment of dynamic pulmonary hyperinflation during activities of daily living in COPD patients.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Inspiratory capacity variability within the accomplishment of activities of daily living in COPD patients.	3 months

Collaborators and Investigators

• Sponsor: Federal University of São Paulo

Study record dates

Study Major Dates

• Study Start: March 1, 2007

Study Registration Dates

• First Submitted: November 17, 2011
• First Submitted That Met QC Criteria: November 18, 2011
• First Posted (ESTIMATE): November 21, 2011

Study Record Updates

• Last Update Posted (ESTIMATE): November 21, 2011
• Last Update Submitted That Met QC Criteria: November 18, 2011
• Last Verified: November 1, 2011

More Information

Terms related to this study

• Keywords: exercise; COPD; activities of daily living; pulmonary hyperinflation
• Other Study ID Numbers: 0353/03