- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01558076
Longitudinal Changes in Exercise Capacity in Children and Young Adults With Sickle Cell Anemia
September 21, 2015 updated by: Ann & Robert H Lurie Children's Hospital of Chicago
The purpose of this study is to use comprehensive exercise testing to examine longitudinal changes in exercise capacity over a 2 year period in children and young adults with sickle cell anemia.
Study Overview
Status
Unknown
Conditions
Detailed Description
Although the burden of sickle cell anemia (SCA) on affected individuals is significant, few studies have examined the influence of having SCA on such measures of physical function as exercise capacity.
Moreover, the physiologic basis of poor physical functioning in children with SCA is unknown and has not been studied extensively.
The purpose of this proposal is to use cardiopulmonary exercise testing (CPET) to gain a comprehensive understanding of longitudinal changes in exercise capacity, and the effect of poor exercise capacity on quality of life in children and young adults with SCA.
The specific aims of this project are to: 1) Measure peak oxygen consumption (VO2), the reference standard for exercise capacity, in children and young adults with SCA classified by primary pathophysiologic contributor to their decreased exercise capacity, and 2) compare results of this exercise test with the results of previously completed exercise tests to determine longitudinal changes in exercise capacity.
These aims will be performed in 60 subjects with SCA and 30 matched controls who participated in a previous study, IRB# 2009-13659; "The Physiologic Assessment of Exercise Capacity in Pediatric Sickle Cell Anemia".
In a secondary analysis, we will also study the participants quality of life using a set of validated questionnaires.
This study is essential because it will address several areas of exercise capacity, including the longterm effects of physiologic contributors to exercise limitation, that remain fundamental knowledge gaps in SCA.
Study Type
Observational
Enrollment (Anticipated)
90
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Devin S Muntz, BA
- Phone Number: 312-227-4824
- Email: DMuntz@luriechildrens.org
Study Contact Backup
- Name: Jaclyn Janoski, BS, MS, CCRP
- Phone Number: 312-227-4825
- Email: jjanoski@luriechildrens.org
Study Locations
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Illinois
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Chicago, Illinois, United States, 60611
- Recruiting
- Ann & Robert H. Lurie Children's Hospital of Chicago
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Contact:
- Robert I Liem, MD MS
- Phone Number: 312-227-4842
- Email: rliem@luriechildrens.org
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Principal Investigator:
- Robert I Liem, MD MS
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Sub-Investigator:
- Alexis A Thompson, MD MPH
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Sub-Investigator:
- Adrienne Prestridge, MD
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
8 years to 21 years (Child, Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Sickle cell anemia patients followed at Children's Memorial Hospital.
Healthy controls without sickle cell anemia or sickle cell trait are recruited through flyers posted in Children's Memorial Hospital.
Description
Inclusion Criteria:
- age 8 to 21 years old; AND
- Hb SS or S-β0 thalassemia disease, confirmed by hemoglobin analysis; AND
- Previously participated in ClinicalTrials.gov ID: NCT01527799
Exclusion Criteria:
- inability to perform maximal testing due to physical limitation (e.g. stroke or avascular necrosis); OR
- history of exercise-induced syncope or arrhythmias. Subjects will wait at least 2 weeks following any vaso-occlusive pain episode and 12 weeks following any disease-related complication requiring transfusion support. Individuals on hydroxyurea will be eligible. A total of 30 controls without SCA or sickle cell trait will be matched for age, sex and race and recruited from the siblings, friends or relatives of subjects enrolled on this study
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Subjects with sickle cell anemia
60 subjects with sickle cell anemia will be enrolled on the study.
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30 healthy controls
30 controls without sickle cell anemia or sickle cell trait will be enrolled on the study.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
VO2 max on cardiopulmonary exercise test
Time Frame: Baseline
|
Baseline
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Quality of life questionnaires
Time Frame: Baseline
|
Baseline
|
Echocardiogram
Time Frame: Baseline
|
Baseline
|
Dual Energy X-ray Absorbtiometry
Time Frame: Baseline
|
Baseline
|
Pulmonary Function Test
Time Frame: Baseline
|
Baseline
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Principal Investigator: Robert I Liem, MD MS, Ann & Robert H Lurie Children's Hospital of Chicago
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2012
Primary Completion (Anticipated)
December 1, 2016
Study Completion (Anticipated)
December 1, 2016
Study Registration Dates
First Submitted
March 13, 2012
First Submitted That Met QC Criteria
March 16, 2012
First Posted (Estimate)
March 20, 2012
Study Record Updates
Last Update Posted (Estimate)
September 23, 2015
Last Update Submitted That Met QC Criteria
September 21, 2015
Last Verified
September 1, 2015
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2011-14565
- 1K23HL094376 (U.S. NIH Grant/Contract)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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