Glucose as a Mediator of Self-control Performances in Patients With Schizophrenia

March 23, 2012 updated by: The University of Hong Kong

Glucose as a Mediator of Self-control Performances in Patients With Schizophrenia: A Randomized Controlled Study

The research aims to investigate the relationship between self-control ability and blood glucose level in schizophrenic patients. The main purpose of the present study is to explore whether the close relationship of blood glucose and self-regulatory strength observed in healthy individuals, is applicable to schizophrenic patients. More specifically, the current study aims

  • to investigate whether the exertion of self-control reduces blood glucose,
  • to examine whether low level of blood glucose deteriorates subsequent self-control performances
  • to examine whether restoring the glucose level eliminates these impairments, in schizophrenic patients.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

100

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Eric YH Chen, MD
  • Phone Number: 852-22553063
  • Email: eyhchen@hku.hk

Study Contact Backup

Study Locations

  • China
      • Hong Kong, China
        • The University of Hong Kong
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

15 years and older (ADULT, OLDER_ADULT, CHILD)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Aged 15 or above
  • DSM-IV diagnosis of schizophrenia, schizoaffective disorder, schizophreniform psychosis, brief psychosis, psychosis NOS or delusional disorder
  • Cantonese-speaking Chinese
  • Ability to understand the nature of the study and sign informed consent

Exclusion Criteria:

  • Organic Brain disorder
  • Known history of intellectual disability
  • Priority Follow Up (Subtarget or Target)
  • All allergic to any sugar or artificial sweeteners
  • Diabetics
  • Physical Disability

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: TREATMENT
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: DOUBLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: Glucose & Depleting
participants will perform in a depleting task and receive a glucose drink
Dietary supplement: glucose drink
participants will receive a drink rich in glucose
PLACEBO_COMPARATOR: Glucose & non-depleting
participants will perform in a non-depleting task and receive a glucose drink
Dietary supplement: glucose drink
participants will receive a drink rich in glucose
NO_INTERVENTION: Placebo & depleting
participants will perform in a depleting task and receive a placebo drink
NO_INTERVENTION: Placebo & non depleting
participants will perform in a non depleting task and receive a placebo drink

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Blood Glucose Level
Time Frame: baseline, after depleting task
baseline, after depleting task
self control tasks (handgrip, stroop, figure tracing task)
Time Frame: after 12-minutes metabolizing phase
after 12-minutes metabolizing phase

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

The University of Hong Kong

Collaborators

Queen Mary Hospital, Hong Kong

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

April 1, 2012

Primary Completion (ANTICIPATED)

April 1, 2013

Study Completion (ANTICIPATED)

April 1, 2013

Study Registration Dates

First Submitted

March 22, 2012

First Submitted That Met QC Criteria

March 23, 2012

First Posted (ESTIMATE)

March 26, 2012

Study Record Updates

Last Update Posted (ESTIMATE)

March 26, 2012

Last Update Submitted That Met QC Criteria

March 23, 2012

Last Verified

March 1, 2012

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • selfcontrolvsglucose

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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