- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01639560
Varenicline for Light Smokers (ChanLight)
Study Overview
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Phase 4
Contacts and Locations
Study Locations
-
-
Minnesota
-
Rochester, Minnesota, United States, 55905
- Mayo Clinic
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Subjects must be ≥ 18 years of age;
- smokes 5 to 10 CPD for at least 6 months;
- express interest in quitting smoking;
- indicate ability to complete all study visits; and
- provide written informed consent to participate in the study.
- Subject is a female subject of non-childbearing potential or a female subject of childbearing potential - who is using contraceptives and has a negative pregnancy test result;
- Subject is in good health as determined by the investigator;
- Subject has the ability to participate fully in all aspects of the study and keep scheduled appointments.
Exclusion Criteria:
- An active medical condition such as unstable angina, myocardial infarction, or coronary angioplasty within the past 3 months or an untreated cardiac dysrhythmia;
- History of renal failure;
- Cancer [excluding non-melanoma skin cancer] not in remission;
- Psychosis or bipolar disorder;
- Current unstable or untreated moderate or severe depression as assessed by the CES-D;
- have, as defined by the C-SSRS (Columbia-Suicide Severity Rating Scale), current non-specific suicidal thoughts, or have a lifetime history of a suicidal attempt (defined as "potentially self-injurious act committed with at least some wish to die, as a result of act.");
Substance dependence other than nicotine, defined as:
a. Patient has a recent history (past month) of heavy alcohol consumption as defined by NIAAA: i. Men: More than 4 drinks on any day or 14 per week ii. Women: More than 3 drinks on any day or 7 per week. b. Use of cocaine, heroin, club drugs (i.e., MDMA/"ecstasy"), methamphetamine, or hallucinogens (e.g., LSD) at any time during the past month.
c. Use of marijuana on a weekly basis for the past month
- An allergy to varenicline;
- Current use of a behavioral or pharmacologic tobacco dependence treatment and unwilling or unable to discontinue use;
- Another member of their household already participating in this study; and
- Current treatment with another investigational drug (within 30 days of study entry).
- Has an unstable medical condition;
- Subject has untreated hypertension or baseline systolic blood pressure > 180 or diastolic > 100;
- Women of child-bearing potential, or who are pregnant, lactating or likely to become pregnant during the trial and are unwilling to use an acceptable form of contraception during the medication phase will also be excluded. All female subjects of childbearing potential must have a negative pregnancy test and must agree to use approved contraception during participation in the study.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Varenicline
1 mg of varenicline twice per day for 12 weeks.
|
1 mg of varenicline twice per day for 12 weeks and brief behavioral counseling
Other Names:
|
Placebo Comparator: placebo
1 placebo tablet twice a day for 12 weeks
|
1 placebo tablet twice per day for 12 weeks and brief behavioral counseling
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Point Prevalence Smoking Outcome at 12 Weeks (End of Treatment)
Time Frame: 12 weeks
|
To determine the efficacy of 12 weeks of varenicline therapy in achieving increased smoking abstinence rates in light smokers.
Point prevalence is defined as no smoking in the past 7 days.
|
12 weeks
|
Prolonged Smoking Outcome at 12 Weeks (End of Treatment)
Time Frame: 12 weeks
|
To determine the efficacy of 12 weeks of varenicline therapy in achieving increased smoking abstinence rates in light smokers.
Prolonged abstinence is defined as no smoking since 2 weeks after the target quit date.
|
12 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Point Prevalence Smoking Outcome at 24 Weeks (End of Study)
Time Frame: 24 weeks
|
To determine the efficacy of 12 weeks of varenicline therapy in achieving increased smoking abstinence rates at 6 months in light smokers.
Point prevalence is defined as no smoking in the past 7 days.
|
24 weeks
|
Prolonged Smoking Outcome at 24 Weeks (End of Study)
Time Frame: 24 weeks
|
To determine the efficacy of 12 weeks of varenicline therapy in achieving increased smoking abstinence rates at 6 months in light smokers.
Prolonged abstinence is defined as no smoking since 2 weeks after the target quit date.
|
24 weeks
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Ivana T. Croghan, PhD, Mayo Clinic
- Principal Investigator: Jon O. Ebbert, MD, Mayo Clinic
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 12-005652
- WS2293926 (Other Grant/Funding Number: Pfizer Inc)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Smoking
-
University of Southern CaliforniaAmerican Cancer Society, Inc.CompletedSmoking | Smoking Cessation | Smoking, Cigarette | Smoking Behaviors | Cessation, SmokingUnited States
-
University of VirginiaRecruitingSmoking | Smoking Cessation | Smoking Reduction | Smoking, Tobacco | Smoking, Cigarette | Quitting SmokingUnited States
-
University GhentRecruitingSmoking | Smoking Tobacco | Smoking Prevention | Smoking CigaretteBelgium
-
Medical University of South CarolinaCompletedSmoking | Smoking Cessation | Smoking, Tobacco | Smoking, CigaretteUnited States
-
Columbia UniversityNational Cancer Institute (NCI)RecruitingSmoking | Smoking Cessation | Smoking Reduction | Smoking BehaviorsUnited States
-
National Cancer Institute (NCI)CompletedSmoking | Smoking Cessation | Cigarette Smoking | Tobacco, SmokingUnited States
-
Maastricht University Medical CenterThe Investigative Desk; SEO Amsterdam Economics; IVO Research InstituteEnrolling by invitationSmoking Cessation | Smoking Reduction | Smoking, Tobacco | Smoking BehaviorsNetherlands
-
Jennifer Marler, MDCompletedSmoking Cessation | Smoking Reduction | Smoking, Tobacco | Smoking BehaviorsUnited States
-
Medical University of South CarolinaRecruitingSmoking | Smoking Cessation | Tobacco Smoking | Cigarette SmokingUnited States
-
Abramson Cancer Center at Penn MedicineNational Cancer Institute (NCI); New York University; Stanford UniversityRecruitingSmoking | Smoking, Tobacco | Smoking, CigaretteUnited States
Clinical Trials on Varenicline
-
Arizona State UniversityNational Institute on Drug Abuse (NIDA); Pfizer; University of Nevada, Reno; Los...CompletedSmoking Cessation | Withdrawal Symptoms | Tobacco DependenceUnited States
-
PfizerWithdrawn
-
University of California, Los AngelesNational Institute on Drug Abuse (NIDA)CompletedMethamphetamine Addiction | Crystal Meth Addiction | Amphetamine AddictionUnited States
-
Korea University Anam HospitalCompletedHealthyKorea, Republic of
-
Butler HospitalBrown UniversityCompletedDepressive Disorder | SmokingUnited States
-
Medical University of South CarolinaCompletedSmoking | Smoking Cessation | Smoking, Tobacco | Smoking, CigaretteUnited States
-
University of Wisconsin, MadisonNational Cancer Institute (NCI)Enrolling by invitation
-
PfizerCompletedSmoking CessationUnited States, Korea, Republic of, Taiwan, Canada, Georgia, Russian Federation
-
Oyster Point Pharma, Inc.CompletedHealthy SubjectsUnited States