Carbohydrate Use During and Following Exercise (CHO-use)

October 16, 2012 updated by: Maastricht University Medical Center

Sucrose as a Preferred Carbohydrate in Sports Nutrition

Carbohydrates are an integral component of sports nutrition. Providing carbohydrate (CHO) during exercise delays the onset of fatigue and improves exercise performance by maintaining high rates of CHO oxidation. Traditionally, glucose, or glucose polymers have been the preferential CHO source found in sports drinks. However, during the intestinal absorption of large amounts of glucose (>1.2 g/min), sodium-dependent glucose transporters (SGLT1) may become fully saturated, potentially limiting the rate of exogenous CHO oxidation. In an effort to evade this limitation, research has suggested using multiple transportable carbohydrates in the composition of sports drinks. Multiple transportable carbohydrates are combinations of simple sugars that use different intestinal transporters during the absorption process. Ingesting multiple transportable carbohydrates may enhance the capacity for total intestinal CHO absorption, leading to an increase in the rate of exogenous CHO oxidation. Our purpose will be to examine the disaccharide sucrose in it's ability to provide exogenous fuel during and following prolonged exercise.

Study Overview

Study Type

Interventional

Enrollment (Anticipated)

17

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

    • Limburg
      • Maastricht, Limburg, Netherlands, 6200MD
        • Maastricht University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 40 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • Healthy
  • Male
  • 18 - 40 years of age
  • Endurance trained cyclist/triathlete
  • VO2 max ≥ 50 ml/kg/min
  • BMI < 25 kg/m2

Exclusion Criteria:

  • Use of medication
  • Smoking

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Glucose-glucose
Glucose ingestion
Various types of carbohydrate ingested during and following exercise
Active Comparator: Glucose-Fructose
glucose-fructose ingestion
Various types of carbohydrate ingested during and following exercise
Active Comparator: disaccharide
Disaccharide ingestion
Various types of carbohydrate ingested during and following exercise

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Exogenous carbohydrate oxidation rate (Part A)
Time Frame: 0 min during trials 1-3
Carbohydrate oxidation as measured by breath samples
0 min during trials 1-3
Endogenous carbohydrate oxidation (Part A)
Time Frame: 0 min during trials 1-3
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
0 min during trials 1-3
Glycogen utilization (Part B)
Time Frame: immediately post exercise (~90min), during trials 4-6

Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise.

Part B; trials 4-6.

immediately post exercise (~90min), during trials 4-6
Exogenous carbohydrate oxidation rate (Part A)
Time Frame: 30 min during trials 1-3
Carbohydrate oxidation as measured by breath samples
30 min during trials 1-3
Exogenous carbohydrate oxidation rate (Part A)
Time Frame: 60 min during trials 1-3
Carbohydrate oxidation as measured by breath samples
60 min during trials 1-3
Exogenous carbohydrate oxidation rate (Part A)
Time Frame: 90 min during trials 1-3
Carbohydrate oxidation as measured by breath samples
90 min during trials 1-3
Exogenous carbohydrate oxidation rate (Part A)
Time Frame: 120 min during trials 1-3
Carbohydrate oxidation as measured by breath samples
120 min during trials 1-3
Exogenous carbohydrate oxidation rate (Part A)
Time Frame: 150 min during trials 1-3
Carbohydrate oxidation as measured by breath samples
150 min during trials 1-3
Exogenous carbohydrate oxidation rate (Part A)
Time Frame: 180 min during trials 1-3
Carbohydrate oxidation as measured by breath samples
180 min during trials 1-3
Endogenous carbohydrate oxidation (Part A)
Time Frame: 30 min during trials 1-3
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
30 min during trials 1-3
Endogenous carbohydrate oxidation (Part A)
Time Frame: 60 min during trials 1-3
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
60 min during trials 1-3
Endogenous carbohydrate oxidation (Part A)
Time Frame: 90 min during trials 1-3
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
90 min during trials 1-3
Endogenous carbohydrate oxidation (Part A)
Time Frame: 120 min during trials 1-3
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
120 min during trials 1-3
Endogenous carbohydrate oxidation (Part A)
Time Frame: 150 min during trials 1-3
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
150 min during trials 1-3
Endogenous carbohydrate oxidation (Part A)
Time Frame: 180 min during trials 1-3
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
180 min during trials 1-3
Glycogen utilization (Part B)
Time Frame: 3 h post exercise during trials 4-6

Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise.

Part B; trials 4-6.

3 h post exercise during trials 4-6
Glycogen utilization (Part B)
Time Frame: 6 h post exercise during trials 4-6

Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise.

Part B; trials 4-6.

6 h post exercise during trials 4-6

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Indirect calorimetry (Part A)
Time Frame: every 30 min up to 180 min during trials 1-3
Measurements of VO2, VCO2 and RER through indirect calorimetry measured every 30 minutes during trials 1-3
every 30 min up to 180 min during trials 1-3
Plasma glucose
Time Frame: every 30 min up to 180 min during trials 1-6
Plasma glucose measurements
every 30 min up to 180 min during trials 1-6
Plasma insulin
Time Frame: every 30 minutes up to 180 min during trials 1-6
plasma insulin measurements
every 30 minutes up to 180 min during trials 1-6

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Investigators

  • Principal Investigator: Luc van Loon, Ph.D., Maastricht University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

November 1, 2012

Primary Completion (Anticipated)

September 1, 2013

Study Completion (Anticipated)

January 1, 2014

Study Registration Dates

First Submitted

October 11, 2012

First Submitted That Met QC Criteria

October 16, 2012

First Posted (Estimate)

October 18, 2012

Study Record Updates

Last Update Posted (Estimate)

October 18, 2012

Last Update Submitted That Met QC Criteria

October 16, 2012

Last Verified

October 1, 2012

More Information

Terms related to this study

Other Study ID Numbers

  • 12-3-048

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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