- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01709617
Carbohydrate Use During and Following Exercise (CHO-use)
October 16, 2012 updated by: Maastricht University Medical Center
Sucrose as a Preferred Carbohydrate in Sports Nutrition
Carbohydrates are an integral component of sports nutrition.
Providing carbohydrate (CHO) during exercise delays the onset of fatigue and improves exercise performance by maintaining high rates of CHO oxidation.
Traditionally, glucose, or glucose polymers have been the preferential CHO source found in sports drinks.
However, during the intestinal absorption of large amounts of glucose (>1.2 g/min), sodium-dependent glucose transporters (SGLT1) may become fully saturated, potentially limiting the rate of exogenous CHO oxidation.
In an effort to evade this limitation, research has suggested using multiple transportable carbohydrates in the composition of sports drinks.
Multiple transportable carbohydrates are combinations of simple sugars that use different intestinal transporters during the absorption process.
Ingesting multiple transportable carbohydrates may enhance the capacity for total intestinal CHO absorption, leading to an increase in the rate of exogenous CHO oxidation.
Our purpose will be to examine the disaccharide sucrose in it's ability to provide exogenous fuel during and following prolonged exercise.
Study Overview
Status
Unknown
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
17
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Naomi Cermak, Ph.D.
- Phone Number: 31433881393
- Email: naomi.cermak@maastrichtuniversity.nl
Study Locations
-
-
Limburg
-
Maastricht, Limburg, Netherlands, 6200MD
- Maastricht University
-
Contact:
- Email: ncermak@gmail.com
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 40 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Male
Description
Inclusion Criteria:
- Healthy
- Male
- 18 - 40 years of age
- Endurance trained cyclist/triathlete
- VO2 max ≥ 50 ml/kg/min
- BMI < 25 kg/m2
Exclusion Criteria:
- Use of medication
- Smoking
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Glucose-glucose
Glucose ingestion
|
Various types of carbohydrate ingested during and following exercise
|
Active Comparator: Glucose-Fructose
glucose-fructose ingestion
|
Various types of carbohydrate ingested during and following exercise
|
Active Comparator: disaccharide
Disaccharide ingestion
|
Various types of carbohydrate ingested during and following exercise
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Exogenous carbohydrate oxidation rate (Part A)
Time Frame: 0 min during trials 1-3
|
Carbohydrate oxidation as measured by breath samples
|
0 min during trials 1-3
|
Endogenous carbohydrate oxidation (Part A)
Time Frame: 0 min during trials 1-3
|
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
|
0 min during trials 1-3
|
Glycogen utilization (Part B)
Time Frame: immediately post exercise (~90min), during trials 4-6
|
Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise. Part B; trials 4-6. |
immediately post exercise (~90min), during trials 4-6
|
Exogenous carbohydrate oxidation rate (Part A)
Time Frame: 30 min during trials 1-3
|
Carbohydrate oxidation as measured by breath samples
|
30 min during trials 1-3
|
Exogenous carbohydrate oxidation rate (Part A)
Time Frame: 60 min during trials 1-3
|
Carbohydrate oxidation as measured by breath samples
|
60 min during trials 1-3
|
Exogenous carbohydrate oxidation rate (Part A)
Time Frame: 90 min during trials 1-3
|
Carbohydrate oxidation as measured by breath samples
|
90 min during trials 1-3
|
Exogenous carbohydrate oxidation rate (Part A)
Time Frame: 120 min during trials 1-3
|
Carbohydrate oxidation as measured by breath samples
|
120 min during trials 1-3
|
Exogenous carbohydrate oxidation rate (Part A)
Time Frame: 150 min during trials 1-3
|
Carbohydrate oxidation as measured by breath samples
|
150 min during trials 1-3
|
Exogenous carbohydrate oxidation rate (Part A)
Time Frame: 180 min during trials 1-3
|
Carbohydrate oxidation as measured by breath samples
|
180 min during trials 1-3
|
Endogenous carbohydrate oxidation (Part A)
Time Frame: 30 min during trials 1-3
|
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
|
30 min during trials 1-3
|
Endogenous carbohydrate oxidation (Part A)
Time Frame: 60 min during trials 1-3
|
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
|
60 min during trials 1-3
|
Endogenous carbohydrate oxidation (Part A)
Time Frame: 90 min during trials 1-3
|
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
|
90 min during trials 1-3
|
Endogenous carbohydrate oxidation (Part A)
Time Frame: 120 min during trials 1-3
|
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
|
120 min during trials 1-3
|
Endogenous carbohydrate oxidation (Part A)
Time Frame: 150 min during trials 1-3
|
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
|
150 min during trials 1-3
|
Endogenous carbohydrate oxidation (Part A)
Time Frame: 180 min during trials 1-3
|
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
|
180 min during trials 1-3
|
Glycogen utilization (Part B)
Time Frame: 3 h post exercise during trials 4-6
|
Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise. Part B; trials 4-6. |
3 h post exercise during trials 4-6
|
Glycogen utilization (Part B)
Time Frame: 6 h post exercise during trials 4-6
|
Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise. Part B; trials 4-6. |
6 h post exercise during trials 4-6
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Indirect calorimetry (Part A)
Time Frame: every 30 min up to 180 min during trials 1-3
|
Measurements of VO2, VCO2 and RER through indirect calorimetry measured every 30 minutes during trials 1-3
|
every 30 min up to 180 min during trials 1-3
|
Plasma glucose
Time Frame: every 30 min up to 180 min during trials 1-6
|
Plasma glucose measurements
|
every 30 min up to 180 min during trials 1-6
|
Plasma insulin
Time Frame: every 30 minutes up to 180 min during trials 1-6
|
plasma insulin measurements
|
every 30 minutes up to 180 min during trials 1-6
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Luc van Loon, Ph.D., Maastricht University
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
November 1, 2012
Primary Completion (Anticipated)
September 1, 2013
Study Completion (Anticipated)
January 1, 2014
Study Registration Dates
First Submitted
October 11, 2012
First Submitted That Met QC Criteria
October 16, 2012
First Posted (Estimate)
October 18, 2012
Study Record Updates
Last Update Posted (Estimate)
October 18, 2012
Last Update Submitted That Met QC Criteria
October 16, 2012
Last Verified
October 1, 2012
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 12-3-048
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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