Carbohydrate Use During and Following Exercise

Sucrose as a Preferred Carbohydrate in Sports Nutrition

Sponsors

Lead Sponsor: Maastricht University Medical Center

Source Maastricht University Medical Center
Brief Summary

Carbohydrates are an integral component of sports nutrition. Providing carbohydrate (CHO) during exercise delays the onset of fatigue and improves exercise performance by maintaining high rates of CHO oxidation. Traditionally, glucose, or glucose polymers have been the preferential CHO source found in sports drinks. However, during the intestinal absorption of large amounts of glucose (>1.2 g/min), sodium-dependent glucose transporters (SGLT1) may become fully saturated, potentially limiting the rate of exogenous CHO oxidation. In an effort to evade this limitation, research has suggested using multiple transportable carbohydrates in the composition of sports drinks. Multiple transportable carbohydrates are combinations of simple sugars that use different intestinal transporters during the absorption process. Ingesting multiple transportable carbohydrates may enhance the capacity for total intestinal CHO absorption, leading to an increase in the rate of exogenous CHO oxidation. Our purpose will be to examine the disaccharide sucrose in it's ability to provide exogenous fuel during and following prolonged exercise.

Overall Status Unknown status
Start Date 2012-11-01
Completion Date 2014-01-01
Primary Completion Date 2013-09-01
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
Exogenous carbohydrate oxidation rate (Part A) 0 min during trials 1-3
Endogenous carbohydrate oxidation (Part A) 0 min during trials 1-3
Glycogen utilization (Part B) immediately post exercise (~90min), during trials 4-6
Exogenous carbohydrate oxidation rate (Part A) 30 min during trials 1-3
Exogenous carbohydrate oxidation rate (Part A) 60 min during trials 1-3
Exogenous carbohydrate oxidation rate (Part A) 90 min during trials 1-3
Exogenous carbohydrate oxidation rate (Part A) 120 min during trials 1-3
Exogenous carbohydrate oxidation rate (Part A) 150 min during trials 1-3
Exogenous carbohydrate oxidation rate (Part A) 180 min during trials 1-3
Endogenous carbohydrate oxidation (Part A) 30 min during trials 1-3
Endogenous carbohydrate oxidation (Part A) 60 min during trials 1-3
Endogenous carbohydrate oxidation (Part A) 90 min during trials 1-3
Endogenous carbohydrate oxidation (Part A) 120 min during trials 1-3
Endogenous carbohydrate oxidation (Part A) 150 min during trials 1-3
Endogenous carbohydrate oxidation (Part A) 180 min during trials 1-3
Glycogen utilization (Part B) 3 h post exercise during trials 4-6
Glycogen utilization (Part B) 6 h post exercise during trials 4-6
Secondary Outcome
Measure Time Frame
Indirect calorimetry (Part A) every 30 min up to 180 min during trials 1-3
Plasma glucose every 30 min up to 180 min during trials 1-6
Plasma insulin every 30 minutes up to 180 min during trials 1-6
Enrollment 17
Condition
Intervention

Intervention Type: Dietary Supplement

Intervention Name: Carbohydrate ingestion

Description: Various types of carbohydrate ingested during and following exercise

Eligibility

Criteria:

Inclusion Criteria: - Healthy - Male - 18 - 40 years of age - Endurance trained cyclist/triathlete - VO2 max ≥ 50 ml/kg/min - BMI < 25 kg/m2 Exclusion Criteria: - Use of medication - Smoking

Gender:

Male

Minimum Age:

18 Years

Maximum Age:

40 Years

Healthy Volunteers:

Accepts Healthy Volunteers

Overall Official
Last Name Role Affiliation
Luc van Loon, Ph.D. Principal Investigator Maastricht University
Overall Contact Contact information is only displayed when the study is recruiting subjects.
Location
Facility: Contact: Maastricht University [email protected]
Location Countries

Netherlands

Verification Date

2012-10-01

Responsible Party

Type: Sponsor

Keywords
Has Expanded Access No
Number Of Arms 3
Arm Group

Label: Glucose-glucose

Type: Experimental

Description: Glucose ingestion

Label: Glucose-Fructose

Type: Active Comparator

Description: glucose-fructose ingestion

Label: disaccharide

Type: Active Comparator

Description: Disaccharide ingestion

Acronym CHO-use
Study Design Info

Allocation: Randomized

Intervention Model: Crossover Assignment

Masking: Double (Participant, Investigator)

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