The Effect of Consuming a guaraná and Vitamin/Mineral Complex Pre-exercise on Affect, Exertion, Metabolism and Cognition

The Effect of Consuming a Guaraná and Vitamin and Mineral Complex Before a Morning Exercise Session on Affect, Exertion and Substrate Metabolism During Exercise and Cognitive Performance During the Post-exercise Recovery Period

Consuming a guaraná and vitamin and mineral complex can improve mental fatigue and cognitive function at rest; guaraná also contains caffeine, which can reduce perceived exertion and increase fat burning during exercise. The purpose of this study is to test whether consuming a guaraná and vitamin and mineral product before exercise influences affect (mood), physical exertion and fat burning during exercise and mental fatigue, cognitive performance and affect post-exercise.

Study Overview

• Status: Completed
• Conditions: Affect and Exertion During and Post-exercise
• Intervention / Treatment: Dietary supplement: Placebo; Dietary supplement: Berocca Boost

• Study Type: Interventional
• Enrollment (Actual): 40
• Phase: Phase 4

Contacts and Locations

Study Locations

• United Kingdom
  • Tyne and Wear
    • Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE18ST
      • Brain, Performance and Nutrition Research Centre, Northumbria Univerity

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

Individuals must be:

• Healthy
• Male
• Aged between 18 and 35years
• Habitually active (exercising at least twice a week)
• Able to run at a moderate pace for 30 minutes non-stop on a treadmill

Exclusion Criteria:

Individuals will not be eligible to take part in this study if they:

• have a history of neurological or psychiatric diseases excluding anxiety or depression
• have a current diagnosis of depression or anxiety
• have a history of significant head trauma, metabolic, endocrine or cardiac disorders
• have smoked within the last 3 months,
• have high blood pressure >140/90mmHg
• consume > 500 mg caffeine per day from all dietary sources
• have adverse reactions to caffeine containing products (i.e. tea, coffee, energy drinks, cola, Pepsi)
• are currently taking any pharmaceuticals
• have habitual taken dietary supplements within the last 4 weeks (defined as ≥3 consecutive days or ≥4 days in total per week)
• have current or history of drug or alcohol abuse
• have participated in another clinical trial within 30 days prior to screening
• have any condition which may interfere with your ability to perform assessments
• have any history of hypersensitivity to the investigational product or its active or inactive constituents or any food allergy or intolerance

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Quadruple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Berocca Boost; Guarana and vitamin and mineral complex, one tablet dissolved in 250ml water taken once.	Dietary supplement: Berocca Boost
Placebo Comparator: Placebo; Matched placebo tablet, one tablet dissolved in 250ml water taken once.	Dietary supplement: Placebo

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Affect	Affect measured using the Feeling Scale and Felt Arousal Scale	Assessed pre-exercise, at 10min intervals during exercise and 45 and 75min post-exercise

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Exertion	Rate of perceived exertion measured using the Borg scale	Measured at 10min intervals during exercise

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cognitive Function	Participants will complete a set of cognitive tasks (Immediate Word Recall, Choice Reaction Time, Rapid visual information processing task, Numeric Working Memory, Delayed word Recall, Word Recognition and Picture Recognition) measuring episodic memory, working memory, attention and decision making.	Assessed at baseline, pre-exercise and immeadiately and 75min post-exercise
Mood	Assessed using the Bond-Lader Visual Analogue Scales (VAS) and Energy VAS (concentration, physical stamina, mental stamina)	Assessed at baseline, pre-exercise and immeadiately and 75min post-exercise
Substrate Metabolism	Measured using an online gas analysis system (Cortex). Oxygen uptake, carbon dioxide production, fat and carbohydrate oxidation and energy expenditure will be measured for 1 min at each 10min interval.	Measured at 10min intervals during exercise

Collaborators and Investigators

• Sponsor: Northumbria University
• Collaborators: Bayer
• Investigators: Principal Investigator: Rachel Veasey, MSc, Northumbria University

Study record dates

Study Major Dates

• Study Start: September 1, 2013
• Primary Completion (Actual): April 1, 2014
• Study Completion (Actual): April 1, 2014

Study Registration Dates

• First Submitted: August 19, 2013
• First Submitted That Met QC Criteria: August 21, 2013
• First Posted (Estimate): August 28, 2013

Study Record Updates

• Last Update Posted (Estimate): October 3, 2014
• Last Update Submitted That Met QC Criteria: October 2, 2014
• Last Verified: October 1, 2014

More Information

Terms related to this study

• Other Study ID Numbers: 9B2