Pilot Study for Noninvasive Spectroscopic Detection of Adipose Tissue Inflammation in Obesity

September 16, 2016 updated by: Rockefeller University
This study will test the potential of two techniques using light properties of adipose tissue to diagnose crown-like structures and inflammation to be compared with pathologic examination of adipose tissue biopsies from ongoing clinical studies.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Adipose tissue (fat) inflammation is emerging as an important harbinger of disease development including Type 2 diabetes, heart disease and potentially cancer. The hallmark feature of adipose tissue inflammation is the crown-like structure, a dying fat cell surrounded by immune cells attempting to clear the damage. Current methods for detecting adipose tissue inflammation rely on invasive procedures such as fat biopsies. We propose developing methods that use the light reflection properties of inflamed adipose tissue as a potential non-invasive method to detect adipose tissue inflammation.

Study Type

Observational

Enrollment (Actual)

14

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

    • New York
      • New York, New York, United States, 10065
        • The Rockefeller University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 70 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Healthy Volunteer and obese subjects

Description

Inclusion Criteria:

-Subjects currently enrolled in a current Rockefeller University study who will be undergoing adipose tissue biopsies as part of the study protocol

Exclusion Criteria:

-History of any skin disease

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Obese subjects for fat biopsy
10 patients recruited during fat biopsies for sample collection
Fat biopsy
Lean controls for fat biopsy
5 Lean controls will be recruited
Fat biopsy

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy
Time Frame: 1 day
Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy
1 day

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Steady state oxygenation at the site of tissue biopsy by Diffuse Reflectance Spectroscopy
Time Frame: 1 day
Steady state oxygenation at the site of tissue biopsy by Diffuse Reflectance Spectroscopy
1 day

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Investigators

  • Principal Investigator: Jose Aleman, MD PhD, Rockefeller Univesrity

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2013

Primary Completion (ACTUAL)

August 1, 2016

Study Completion (ACTUAL)

August 1, 2016

Study Registration Dates

First Submitted

July 11, 2013

First Submitted That Met QC Criteria

July 11, 2013

First Posted (ESTIMATE)

July 16, 2013

Study Record Updates

Last Update Posted (ESTIMATE)

September 19, 2016

Last Update Submitted That Met QC Criteria

September 16, 2016

Last Verified

September 1, 2016

More Information

Terms related to this study

Other Study ID Numbers

  • JAL-0809

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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