Influence of Adipocytokines in Osteoarthritis

November 7, 2013 updated by: Joan Calvet Fontova, Hospital Parc Taulí, Sabadell

Adipocytokines Influence on Clinical and Ultrasonographic Inflammatory Activity in Patients With Knee Osteoarthritis

Adipocytokines play an important role in joint inflammation in patients with knee osteoarthritis as measured by ultrasound and high sensitivity protein-C reactive. Adipocytokines could be the link between osteoarthritis and cardiovascular risk factors more prevalent in these patients.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Anticipated)

105

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Spain
    • Barcelona
      • Sabadell, Barcelona, Spain, 08208
        • Recruiting
        • Hospital Parc Tauli
      • Sabadell, Barcelona, Spain, 08208
        • Recruiting
        • Hospital Parc Tauli Sabadell

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

50 years to 80 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

patients over 50 years who were referred for rheumatology for symptomatic knee osteoarthritis.

Description

Inclusion Criteria:

  • Patients over 50 years old with symptomatic knee osteoarthritis.

Exclusion Criteria:

  • Patients with secondary osteoarthritis of the knee
  • Any other rheumatologic condition.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Inflammatory knee osteoarthritis
One group of patients with inflammatory condition in physical evaluation. We will make a blood analyse and arthrocentesis when synovial fluid were found in ultrasound examination. Ultrasound of affected knee and carotid artery will be performed.
Other: Blood analyse, arthrocentesis, ultrasound examination
Non-inflammatory knee osteoarthritis
Patients with no inflammatory condition in physical examination. We will make a blood analyse and arthrocentesis when synovial fluid were found in ultrasound examination. Ultrasound of affected knee and carotid artery will be performed.
Other: Blood analyse, arthrocentesis, ultrasound examination

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
adipocytokine level
Time Frame: 18 months
We will determine the adipocytokine level at the end of inclusion period between 12-18 months
18 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Ultrasound inflammatory exploration of the knee
Time Frame: 18 months
we evaluate the presence of synovial fluid with ultrasound evaluation in the visit of the patient. Ultrasound evaluation will be performed by two Rheumatologists.
18 months
Ultrasound of carotid artery
Time Frame: 18 months
We will evaluate patients with ultrasound exploration in order to describe the presence of atheromatous disease in the visit of the patient
18 months
Cardiovascular risk factors
Time Frame: 18months
We evaluate the prevalence of cardiovascular risk factors in the symptomatic knee osteoarthritis patients, and the relationship with adipocytokines. We will evaluate blood analyse levels of cholesterol, glycemia.
18months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hospital Parc Taulí, Sabadell

Investigators

  • Study Director: jordi Gratacos, MD Ph, Hospital Parc Tauli

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

July 1, 2013

Primary Completion (ANTICIPATED)

November 1, 2014

Study Completion (ANTICIPATED)

December 1, 2014

Study Registration Dates

First Submitted

July 5, 2013

First Submitted That Met QC Criteria

July 19, 2013

First Posted (ESTIMATE)

July 24, 2013

Study Record Updates

Last Update Posted (ESTIMATE)

November 8, 2013

Last Update Submitted That Met QC Criteria

November 7, 2013

Last Verified

November 1, 2013

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Joan01

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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