- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02199990
The Effect of Propofol or Etomidate on Cognitive Function for 1-3 Years Old Children
July 23, 2014 updated by: hong yi Jiang,MD, Guilin Medical University, China
the Study of Propofol or Etomidate Affecting to the Cognitive Function for 1-3 Years Old Children in the 7 Days and 3 Months.
Based on China's guangxi guilin for a hernia operation in 1 to 3 years old preschool children propofol and etomidate on behavioral and cognitive function after intravenous anesthesia in according to beta protein in serum and plasma glutamate (Glutamic acid, Glu) and gamma-aminobutyric acid (Gamma aminobutyric acid, GABA) level of observation, the rapid development period children's cognitive function after anesthesia short-term and long-term change process and its possible mechanism is studied, for the current international debate on "anesthetics effects on developing kids brain nerve" research hot spot in the city of clinical basis and research argument, for pediatric anesthesia clinical safety, provide theoretical basis for the rational use of drugs.
Study Overview
Status
Unknown
Conditions
Detailed Description
- by selecting the aged 1 to 3, 100 cases of patients with elective surgery, were randomly divided into the propofol group (P group), the etomidate group (group E), all the 50 cases, healthy age 50 cases of children (blank control group, group C) were studied;
- the children's intelligence equation of the People's Republic of China neuropsychological test: P, E group of preoperative 1 day before operation, postoperative day 3, 3 months neuropsychological test, observe and evaluate patients POCD is happening; Correspond to the experimental group in the same period in group C, i.e., the first test (1 d) preoperatively, 4 days after the second test (3 d) after operation, 3 months after the third test (3 months), observed and compared with experimental neuropsychological testing of variation;
- laboratory of brain damage index determination: extract internal jugular venous blood in preoperative and perioperative finish 5 ml, with double antibody immune sandwich enzyme-linked immunosorbent (ELISA) method of determination of serum S - 100 beta protein levels, rapid determination of amino acid analyzer, plasma Glu, GABA levels;
- statistical analysis: use SPSS13.0 statistical software for children with cognitive function before and after operation and serum S - 100 beta protein and serum Glu, GABA levels change research results should carry on the analysis of variance, P < 0.05 for statistical significance.
- clear rapid development period of infants receive propofol and etomidate on plasma according to beta protein after intravenous anesthesia and Glu, GABA expression and its relationship between the change of cognitive function and clarify all according to propofol and etomidate intravenous anesthesia on the brain is in rapid development period of infant short-term and long-term postoperative cognitive function and its possible mechanism, the influence of safety for children suffering from anesthesia, and to provide theoretical basis for the rational use of drugs.
Study Type
Observational
Enrollment (Anticipated)
150
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: xun lei, MD
- Phone Number: (86)0773-5895812
- Email: leixun@glmc.edu.cn
Study Locations
-
-
Guangxi
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Guilin, Guangxi, China, 541004
- Recruiting
- Guilin Medical University
-
Contact:
- hong yi Jiang, MD
- Phone Number: 013607736057
- Email: jiangyihong6@163.com
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
1 year to 3 years (Child)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
1.Guilin 1-3 years due to hernia surgery to receive propofol or etomidate total intravenous anesthesia in children.
2.1-3 years old healthy children in 4 kindergartens of different level of teachers in the Guilin city.
Description
Inclusion Criteria:
- Signed informed consent; elective laparoscopic hernia repair and appendectomy and other non cardiac operation and Department of cerebral surgery; age 1-3; ASA grade I~II;
Exclusion Criteria:
- Heart, lung, liver, kidney function was abnormal; she has a history of asthma, central nervous system diseases, congenital disorders, hyperactivity, anesthesia operation history; there are factors to evaluate any impact cognitive functions such as language, severe visual and hearing impairment; expected before surgery in patients with delayed extubation; any reason not to cooperate to complete the whole test; perioperative bleeding again; postoperative anesthesia operation; operation time >1h; extubation in patients with delayed; quit by researchers in the process of.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Case-Control
- Time Perspectives: Prospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The concentration of serum S100 β protein
Time Frame: One hour before anesthesia, one hour after the end of anesthesia.
|
Respectively one hour before anesthesia, anesthesia for one hour 5 ml of blood from the jugular vein, serum S100β protein concentration.
|
One hour before anesthesia, one hour after the end of anesthesia.
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Plasma levels of Glutamic acid(Glu) and Gamma-aminobutyric acid(GABA) concentration.
Time Frame: One hour before anesthesia, one hour after the end of anesthesia.
|
Respectively one hour before anesthesia, one hour after the end of anesthesia 5 ml of blood from the jugular vein, , plasma Glu, GABA concentration.
|
One hour before anesthesia, one hour after the end of anesthesia.
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The test results of neuropsychology
Time Frame: One day before the operation, third days after the operation, third months after the operation
|
Use of "Chinese children's intelligence equation" for young children tested cognitive function evaluation.The test point in time:One day before the operation, third days after the operation, third months after the operation.
|
One day before the operation, third days after the operation, third months after the operation
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Director: Lei xun, MD, Guilin Medical University, China
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
July 1, 2014
Primary Completion (Anticipated)
July 1, 2015
Study Completion (Anticipated)
July 1, 2015
Study Registration Dates
First Submitted
July 20, 2014
First Submitted That Met QC Criteria
July 23, 2014
First Posted (Estimate)
July 25, 2014
Study Record Updates
Last Update Posted (Estimate)
July 25, 2014
Last Update Submitted That Met QC Criteria
July 23, 2014
Last Verified
July 1, 2014
More Information
Terms related to this study
Other Study ID Numbers
- 49850254-1
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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