Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.

Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.

Sponsors

Lead Sponsor: Hangzhou Normal University

Source Hangzhou Normal University
Brief Summary

It is just an observation study. The investigates want to explore the signal changes of resting state functional Magnetic resonance Imaging (fMRI) after light treatment in jaundice infants. Signal changes contain blood oxygenation level dependent (BOLD) and arterial spin labeling (ASL).Indicator of BOLD is amplitude of low-frequency fluctuation(ALFF).Indicator of ASL is cerebral blood flow (CBF).

The investigates assume that the children with jaundice after light therapy, ALFF and CBF will change. Focus on the globus pallidus and subthalamic nuclei. The two brain regions were proved to be abnormal in MRI T1, T2 structure signal in kernicterus.

Doctors observe the status of infants aside.Using monitoring probe can see clearly.

Detailed Description

resting state fMRI scan light therapy the second time resting state fMRI scan

Overall Status Unknown status
Start Date August 2014
Completion Date July 2015
Primary Completion Date March 2015
Study Type Observational
Primary Outcome
Measure Time Frame
amplitude of low-frequency fluctuation change before and after light treatment before and after light treatment
Secondary Outcome
Measure Time Frame
cerebral blood flow change before after light treatment before and after light treatment
Enrollment 20
Condition
Intervention

Intervention Type: Device

Intervention Name: light treatment

Description: clinical routine treatment according to the doctor's advice

Arm Group Label: light treatment

Eligibility

Sampling Method: Non-Probability Sample

Criteria:

Inclusion Criteria:

- hyperbilirubinemia

Exclusion Criteria:

- asphyxia

- cerebral dysgenesis

Gender: All

Minimum Age: N/A

Maximum Age: 28 Days

Healthy Volunteers: No

Overall Official
Last Name Role Affiliation
Ya-Fei Zhu Principal Investigator Center for Cognition and Brain Disorders,Hangzhou Normal University
Overall Contact

Last Name: Xiao-Bao Xue

Email: [email protected]

Location
Facility: Status: Contact: Investigator: Center for Cognition and Brain Disorders Xiao-Bao Xue [email protected] Ya-Fei Zhu Principal Investigator
Location Countries

China

Verification Date

August 2014

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Hangzhou Normal University

Investigator Full Name: Ya-Fei Zhu

Investigator Title: chief physician

Has Expanded Access No
Condition Browse
Arm Group

Label: light treatment

Description: clinical routine treatment according to the doctor's advice

Study Design Info

Observational Model: Case-Crossover

Time Perspective: Prospective

Source: ClinicalTrials.gov