Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.

August 21, 2014 updated by: Ya-Fei Zhu, Hangzhou Normal University

It is just an observation study. The investigates want to explore the signal changes of resting state functional Magnetic resonance Imaging (fMRI) after light treatment in jaundice infants. Signal changes contain blood oxygenation level dependent (BOLD) and arterial spin labeling (ASL).Indicator of BOLD is amplitude of low-frequency fluctuation（ALFF).Indicator of ASL is cerebral blood flow (CBF).

The investigates assume that the children with jaundice after light therapy, ALFF and CBF will change. Focus on the globus pallidus and subthalamic nuclei. The two brain regions were proved to be abnormal in MRI T1, T2 structure signal in kernicterus.

Doctors observe the status of infants aside.Using monitoring probe can see clearly.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

resting state fMRI scan light therapy the second time resting state fMRI scan

Study Type

Observational

Enrollment (Anticipated)

20

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • China
    • Zhejiang
      • Hangzhou, Zhejiang, China, 311121
        • Recruiting
        • Center for Cognition and Brain Disorders
        • Contact:
        • Principal Investigator:
          • Ya-Fei Zhu

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

1 day to 4 weeks (Child)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

municipal hospitals

Description

Inclusion Criteria:

  • hyperbilirubinemia

Exclusion Criteria:

  • asphyxia
  • cerebral dysgenesis

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
light treatment
clinical routine treatment according to the doctor's advice
Device: light treatment
clinical routine treatment according to the doctor's advice

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
amplitude of low-frequency fluctuation change before and after light treatment
Time Frame: before and after light treatment
It is indicator of blood oxygenation level dependent.
before and after light treatment

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
cerebral blood flow change before after light treatment
Time Frame: before and after light treatment
It is indicator of arterial spin labeling.
before and after light treatment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hangzhou Normal University

Investigators

  • Principal Investigator: Ya-Fei Zhu, Center for Cognition and Brain Disorders,Hangzhou Normal University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2014

Primary Completion (Anticipated)

March 1, 2015

Study Completion (Anticipated)

July 1, 2015

Study Registration Dates

First Submitted

August 20, 2014

First Submitted That Met QC Criteria

August 21, 2014

First Posted (Estimate)

August 25, 2014

Study Record Updates

Last Update Posted (Estimate)

August 25, 2014

Last Update Submitted That Met QC Criteria

August 21, 2014

Last Verified

August 1, 2014

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • HNU_AH_jaundice fMRI

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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