Usefulness of Neutrophil Gelatinase-associated Lipocalin(NGAL) to Confirm Acute Kidney Function Decrease of the Patients Who Had Non-cardiac Surgery

Although post-op renal function decrease is determined by serum creatinine, serum creatinine has disadvantages that it increases a long time after renal function decrease and it has various increasing time based on the level of renal function. Neutrophil Gelatinase-associated Lipocalin (NGAL's) usefulness as an evidence for acute kidney damage occurring from post-op cardiac surgery, being critical patients and contrast medium use is already proven.

But NGAL's usefulness for renal function after non-cardiac surgery is not proven and especially, NGAL's usefulness for renal injury after non-cardiac surgery in chronic renal disease patients is not proven.Therefore, the investigators will study about renal function decrease after non-cardiac surgery with NGAL and serum creatinine.

Study Overview

• Status: Completed
• Conditions: Chronic Kidney Disease
• Intervention / Treatment: Other: The level of NGAL after pre op,post op 4hr, post op 12hr

• Study Type: Observational
• Enrollment (Actual): 43

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 79 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

43 patients who had non-cardiac surgery in Seoul Paik Hospital.

Description

Inclusion Criteria:

• 43 patients who had non-cardiac surgery in Seoul Paik Hospital.

Exclusion Criteria:

• have viral hepatitis and Aspartate aminotransferase, Alanine aminotransferase > 2 time of normal level
• severe lung disease
• severe heart failure ( Ejection Fraction < 40% )
• pregnancy

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
kidney function normal group; kidney function normal group : defined by the normal level of NGAL after post operation 4hrs	Other: The level of NGAL after pre op,post op 4hr, post op 12hr
kidney function decreased group; kidney function decreased group : defined by the increased level of NGAL after post operation 4hrs	Other: The level of NGAL after pre op,post op 4hr, post op 12hr

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
serum NGAL level	up to post operation 12 hours

Collaborators and Investigators

• Sponsor: Inje University

Study record dates

Study Major Dates

• Study Start: February 1, 2014
• Primary Completion (Actual): August 1, 2014

Study Registration Dates

• First Submitted: September 1, 2014
• First Submitted That Met QC Criteria: September 5, 2014
• First Posted (Estimate): September 8, 2014

Study Record Updates

• Last Update Posted (Estimate): September 8, 2014
• Last Update Submitted That Met QC Criteria: September 5, 2014
• Last Verified: September 1, 2014

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Urologic Diseases; Renal Insufficiency; Kidney Diseases; Renal Insufficiency, Chronic
• Other Study ID Numbers: postOPNGAL01