- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02337452
Web-Based Family Outreach Program for Cancer Prevention in High-Risk Families
The Patient-Driven Self-Navigated Web-Based Family Outreach Program for Cancer Prevention in High-Risk Families
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
PRIMARY OBJECTIVES:
I. To develop a secure, web-based program for family outreach in Clinical Cancer Genetics (CCG).
II. The long-term goals of this program are expected to include, but are not limited to the following:
IIa. To enable families with inherited cancer susceptibility and/or at increased familial risk of cancer to provide personal and family history of neoplasia through a convenient and self-directed program.
IIb. To enable communication of possible inherited cancer susceptibility with and among family members through the web-based portal.
IIc. To facilitate genetic testing, screening and prevention strategies in those at risk.
IId. Establish high-risk cohort for optional participation in research and clinical trials.
OUTLINE:
Patients communicate with at-risk family members to share genetic test results and other relevant information, as well as to learn more about their disease via family outreach program website. At risk family members are then contacted by a study coordinator or genetic counselor for further follow-up. At-risk relatives receive resources to facilitate understanding of their at-risk status and to facilitate predictive testing.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Contact
- Name: Patrick M Lynch
- Phone Number: 713-794-5073
- Email: plynch@mdanderson.org
Study Locations
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Texas
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Houston, Texas, United States, 77030
- M D Anderson Cancer Center
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Individuals who have been diagnosed with a hereditary cancer-causing mutation. Individuals may be identified through clinical testing as patients at MD Anderson or patients whose mutation was identified at an outside institution who contact the registry
- Individuals that have clinical suspicion for syndromic cancer susceptibility, but in whom mutational testing has been nondiagnostic (depending on condition in question, nondiagnostic testing may be as little as 10%, as in familial adenomatous polyposis [FAP], or as high as 70% in suspected hereditary diffuse gastric cancer or HDGC)
- At-risk family members of individuals with a cancer causing mutation or of individuals with nondiagnostic testing notwithstanding presence of likely syndromic cancer. Such patients will in most cases not be MD Anderson patients. Note: The enrollment, consenting, and evaluation process anticipates and addresses this.
Exclusion Criteria:
- Index patients who test negative for a cancer causing mutation, except for those agreeing to provide family history (FH) that is informative for at-risk individuals when no other source of such information is available
- Patients who are unwilling or are unable to provide informed consent
Study Plan
How is the study designed?
Design Details
- Observational Models: Family-Based
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Observational (family outreach program)
Patients communicate with at-risk family members to share genetic test results and other relevant information, as well as to learn more about their disease via family outreach program website.
At risk family members are then contacted by a study coordinator or genetic counselor for further follow up.
At-risk relatives receive resources to facilitate understanding of their at-risk status and to facilitate predictive testing.
|
Ancillary studies
Communicate via family outreach program website
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Web-Based Family Outreach Registry
Time Frame: Continual assessment of data over participant's life time (target follow-up duration: 40 Years)
|
Data analysis for core functions of the web-based Family Outreach Registry will generally be descriptive.
Web-based program to improve the way in which genetic test results are communicated within families and to increase the number of at-risk relatives who become aware of their risks.
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Continual assessment of data over participant's life time (target follow-up duration: 40 Years)
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Selvi Thirumurthi, M.D. Anderson Cancer Center
Publications and helpful links
Helpful Links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimated)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2014-0715 (Other Identifier: M D Anderson Cancer Center)
- P30CA016672 (U.S. NIH Grant/Contract)
- NCI-2020-00567 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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