Automatic vs. Manual Optic Disc Planimetry (Planimetry)

March 24, 2020 updated by: University of Zurich

Automatic vs. Manual Optic Cup and Optic Disc Segmentation in Glaucoma

Manually and automatically by mashing learning algorithm optic disc will be evaluated (planimetry).

Study Overview

Status

Withdrawn

Conditions

Intervention / Treatment

Detailed Description

Cross-Over non-randomized Case-Series. Arm 1 (Manual segmentation): Manually marking of the boundaries of the optic disc and it's excavation on color photographs of the optic disc. Arm 2 (Automated segmentation): Automatic detection of the boundaries of the optic disc and it's excavation. Calculation of cup size, size of excavation, cup-to-disc ratio, and rim area. Comparison of all parameters of both arms and computing of agreement.

Study Type

Observational

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

patients with a diagnosis of open-angle glaucoma

Description

Inclusion Criteria:

  • open-angle glaucoma

Exclusion Criteria:

  • no fundus photography of the optic disc performed

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
patients with open angle glaucoma
patients with open angle glaucoma who had their optic discs routinely documented by fundus photography. Optic disc photographs will be analyzied by manual planimetry or automated planimetry.
Other: manual planimetry
Manually marking of the boundaries of the optic disc and it's excavation on color photographs of the optic disc.
Other: automated planimetry
Automatic detection of the boundaries of the optic disc and it's excavation on color photographs of the optic disc.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
agreement measured by kappa statistics
Time Frame: Baseline visit in the outpatient department
agreement measured by kappa statistics
Baseline visit in the outpatient department

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Cup size
Time Frame: Baseline visit in the outpatient department
Cup size
Baseline visit in the outpatient department
size of excavation
Time Frame: Baseline visit in the outpatient department
size of excavation
Baseline visit in the outpatient department
vertical cup to disc ratio
Time Frame: Baseline visit in the outpatient department
vertical cup to disc ratio
Baseline visit in the outpatient department
rim area
Time Frame: Baseline visit in the outpatient department
rim area
Baseline visit in the outpatient department

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Zurich

Collaborators

Swiss Federal Institute of Technology

Investigators

  • Principal Investigator: Jens Funk, MD, PhD, University of Zurich

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

July 1, 2017

Primary Completion (Actual)

March 20, 2020

Study Completion (Actual)

March 20, 2020

Study Registration Dates

First Submitted

April 29, 2015

First Submitted That Met QC Criteria

May 5, 2015

First Posted (Estimate)

May 8, 2015

Study Record Updates

Last Update Posted (Actual)

March 26, 2020

Last Update Submitted That Met QC Criteria

March 24, 2020

Last Verified

March 1, 2020

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Optic Disc Planimetry

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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