- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02552030
iPhone App Compared to Standard RR-measurement (iPARR)
iPhone App Compared to Standard RR-measurement - iPARR Trial
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Participants will be asked for consent at the University Hospital Basel at random based on availability. Recruitment is not limited to patients. After consenting patients will accompanied to a RR-measurement unit, positioned in a chair and kept at rest for 4 minutes. Then 7 blood pressure measurements at the same arm will be performed (Cuff/iPhone/Cuff/iPhone/Cuff/iPhone/Cuff). The Cuff measurement results will be documented in the source documents (mmHg) and transferred to a trial database. The iPhone data will be transferred with patient ID to "Preventicus" for calculation of the systolic blood pressure values (mmHg) based on the pulse waves recorded by transillumination of the index fingers of the participants. "Preventicus" will have NO access to the Cuff-measurement data. Then this data will be retransferred to the trial site and merged with help of the patient ID. Absolute and relative differences of the measured (Omron) and calculated (iPhone) systolic blood pressure values (mmHg) for will be calculated and published.
A subgroup of 40 participants will be evaluated in a highly standardized fashion according the ESH (European Society Hypertension) guidelines for validation studies. These data will then be published separately for validation purposes.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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BS
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Basel, BS, Switzerland, 4031
- Universityhospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- able to give informed consent
- in Sinus rhythm
- no anatomical limitation to take blood pressure
Exclusion Criteria:
- Atrial fibrillation
- Dialysis shunt
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Blood pressure-measurement
Seven repetitive blood pressure measurements will be performed the left or right arm of all participants with an iPhone 4s and a conventional oscillometric device 'cuff device (Omron HBP-1300-E Pro)'
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Comparison of systolic blood pressure results measured with an oscillometric cuff device (Omron HBP-1300-E Pro) and iPhone 4s
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Absolute difference between systolic blood pressure values determined with an oscillometric cuff device and an iPhone 4s (Delta mmHg)
Time Frame: 1 day
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In each participant seven repetitive blood pressure measurements will be performed.
Starting with a conventional cuff measurement followed by an iPhone measurement, followed by a conventional cuff measurement and so on.
Then the absolute difference between each pair of successive measurements will be calculated.
These differences will then be averaged and documented as primary result.
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1 day
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Relative difference between oscillometric blood pressure measurement and iPhone based blood pressure measurement
Time Frame: 1 day
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Same as primary outcome, but calculation of delta (mmHg) and documentation as relative value (%) of the absolute systolic value.
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1 day
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Percent of invalid measurements
Time Frame: 1 day
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Percent of measurements that cannot be used for analysis
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1 day
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Comparison of primary outcome in the subgroup of patients with atherosclerosis compared to the participants without arteriosclerosis.
Time Frame: 1 day
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Quantitative differences between the accuracy of the iPhone measurements in the patients with known arteriosclerosis and the patients without arteriosclerosis
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1 day
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Collaborators and Investigators
Sponsor
Collaborators
Publications and helpful links
General Publications
- Dorr M, Weber S, Birkemeyer R, Leonardi L, Winterhalder C, Raichle CJ, Brasier N, Burkard T, Eckstein J. iPhone App compared with standard blood pressure measurement -The iPARR trial. Am Heart J. 2021 Mar;233:102-108. doi: 10.1016/j.ahj.2020.12.003. Epub 2020 Dec 13.
- Vischer AS, Socrates T, Winterhalder C, Eckstein J, Mayr M, Burkard T. How should we measure blood pressure? Implications of the fourth blood pressure measurement in office blood pressure. J Clin Hypertens (Greenwich). 2021 Jan;23(1):35-43. doi: 10.1111/jch.14130. Epub 2020 Dec 14.
- Vischer AS, Mayr M, Socrates T, Winterhalder C, Leonardi L, Eckstein J, Burkard T. Impact of Single-Occasion American vs. Canadian Office Blood Pressure Measurement Recommendations on Blood Pressure Classification. Am J Hypertens. 2019 Jan 15;32(2):143-145. doi: 10.1093/ajh/hpy159.
- Raichle CJ, Eckstein J, Lapaire O, Leonardi L, Brasier N, Vischer AS, Burkard T. Performance of a Blood Pressure Smartphone App in Pregnant Women: The iPARR Trial (iPhone App Compared With Standard RR Measurement). Hypertension. 2018 Jun;71(6):1164-1169. doi: 10.1161/HYPERTENSIONAHA.117.10647. Epub 2018 Apr 9.
- Burkard T, Mayr M, Winterhalder C, Leonardi L, Eckstein J, Vischer AS. Reliability of single office blood pressure measurements. Heart. 2018 Jul;104(14):1173-1179. doi: 10.1136/heartjnl-2017-312523. Epub 2018 Mar 12.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- EKNZ 2015-287
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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