Multi-center Imaging Genetics Studies in China (CHIMGEN)

To study the impact of genetic and environmental factors on high-level cognition associated neural circuits among healthy young Chinese Han subjects.

Study Overview

• Status: Unknown
• Conditions: Schizophrenia; Alzheimer Disease; Major Depressive Disorders

Detailed Description

The investigators plan to collect behavioral assessment and environmental factors data,peripheral blood sample, MRI brain images in more than 10,000 healthy young Chinese Han individuals in order to build the pathway from gene to high-level cognitive phenotypes.

• Study Type: Observational
• Enrollment (Anticipated): 10000

Contacts and Locations

Study Locations

• China
  • Tianjin
    • Tianjin, Tianjin, China, 300052
      • Recruiting
      • Tianjin Medical University General Hospital
      • Contact: Chunshui Yu, PhD; Email: chunshuiyu@vip.163.com
      • Contact: Qiang Xu, PhD; Email: xuqiang9042@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 30 years (ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Healthy young Chinese Han subjects age 18-30

Description

Inclusion Criteria:

• aged 18-30
• Chinese Han
• right-handed
• without history of neuropsychiatric disease
• no substance addiction
• smoking

Exclusion Criteria:

• younger or elder than 18-30 year-old
• other ethnics
• with history of neuropsychiatric disease
• with history of neuropsychiatric disease among first,second and third degree relatives

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Healthy young subjects; Healthy young Chinese Han subjects aged 18-30

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Brain structure and function measured by MRI scans	The participants will receive non-interventional multi-modal MRI scans, such as 3D-T1WI, DTI, DKI, ASL, REST-fmri, then the investigators can acquire the brain volume in region of interest, such as bilateral hippocampus.	2 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Childhood adversities as assessed by Childhood Trauma Questionnaire-Short Form (Chinese Version)	To investigate impact of the adversities in early life of participants on brain structure and function as well as the interaction effect of childhood adversities and genetic variations,such as 5-HTTLPR polymorphism.	2 years

Collaborators and Investigators

• Sponsor: Tianjin Medical University General Hospital
• Collaborators: The First Affiliated Hospital with Nanjing Medical University; Xijing Hospital; The First Affiliated Hospital of Anhui Medical University; Xiangya Hospital of Central South University; Wuhan University; LanZhou University; Peking Union Medical College Hospital; Chinese PLA General Hospital; The Second Hospital of Hebei Medical University; RenJi Hospital; Huashan Hospital; Southwest Hospital, China; West China Hospital; Tongji Hospital; Qilu Hospital of Shandong University; Second Affiliated Hospital, School of Medicine, Zhejiang University; University of Electronic Science and Technology of China; First Affiliated Hospital Xi'an Jiaotong University; Xuanwu Hospital, Beijing; The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School; Beijing Tongren Hospital; Tianjin Medical University Cancer Institute and Hospital; Beijing Hospital; Xuzhou Medical University; Chinese Academy of Sciences; The First Affiliated Hospital of Zhengzhou University; Guangdong Provincial People's Hospital; The First Hospital of Jilin University; Henan Provincial People's Hospital; Second Affiliated Hospital of Wenzhou Medical University; The University of Science and Technology of China; Central South University; Tang-Du Hospital; Tianjin Medical University Second Hospital; Tianjin First Central Hospital; First Affiliated Hospital of Wenzhou Medical University; The First Affiliated Hospital of Shanxi Medical University; Beijing Normal University; First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Dalian Medical University; Yantai Yuhuangding Hospital; Guangdong No.2 Provincial People's Hospital; The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine; Nanjing PLA General Hospital; Tianjin Huanhu Hospital; Pingjin Hospital,Logistics University of Chinese People's Armed Police Forces; School of Medical Imaging, Tianjin Medical University; Inner Mongolia Medical College Hospital; The Frist Hospital Of China Medical University; Shan dong Medical Imaging Research Institute; South China Normal University、Hainan General Hospital
• Investigators: Principal Investigator: Chunshui Yu, PhD, Tianjin Medical University General Hospital

Publications and helpful links

General Publications

• Braskie MN, Jahanshad N, Stein JL, Barysheva M, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Ringman JM, Toga AW, Thompson PM. Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci. 2011 May 4;31(18):6764-70. doi: 10.1523/JNEUROSCI.5794-10.2011.
• Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993 Aug 13;261(5123):921-3. doi: 10.1126/science.8346443.

Study record dates

Study Major Dates

• Study Start: November 1, 2015
• Primary Completion (ANTICIPATED): December 1, 2019
• Study Completion (ANTICIPATED): December 1, 2020

Study Registration Dates

• First Submitted: February 7, 2016
• First Submitted That Met QC Criteria: February 11, 2016
• First Posted (ESTIMATE): February 12, 2016

Study Record Updates

• Last Update Posted (ACTUAL): April 10, 2019
• Last Update Submitted That Met QC Criteria: April 8, 2019
• Last Verified: April 1, 2019

More Information

Terms related to this study

• Keywords: Environmental factors; Genome-wide association studies; Behavioral Assessment; Pathway analysis
• Additional Relevant MeSH Terms: Mental Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Mood Disorders; Neurocognitive Disorders; Schizophrenia Spectrum and Other Psychotic Disorders; Neurodegenerative Diseases; Dementia; Tauopathies; Depressive Disorder; Schizophrenia; Alzheimer Disease; Depressive Disorder, Major
• Other Study ID Numbers: 81425013

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: The investigators plan to share the IPD with the member institutes or hospitals after the total completion of the investigation.