Quality of Pediatric Resuscitation in a Multicenter Collaborative (pediRES-Q)
September 29, 2025 updated by: Children's Hospital of Philadelphia
Quality of Pediatric Resuscitation in a Multicenter Collaborative: An Observational Study
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests.
The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.
Study Overview
Status
Recruiting
Conditions
Detailed Description
Cardiac arrests in children are a major public health problem. Thousands of children each year in the USA are treated with cardiopulmonary resuscitation (CPR) and managed after their cardiac arrest. Neurological outcomes following these in-hospital CPR events are often abnormal. As children with neurological deficits following CPR are a major burden for families and society, improving neurological outcomes through superior chest compression delivery during CPR and optimal care and management after cardiac arrest is an important clinical goal.
Therefore, the objective of this investigation is to obtain evidentiary support to associate the relationship of quantitative CPR quality data (depth, rate, chest compressions (CC) fraction, compression release) during CPR, post-cardiac arrest care (PCAC) and patient survival in those children who suffer an arrest within the study (RES-Q) Network.
Study Type
Observational
Enrollment (Estimated)
7000
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Vinay Nadkarni, MD, MS
- Phone Number: 215-590-7430
- Email: nadkarni@chop.edu
Study Contact Backup
- Name: Kathryn Graham
- Phone Number: 215-590-1859
- Email: grahamk1@chop.edu
Study Locations
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Nedlands, Australia, 6009
- Recruiting
- Perth Children's Hospital
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Contact:
- Simon Erickson
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South Brisbane, Australia, 4101
- Recruiting
- Queensland Children's Hospital
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Contact:
- Jason Acworth
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New South Wales
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Westmead, New South Wales, Australia, 2145
- Recruiting
- The Children's Hospital at Westmead
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Contact:
- Andrea Christoff
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São Paulo, Brazil, 01227-200
- Recruiting
- Sabara Hospital Infantil
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Contact:
- Nelson Horigeshi
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Calgary, Canada, AB T3B
- Recruiting
- Alberta Children's
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Contact:
- Jonathan Gilleland
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Alberta
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Edmonton, Alberta, Canada, T6G 2B7
- Recruiting
- Stollery Children's Hospital
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Contact:
- Allan DeCaen
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British Columbia
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Vancouver, British Columbia, Canada, V6H 3N1
- Recruiting
- BC Children's
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Contact:
- Srinivas Murthy
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Bogotá, Colombia
- Recruiting
- Instituto Roosevelt
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Contact:
- Luz M Meija
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Roma, Italy, 486686
- Recruiting
- IRCCS Ospedale Pediatrico Bambino Gesu
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Contact:
- Orsola Gawronski
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Aichi, Japan, 474-8710
- Recruiting
- Aichi Children's Health and Medical Center
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Contact:
- Takanari lkeyama
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Kobe, Japan, 650-0047
- Recruiting
- Kobe Children's Hospital (Hyogo Prefectural)
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Contact:
- Hiro Kurosawa
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Tokyo, Japan, 183-8561
- Recruiting
- Tokyo Metropolitan Children's Medical Center
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Contact:
- Kazuhiro Shoya
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Rotterdam, Netherlands, 3015
- Recruiting
- Erasmus MC - Sophia Children's
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Contact:
- Corinne Buysse
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Auckland, New Zealand, 1023
- Recruiting
- Starship Children's Hospital
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Contact:
- Gabrielle Nuthall
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Singapore, Singapore, 119074
- Recruiting
- National University Hospital
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Contact:
- Jacqueline Ong
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Singapore, Singapore, 229899
- Recruiting
- KK Women's & Children's Hospital
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Contact:
- Gene Ong
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Seongnam, South Korea, 13620
- Recruiting
- Seoul National University Bundang Hospital
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Contact:
- Dongbum Suh
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Madrid, Spain, 46 28007
- Recruiting
- Gregorio Marañón General University Hospital
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Contact:
- Jesus Lopez-Herce
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Taipei, Taiwan, 100229
- Recruiting
- National Taiwan University Hospital
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Contact:
- Shu-Chen Huang
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Bangkok, Thailand, 10330
- Recruiting
- King Chulalongkorn University
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Contact:
- Rujipat Samransamruajkit
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London, United Kingdom, WC1N 3JH
- Recruiting
- Great Ormond Street Hospital
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Contact:
- Sophie Skelett
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California
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Los Angeles, California, United States, 90048
- Recruiting
- Cedars-Sinai Medical Center
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Contact:
- Dipti Padhya, MD
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Los Angeles, California, United States, 90027
- Recruiting
- Kaiser Permanente
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Contact:
- Gim H Tan
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Madera, California, United States, 93636
- Recruiting
- Valley Children's Hospital
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Contact:
- Tara Lemoine
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Orange, California, United States, 92868
- Recruiting
- Chldren's Hospital of Orange County
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Contact:
- Jennifer Hayes
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Palo Alto, California, United States, 94304
- Recruiting
- Stanford University
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Contact:
- Marc Berg
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San Diego, California, United States, 92123
- Recruiting
- Rady Children's Hospital
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Contact:
- Helen Harvey
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Colorado
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Aurora, Colorado, United States, 80045
- Recruiting
- Children's Colorado
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Contact:
- Kimberly DiMaria
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Delaware
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Wilmington, Delaware, United States, 19803
- Recruiting
- Nemours Children's Hospital
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Contact:
- Yosef Levenbrown
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Florida
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St. Petersburg, Florida, United States, 33701
- Not yet recruiting
- All Children's Hospital
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Contact:
- Ladonna Bingham, MD
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Georgia
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Atlanta, Georgia, United States, 30322
- Recruiting
- Children's Healthcare of Atlanta (CHOA)
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Contact:
- Prakadeshwari Rajapreyar
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Illinois
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Chicago, Illinois, United States, 60637
- Recruiting
- University of Chicago, Comer Children's Hospital
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Contact:
- Priti Jani
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Chicago, Illinois, United States, 60611
- Recruiting
- Lurie Children's (Children's Hospital of Chicago)
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Contact:
- Candace Mannarino
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Indiana
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Indianapolis, Indiana, United States, 46202
- Recruiting
- Riley Hospital for Children
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Contact:
- Kamal Abulebda
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Iowa
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Iowa City, Iowa, United States, 52242
- Recruiting
- University of Iowa Stead Family Children's Hospital
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Contact:
- Sarah Haskell
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Kentucky
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Lexington, Kentucky, United States, 40536
- Recruiting
- Kentucky Children's Hospital
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Contact:
- Rhea Vidrine
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Maryland
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Baltimore, Maryland, United States, 21287
- Recruiting
- The Johns Hopkins Hospital
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Contact:
- Elizabeth Hunt
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Massachusetts
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Boston, Massachusetts, United States, 02114
- Recruiting
- Massachusetts General Hospital
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Contact:
- Michael Flaherty
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Boston, Massachusetts, United States, 02115
- Recruiting
- Boston Children's
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Contact:
- Monica Kleinmann
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Missouri
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St Louis, Missouri, United States, 63110
- Recruiting
- St. Louis Children's Hospital
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Contact:
- Stuart Friess
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Nebraska
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Omaha, Nebraska, United States
- Recruiting
- Nebraska Medical Center
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Contact:
- Laura Ortmann
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New Hampshire
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Lebanon, New Hampshire, United States, 03756
- Recruiting
- Dartmouth Hitchcock Medical Center
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Contact:
- Kelly Corbett
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New York
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Albany, New York, United States, 12208
- Recruiting
- Albany Medical Center
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Contact:
- Ilana Harwayne-Gidansky, MD
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New York, New York, United States, 10032
- Recruiting
- Morgan Stanley Children's Hospital
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Contact:
- Anita Sen
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New York, New York, United States, 10029
- Recruiting
- Mount Sinai Kravis Children's Hospital
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Contact:
- Sandeep Gangadharam
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Queens, New York, United States, 11040
- Recruiting
- Cohen Children's Medical Center
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Contact:
- Todd Sweberg
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Stony Brook, New York, United States, 11794
- Recruiting
- Stony Brook University Hospital
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Contact:
- Ilana Harwayne-Gidansky
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Syracuse, New York, United States, 13210
- Recruiting
- Upstate Golisano Children's Hospital
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Contact:
- Angela Wratney
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North Carolina
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Chapel Hill, North Carolina, United States, 27514
- Recruiting
- University of North Carolina
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Contact:
- Afsaneh Pirzadeh
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Ohio
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Akron, Ohio, United States, 44308
- Recruiting
- Akron Children's
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Contact:
- Claire Hanson, MD
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Cincinnati, Ohio, United States, 45229
- Recruiting
- Cincinnati Children's Hospital Medical Center
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Contact:
- Maya Dewan
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Columbus, Ohio, United States, 43205
- Recruiting
- Nationwide Children's Hospital
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Contact:
- Tensing Maa
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Pennsylvania
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Philadelphia, Pennsylvania, United States, 19104
- Recruiting
- Children's Hospital of Philadelphia
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Contact:
- Vinay Nadkarni, MD, MS
- Phone Number: 215-590-7430
- Email: nadkarni@chop.edu
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South Carolina
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Charleston, South Carolina, United States
- Not yet recruiting
- Medical University of South Carolina
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Contact:
- Allison Whalen, MD
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Texas
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Austin, Texas, United States, 78723
- Recruiting
- Dell Children's Medical Center
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Contact:
- Daniel Stromberg, MD
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Dallas, Texas, United States, 75390
- Recruiting
- University of Texas Southwestern
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Contact:
- Priscilla Yu, MD
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Dallas, Texas, United States, 75230
- Recruiting
- Medical City Children's Hospital
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Contact:
- Tia Raymond
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San Antonio, Texas, United States, 78207
- Recruiting
- The Children's Hospital of San Antonio
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Contact:
- Utpal Bhalala
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Virginia
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Richmond, Virginia, United States, 23219
- Recruiting
- Children's Hospital of Richmond at VCU
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Contact:
- Michelle Olson, MD
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Washington
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Seattle, Washington, United States, 98105
- Recruiting
- Seattle Children's Hospital
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Contact:
- Joan Roberts
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Wisconsin
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Milwaukee, Wisconsin, United States, 53226
- Recruiting
- Medical College of Wisconsin
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Contact:
- Andrea Maxwell
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
1 second to 17 years (Child, Adult)
Accepts Healthy Volunteers
No
Sampling Method
Non-Probability Sample
Study Population
Data will be collected from pediatric cardiac arrest events as part of standard clinical operations.
Description
Inclusion Criteria:
- Patient received chest compressions for at least 1 minute
- Patient between gestational age ≥37 weeks and 18 years of age
Exclusion Criteria:
- Patient on veno-arterial extracorporeal membrane oxygenation (ECMO) therapy at beginning of CPR event
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
|---|
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Pediatric Cardiac Arrests
Pediatric cardiac arrests requiring chest compressions for at least 1 minute managed at clinical centers identified as part of standard clinical operations.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
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Aggregate score composed of American Heart Association (AHA) recommended depth, rate, and chest compression fraction during CPR
Time Frame: 10 Years
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Primary outcome: "Guideline-compliant CPR" which will be determined by an aggregate score comprised of the following three components: depth, rate, and chest compression fraction.
The three components will be analyzed in 30 and 60 second epochs.
"Guideline-compliant CPR" requires that each component meet the following criteria: 1) Age-determined American Heart Association (AHA) guideline recommended depth; 2) rate ≥ 90 and ≤ 120 CC/min; and 3) CC Fraction ≥ 0.80.
Depth, rate, and CC Fraction will be calculated for each epoch and an aggregate score will be assigned.
The primary analysis will be performed on that total score.
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10 Years
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Principal Investigator: Vinay Nadkarni, MD, MS, Children's Hospital of Philadelphia
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Niles DE, Duval-Arnould J, Skellett S, Knight L, Su F, Raymond TT, Sweberg T, Sen AI, Atkins DL, Friess SH, de Caen AR, Kurosawa H, Sutton RM, Wolfe H, Berg RA, Silver A, Hunt EA, Nadkarni VM; pediatric Resuscitation Quality (pediRES-Q) Collaborative Investigators. Characterization of Pediatric In-Hospital Cardiopulmonary Resuscitation Quality Metrics Across an International Resuscitation Collaborative. Pediatr Crit Care Med. 2018 May;19(5):421-432. doi: 10.1097/PCC.0000000000001520.
- Sweberg T, Sen AI, Mullan PC, Cheng A, Knight L, Del Castillo J, Ikeyama T, Seshadri R, Hazinski MF, Raymond T, Niles DE, Nadkarni V, Wolfe H; pediatric resuscitation quality (pediRES-Q) collaborative investigators. Description of hot debriefings after in-hospital cardiac arrests in an international pediatric quality improvement collaborative. Resuscitation. 2018 Jul;128:181-187. doi: 10.1016/j.resuscitation.2018.05.015. Epub 2018 May 26.
- Pfeiffer S, Lauridsen KG, Wenger J, Hunt EA, Haskell S, Atkins DL, Duval-Arnould JM, Knight LJ, Cheng A, Gilfoyle E, Su F, Balikai S, Skellett S, Hui MY, Niles DE, Roberts JS, Nadkarni VM, Tegtmeyer K, Dewan M; Pediatric Resuscitation Quality Collaborative Investigators. Code Team Structure and Training in the Pediatric Resuscitation Quality International Collaborative. Pediatr Emerg Care. 2021 Aug 1;37(8):e431-e435. doi: 10.1097/PEC.0000000000001748.
- Esangbedo I, Yu P, Raymond T, Niles DE, Hanna R, Zhang X, Wolfe H, Griffis H, Nadkarni V; Pediatric Resuscitation Quality (pediRES-Q) Collaborative Investigators. Pediatric in-hospital CPR quality at night and on weekends. Resuscitation. 2020 Jan 1;146:56-63. doi: 10.1016/j.resuscitation.2019.10.039. Epub 2019 Nov 14.
- Wolfe HA, Wenger J, Sutton R, Seshadri R, Niles DE, Nadkarni V, Duval-Arnould J, Sen AI, Cheng A. Cold Debriefings after In-hospital Cardiac Arrest in an International Pediatric Resuscitation Quality Improvement Collaborative. Pediatr Qual Saf. 2020 Jul 8;5(4):e319. doi: 10.1097/pq9.0000000000000319. eCollection 2020 Jul-Aug.
- Raymond TT, Pandit SV, Griffis H, Zhang X, Hanna R, Niles DE, Silver A, Lasa JJ, Haskell SE, Atkins DL, Nadkarni VM; Pediatric Resuscitation Quality Collaborative (pediRES-Q) Investigators. Effect of Amplitude Spectral Area on Termination of Fibrillation and Outcomes in Pediatric Cardiac Arrest. J Am Heart Assoc. 2021 Jun 15;10(12):e020353. doi: 10.1161/JAHA.120.020353. Epub 2021 Jun 5.
- Raymond TT, Esangbedo ID, Rajapreyar P, Je S, Zhang X, Griffis HM, Wakeham MK, Petersen TL, Kirschen MP, Topjian AA, Lasa JJ, Francoeur CI, Nadkarni VM; pediatric Resuscitation Quality (pediRES-Q) Collaborative Investigators. Cerebral Oximetry During Pediatric In-Hospital Cardiac Arrest: A Multicenter Study of Survival and Neurologic Outcome. Crit Care Med. 2024 May 1;52(5):775-785. doi: 10.1097/CCM.0000000000006186. Epub 2024 Jan 5.
- Ong GY, Chen ZJ, Niles DE, Srinivasan V, Sen AI, Skellett S, Ikeyama T, Del Castillo J, Berg RA, Nadkarni VM. Poor Concordance of One-Third Anterior-Posterior Chest Diameter Measurements With Absolute Age-Specific Chest Compression Depth Targets in Pediatric Cardiac Arrest Patients. J Am Heart Assoc. 2023 Jul 18;12(14):e028418. doi: 10.1161/JAHA.122.028418. Epub 2023 Jul 8.
- Gray JM, Raymond TT, Atkins DL, Tegtmeyer K, Niles DE, Nadkarni VM, Pandit SV, Dewan M; pediRES-Q Investigators. Inappropriate Shock Delivery Is Common During Pediatric In-Hospital Cardiac Arrest. Pediatr Crit Care Med. 2023 Aug 1;24(8):e390-e396. doi: 10.1097/PCC.0000000000003241. Epub 2023 Apr 28.
Helpful Links
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
May 2, 2016
Primary Completion (Estimated)
January 1, 2030
Study Completion (Estimated)
January 1, 2030
Study Registration Dates
First Submitted
January 28, 2016
First Submitted That Met QC Criteria
March 9, 2016
First Posted (Estimated)
March 15, 2016
Study Record Updates
Last Update Posted (Estimated)
October 2, 2025
Last Update Submitted That Met QC Criteria
September 29, 2025
Last Verified
September 1, 2025
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 15-012099
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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