Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.

December 3, 2018 updated by: St. Olavs Hospital

Effects of Aerobic Exercise Intensity on Affective States and Brain Derived Neurotropic Factor in Patients With Depression

Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits. The magnitude of the increase of serum BDNF might be exercise intensity dependent, but no study has compared low high-aerobic-intensity training at 90-95 % of the maximal heart rate (HRmax) with long-slow-distance training at 70 % of the HRmax in patients with depression.

The aim of this study is to compare changes in serum BDNF levels after high-aerobic-intensity training and long-slow-distance training in a intra-individual design in patients suffering from depression. The results will give indications of a possible difference in BDNF response between aerobic intensities and may be uses as pilot data for calculating sample size.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

21

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Norway
      • Trondheim, Norway
        • St.Olavs university Hospital, Departement of Østmarka

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

14 years to 61 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Moderate or severe depression (ICD10: F32-F33)

Exclusion Criteria:

  • Bipolar disorder.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Exercise
Acute High aerobic intensity training (HIT) and long slow distance training (LSD)
Behavioral: High aerobic intensity training (HIT)
One training session, high aerobic intensity training (HIT) at 90-95 % of the maximal heart rate (HRmax)
Behavioral: Long slow distance training (LSD)
One training session, long slow distance training (LSD) at 70 % of the HRmax

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in serum brain derived neurotropic factor (BDNF)
Time Frame: 15 minutes before exercise to 5> minutes after exercise.
To measure serum BDNF levels, blood samples will be taken before and after each workout session.
15 minutes before exercise to 5> minutes after exercise.

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in affective symptoms
Time Frame: 15 minutes before exercise to 15> minutes after exercise.
The positive and negative affect schedule (PANAS) .
15 minutes before exercise to 15> minutes after exercise.
Change in state of anxiety.
Time Frame: 15 minutes before exercise and 15> minutes after exercise.
A short form of state trait anxiety inventory for adults (STAI) is used to detect their state of anxiety.
15 minutes before exercise and 15> minutes after exercise.
Change in subjective exercise experience
Time Frame: 15 minutes before exercise to 15> minutes after exercise.
The Subjective exercise experience scale (SEES).
15 minutes before exercise to 15> minutes after exercise.
Maximal oxygen uptake
Time Frame: Baseline
Baseline
Maximal Heart rate
Time Frame: Baseline
Baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

St. Olavs Hospital

Collaborators

Norwegian University of Science and Technology

Investigators

  • Study Director: Pål Sandvik, MD, St.Olavs University Hospital, Østmarka

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 1, 2016

Primary Completion (Actual)

December 1, 2016

Study Completion (Actual)

December 1, 2016

Study Registration Dates

First Submitted

March 15, 2016

First Submitted That Met QC Criteria

April 13, 2016

First Posted (Estimate)

April 18, 2016

Study Record Updates

Last Update Posted (Actual)

December 4, 2018

Last Update Submitted That Met QC Criteria

December 3, 2018

Last Verified

December 1, 2018

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2015/2230

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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