Turkish Thoracic Society Usual Interstitial Pneumonia Registry Study (TURK-UIP)

The Turkish Thoracic Society Usual Interstitial Pneumonia Registry (TURK-UIP) is a collaborative project to coordinate a team of investigators from various regions of Turkey. The purpose of the Registry is to collect epidemiological data on patients with idiopathic pulmonary fibrosis and other causes of UIP, and to obtain information about the natural course of the disease and the treatment response.

Study Overview

• Status: Terminated
• Conditions: Idiopathic Pulmonary Fibrosis; Usual Interstitial Pneumonia

Detailed Description

The TURK-UIP Registry is a web based application that will store information about patients. A HRCT pattern consistent with UIP will be confirmed by 3 radiologists. At the 3-month visits, the pulmonary function tests and the 6-minute walk test will be recorded. Patients will be prospectively followed for a 5-year period.

• Study Type: Observational
• Enrollment (Actual): 1678

Contacts and Locations

Study Locations

• Turkey
  • Adana, Turkey
    • Cukurova University Medical Faculty
  • Adapazari, Turkey
    • Sakarya University Faculty of Medicine
  • Ankara, Turkey, MD
    • Gazi University Medical Faculty
  • Ankara, Turkey
    • Ankara University Faculty of Medicine
  • Ankara, Turkey
    • Ankara University Medical Faculty
  • Ankara, Turkey
    • Ataturk Chest Diseases and Chest Surgery Education and Research Hospital
  • Ankara, Turkey
    • Atatürk Chest Disease and Chest Surgery Research and Training Hospital
  • Ankara, Turkey
    • Dışkapı Yıldırım Beyazıt training and research hospital
  • Ankara, Turkey
    • Gazi University Medical Faculty
  • Antalya, Turkey
    • Akdeniz University Medical Faculty
  • Aydin, Turkey
    • Adnan Menderes University Faculty of Medicine
  • Bursa, Turkey
    • Uludag University Medical Faculty
  • Denizli, Turkey
    • Pamukkale University Medical Faculty
  • Diyarbakir, Turkey
    • Dicle University Medical Faculty
  • Diyarbakir, Turkey
    • Memorial Diyarbakir Hospital
  • Duzce, Turkey
    • Duzce University Medical Faculty
  • Edirne, Turkey
    • Trakya University Faculty of Medicine
  • Erzurum, Turkey
    • ATATURK UNIVERSITY FACULTY OF MEDICINE
  • Erzurum, Turkey
    • Ataturk University Medical Faculty
  • Istanbul, Turkey
    • Dr.Lutfi Kirdar Kartal Education and Research Hospital
  • Istanbul, Turkey
    • Istanbul University Cerrahpasa Medical Faculty
  • Istanbul, Turkey
    • Istanbul University Istanbul Medical Faculty
  • Istanbul, Turkey
    • Istanbul University, Istanbul Medical Faculty
  • Istanbul, Turkey
    • Koç University Medical Faculty
  • Istanbul, Turkey
    • Sisli Florence Nightingale Hospital
  • Istanbul, Turkey
    • Sureyyapasa Chest Diseases and Thoracic Surgery Education and Research Hospital
  • Istanbul, Turkey
    • Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital
  • Istanbul, Turkey
    • Süreyyapasa Pulmonary Diseases and Thoracic Surgery Education and Research Hospital
  • Istanbul, Turkey
    • Yedikule Chest Disease Education and Research Hospital
  • Istanbul, Turkey
    • Yedikule Chest Diseases and Chest Surgery Education and Research Hospital
  • Istanbul, Turkey
    • Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital
  • Istanbul, Turkey
    • Yedikule Chest Diseases Education and Research Hospital
  • Istanbul, Turkey
    • Yedikule Hospital for Chest Disease and Chest Surgery
  • Istanbul, Turkey
    • Yedikule Hospital for Chest Disease and Thoracic Surgery
  • Istanbul, Turkey
    • Yedikule Pulmonary Diseases Education and Research Hospital
  • Izmir, Turkey
    • Dokuz Eylul University Medical Faculty
  • Izmir, Turkey
    • Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital
  • Izmir, Turkey
    • Dr. Suat Seren Pulmonary Diseases and Thoracic Surgery Training and Research Hospital
  • Izmir, Turkey
    • Ege University Faculty of Medicine
  • Izmir, Turkey
    • Ege University Medical Faculty
  • Kirikkale, Turkey
    • Kirikkale University Medical Faculty
  • Kocaeli, Turkey
    • Kocaeli University Faculty of Medicine
  • Kocaeli, Turkey
    • Kocaeli University Medical Faculty
  • Konya, Turkey
    • Necmettin Erbakan University Meram Medical Faculty
  • Samsun, Turkey
    • Ondokuz Mayis University Medical Faculty
  • Trabzon, Turkey
    • Karadeniz Technical University Medical Faculty

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Subjects diagnosed with IPF and other causes of UIP.

Description

Inclusion Criteria:

1. Understand and sign the informed consent document.
2. The presence of a definite or possible UIP pattern on high resolution computed tomography (HRCT) or a histologic UIP pattern (definite, probable and possible) on surgical lung biopsy (as defined by ATS/ERS/JRS/ALAT criteria).

Exclusion Criteria:

1. HRCT findings inconsistent with UIP pattern (peribronchovascular predominance, extensive ground glass abnormality,profuse micronodules, discrete cysts , consolidation in bronchopulmonary segment(s)/lobe(s), diffuse mosaic attenuation/air-trapping),
2. Histopathological findings inconsistent with UIP pattern (as defined by ATS/ERS/JRS/ALAT criteria).

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of subjects enrolled with IPF and other causes of UIP	Natural history of course of disease in patients with IPF and other causes of UIP.	5 years

Collaborators and Investigators

• Sponsor: Turkish Thoracic Society
• Investigators: Principal Investigator: Benan Müsellim, MD, Istanbul University,Cerrahpasa Medical Faculty, Istanbul, Turkey.

Publications and helpful links

General Publications

• Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, Lynch DA, Ryu JH, Swigris JJ, Wells AU, Ancochea J, Bouros D, Carvalho C, Costabel U, Ebina M, Hansell DM, Johkoh T, Kim DS, King TE Jr, Kondoh Y, Myers J, Muller NL, Nicholson AG, Richeldi L, Selman M, Dudden RF, Griss BS, Protzko SL, Schunemann HJ; ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011 Mar 15;183(6):788-824. doi: 10.1164/rccm.2009-040GL.
• American Thoracic Society; European Respiratory Society. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med. 2002 Jan 15;165(2):277-304. doi: 10.1164/ajrccm.165.2.ats01. No abstract available. Erratum In: Am J Respir Crit Care Med2002 Aug 1;166(3):426.
• Ryerson CJ, Corte TJ, Collard HR, Richeldi L. A global registry for idiopathic pulmonary fibrosis: the time is now. Eur Respir J. 2014 Aug;44(2):273-6. doi: 10.1183/09031936.00051914. No abstract available.

Study record dates

Study Major Dates

• Study Start: June 1, 2016
• Primary Completion (Actual): July 8, 2019
• Study Completion (Actual): July 8, 2019

Study Registration Dates

• First Submitted: June 29, 2016
• First Submitted That Met QC Criteria: June 30, 2016
• First Posted (Estimate): July 1, 2016

Study Record Updates

• Last Update Posted (Actual): September 25, 2019
• Last Update Submitted That Met QC Criteria: September 23, 2019
• Last Verified: September 1, 2019

More Information

Terms related to this study

• Keywords: Idiopathic Pulmonary Fibrosis, Usual Interstitial Pneumonia
• Additional Relevant MeSH Terms: Pathologic Processes; Infections; Respiratory Tract Infections; Respiratory Tract Diseases; Lung Diseases; Fibrosis; Pneumonia; Pulmonary Fibrosis; Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial
• Other Study ID Numbers: TTS-01

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No