Pronostic Value of Endothelial Dysfunction in Heart Failure (Pro-ICARD)

August 4, 2016 updated by: Centre Hospitalier Universitaire de Besancon
The main objective is to evaluate the pronostic value of endothelial dysfonction in acute heart failure on a combined criteria associating cardiovascular mortality, nex hospitalisation for decompensated heart failure, cardiac graft or ventricular assistance 2 month and 1 year before acute heart failure.

Study Overview

Status

Terminated

Conditions

Study Type

Observational

Enrollment (Actual)

7

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 81 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Patients with more than 18 years and less than 81 years, hospitalized for acute heart failure with left ventricular impairment (LVEF < 45%)

Description

Inclusion Criteria:

  • patients hospitalized for acute heart fialure with Left Ventricular Ejection Fraction (LVEF) < 45 % on echocardiography

Exclusion Criteria:

  • Informed consent form not signed
  • Cardiogenic, septic or hemorragic shock
  • Acute coronary syndrom with elevated troponin
  • valvular surgery or aorto-coronary graft during next 3 months
  • Cancer
  • Pregnancy
  • life expectancy over than 1 year
  • chronic renal impairment

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
mortality
Time Frame: 6 months
6 months
MR Proadrenomedulline
Time Frame: 6 months
6 months
catecholamins
Time Frame: 6 months
6 months
Time Frame: 6 months
6 months
late endothelial progenitors
Time Frame: 6 months
6 months
Peripheral tissular perfusion
Time Frame: 6 months
Near infra-red spectroscopy
6 months
hospitalisation
Time Frame: 6 months
6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Hospitalier Universitaire de Besancon

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2012

Primary Completion (Actual)

March 1, 2016

Study Completion (Actual)

March 1, 2016

Study Registration Dates

First Submitted

August 2, 2016

First Submitted That Met QC Criteria

August 4, 2016

First Posted (Estimate)

August 9, 2016

Study Record Updates

Last Update Posted (Estimate)

August 9, 2016

Last Update Submitted That Met QC Criteria

August 4, 2016

Last Verified

August 1, 2016

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • P/2012/140

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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