The Association Between Autoimmune or Inflammation and Thyroid Disease

January 4, 2020 updated by: Taichung Veterans General Hospital

The Relationship of Vascular Cell Adhesion Molecule 1, C-reactive Protein, Brain-derived Neurotrophic Factor, Orexin and Depressive Symptoms in the Subjects With Thyroid Disease

This study aims to evaluate the effects of thyroid functions on energy homeostasis and inflammation.

Study Overview

Status

Recruiting

Conditions

Detailed Description

The subjects were enrolled for evaluation of thyroid functions. The associations between thyroid function and energy homeostasis and inflammation will be assessed.

Study Type

Observational

Enrollment (Anticipated)

500

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Taiwan
      • Taichang, Taiwan, 407
        • Recruiting
        • Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital
        • Contact:
        • Contact:
        • Sub-Investigator:
          • I-Te Lee, MD
        • Principal Investigator:
          • Wayne HH Sheu, MD, PhD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Subjects with a suspicion of thyroid disease.

Description

Inclusion Criteria:

  • Subjects visits outpatient department due to a suspicion of thyroid disease

Exclusion Criteria:

  • Psychological disorders, severe inflammatory or infection diseases.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
brain-derived neurotrophic factor
Time Frame: 3 months
BDNF
3 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
vascular cell adhesion molecule 1 (VCAM-1)
Time Frame: 3 months
Inflammation
3 months
C-reactive protein (CRP)
Time Frame: 3 months
Inflammation
3 months
Orexin
Time Frame: 3 month
Psychological assessment
3 month
Zung Self-Rating Depression Scale (Zung SDS)
Time Frame: 3 month
Depressive symptom
3 month
Body composition
Time Frame: 3 month
fat component
3 month
ankle brachial index (ABI)
Time Frame: 3 months
Arterial stiffness
3 months
pulse wave velocity (PWV)
Time Frame: 3 months
Arterial stiffness
3 months
mean arterial pressure (MAP)
Time Frame: 3 months
Arterial stiffness
3 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Taichung Veterans General Hospital

Investigators

  • Principal Investigator: I-Te Lee, MD, Taichung Veterans General Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

November 1, 2011

Primary Completion (Anticipated)

December 1, 2020

Study Completion (Anticipated)

December 1, 2024

Study Registration Dates

First Submitted

September 2, 2015

First Submitted That Met QC Criteria

August 26, 2016

First Posted (Estimate)

September 1, 2016

Study Record Updates

Last Update Posted (Actual)

January 7, 2020

Last Update Submitted That Met QC Criteria

January 4, 2020

Last Verified

January 1, 2020

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CE11307

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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