- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02912546
Cerebral Perfusion Associated With Postural Changes: an ASL MR Perfusion Study (PerfIRMAVC)
Évaluation en IRM (séquence ASL) de la Variation de Perfusion cérébrale liée à la Position Corporelle.
Study Overview
Detailed Description
Material and methods:
Eighteen stroke patients, eighteen hypertensive patients and eighteen healthy subjects (men and women) will be enrolled. The investigator will use a 1.5 Tesla MRI device with a large magnet bore (70 cm) allowing positions change. Two measures will be performed, one in supine position and the other in head down position (-20°). A 3D FSE ASL sequence will be acquired and Cerebral Blood Flow (CBF) maps will be reconstructed. Volume of interest (VOI) will be placed on cortical grey matter (frontal and posterior gyrus), on subcortical deep grey matter (caudate nuclei, thalami) and subcortical white matter (semi oval centers). Differences in CBF values (in mL/100g/min) will be analyzed using SAS 9.3 software for Windows (SAS Institute, Cary North Carolina, USA).
Expected results and hypothesis:
CBF is expected to significantly vary between the supine and head down positions. It is expected to at least increase in the head down position, for stroke patients. For healthy subjects and hypertensive patients, cerebral autoregulation may limit CBF increase although an increasing trend for CBF is expected.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
-
Fort-de-France, Martinique, 97261
- Centre Hospitalier Universitaire de Martinique
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
Group of stroke patients:
- Patients between 40 and 70 years old, male or female
- With supratentorial ischemia in subacute phase (> H24)
- Patients with a recent ischemic stroke with an intracranial hemodynamic unstable and kept lying with head down of about 30
- Patient given free and informed consent to participate in research or a family representative
- Patient insured under the French social security system
- Control Group:
1- Group of patients with Hypertension.
- Patients between 40 and 70 years old, matched for age and sex to stroke patients.
- With a hypertension diagnosed since 10 years old.
Hypertension defined as three recommendations (OMS 1999, ANAES 1997 JNC VI): blood pressure 140 and / or 90 mmHg found at several consultations.
2- Group with healthy people.
- Healthy person between 30 and 70 years old, women and men. Healthy character will be defined on the basis of a physical examination (measurement of heart rate and blood pressure ) and an examination to determine the absence of endocrine pathology ... ) and the absence of drug outlet continuous.
- Person insured under the French social security system.
- Person who given free and informed his consent to participate in research or a family representative.
- Person who are not participating in another clinical study.
Exclusion Criteria:
- Patients aged under 40 years and 71 years and older for patients in groups of stroke patients and patients with hypertension
- Person under 30 years and 71 years and older for healthy people
- Person who refuses or family the participation in the study
- Person with heart antecedent or spinal disease
- Contraindications to the realization of a MRI (pacemaker, claustrophobia, metallic body may be mobilized).
- Person not insured under the French social security system,
- Pregnant women
- Persons under guardianship or curatorship
- Persons deprived of liberty by a judicial or administrative decision
- Persons who are participating in another clinical study
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Other
- Allocation: Non-Randomized
- Interventional Model: Factorial Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Control group
Eighteen healthy subjects and eighteen hypertensive patients (men and women) will be enrolled.
A 1.5 Tesla MRI device with a large magnet bore (70 cm) will be used, allowing positions change.
Two measures will be performed, one in supine position and the other in head down position (-20°).
A 3D FSE ASL sequence will be acquired and Cerebral Blood Flow (CBF) maps will be reconstructed.
Volume of interest (VOI) will be placed on cortical grey matter (frontal and posterior gyrus), on subcortical deep grey matter (caudate nuclei, thalami) and subcortical white matter (semi oval centers).
Differences in CBF values (in mL/100g/min) will be analyzed using SAS 9.3 software for Windows (SAS Institute, Cary North Carolina, USA).
|
A 1.5 Tesla MRI device with a large magnet bore (70 cm) allowing positions change will be used.
Two measures will be performed, one in supine position and the other in head down position (-20°).
A 3D FSE ASL sequence will be acquired and CBF maps reconstructed.
Volume of interest (VOI) will be placed on cortical grey matter (frontal and posterior gyrus), on subcortical deep grey matter (caudate nuclei, thalami) and subcortical white matter (semi oval centers
|
Active Comparator: Stroke patients
Eighteen stroke patients (men and women) will be enrolled.
A 1.5 Tesla MRI device with a large magnet bore (70 cm) will be used, allowing positions change.
Two measures will be performed, one in supine position and the other in head down position (-20°).
A 3D FSE ASL sequence will be acquired and Cerebral Blood Flow (CBF) maps will be reconstructed.
Volume of interest (VOI) will be placed on cortical grey matter (frontal and posterior gyrus), on subcortical deep grey matter (caudate nuclei, thalami) and subcortical white matter (semi oval centers).
Differences in CBF values (in mL/100g/min) will be analyzed using SAS 9.3 software for Windows (SAS Institute, Cary North Carolina, USA).
|
A 1.5 Tesla MRI device with a large magnet bore (70 cm) allowing positions change will be used.
Two measures will be performed, one in supine position and the other in head down position (-20°).
A 3D FSE ASL sequence will be acquired and CBF maps reconstructed.
Volume of interest (VOI) will be placed on cortical grey matter (frontal and posterior gyrus), on subcortical deep grey matter (caudate nuclei, thalami) and subcortical white matter (semi oval centers
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The change in the value of the cerebral blood flow
Time Frame: up to 1 year
|
The endpoint is the change in the value of the cerebral blood flow ( ml / 100g / min) depending on the switching position ( 0 ° and -20 °). This development will be assessed in different brain regions . In particular, it will be searched in excess of a threshold of significance . This will be accomplished independently by two experienced readers (knowing that the variation between and within road has been assessed) . If a significant difference between the two players, it will be made a consensual common measure. |
up to 1 year
|
Collaborators and Investigators
Investigators
- Principal Investigator: Mehdi MM MEJDOUBI, PhD, CHU de Fort de France
Publications and helpful links
General Publications
- Chalela JA, Alsop DC, Gonzalez-Atavales JB, Maldjian JA, Kasner SE, Detre JA. Magnetic resonance perfusion imaging in acute ischemic stroke using continuous arterial spin labeling. Stroke. 2000 Mar;31(3):680-7. doi: 10.1161/01.str.31.3.680.
- Lovell AT, Marshall AC, Elwell CE, Smith M, Goldstone JC. Changes in cerebral blood volume with changes in position in awake and anesthetized subjects. Anesth Analg. 2000 Feb;90(2):372-6. doi: 10.1097/00000539-200002000-00025.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 16/B/03
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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