- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02960672
Sequential Changes of Serum KL-6 Predict Progression in Interstitial Lung Disease
Study Overview
Status
Conditions
Detailed Description
The median follow-up period was 12 months, each patient received 4 or 5 follow-ups in our center, 336 person-times in study enrollment totally. The patients with interstitial lung disease had significantly higher serum baseline KL-6 and MMP-7 levels compared with healthy control.They divided into progressive group and non-progressive group according to disease change. Serum KL-6 and MMP-7 levels were elevated in patients if disease progression, but baseline level of biomarkers in progressive group were not significant higher compare with non-progressive group .Binary logistic regression showed △KL-6 and △MMP-7 were significant predictors for disease progression. Multivariate Cox analysis showed KL-6 and MMP-7 were significantly associated with survival along with other variables.
The serum levels of KL-6 and MMP-7 were elevated in the individuals with interstitial lung disease compared with healthy controls. The rate of poor prognosis and mortality more associated with the variability increased biomarker concentrations,rather than the baseline concentration.Therefore,Serial measurements of biomarkers contribute to the disease monitoring in clinical management.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Guangdong
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Guanzhou, Guangdong, China, 510000
- Ying Jiang
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteriar:
- Clinical diagnosis of interstitial lung disease
Exclusion Criteria:
- Diagnosise of interstitial lung disease acute excerbation
- Combined pulmonary embolism, pulmonary edema, pulmonary tuberculosis, and peumonias
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Sequential Changes of Serum KL-6 Predict Progression in Interstitial Lung Disease
Time Frame: 3 years
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Serum samples were prospectively collected from 70 patients including baseline, 1 month, 2 months, 6 months and 12 months, which were tested for a panel of Krebs van den Lungen-6 antigen (KL-6), by latex agglutination test.We have demonstrated that an increase in serum KL-6 levels, but not the level at any one point in time, predicts poor prognosis.
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3 years
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Sequential Changes of Serum MMP-7 Predict Progression in Interstitial Lung Disease
Time Frame: 3 years
|
Serum samples were prospectively collected from 70 patients including baseline, 1 month, 2 months, 6 months and 12 months, which were tested for a panel of matrix metalloproteinase-7 (MMP-7), by ELISA-based.We have demonstrated that an increase in serum MMP-7 levels, but not the level at any one point in time, predicts poor prognosis.
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3 years
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Collaborators and Investigators
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- gyfyy
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
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