Effects of Blueberry Juice Consumption on Cognitive Function in Healthy Older People

December 2, 2016 updated by: University of Exeter

Effects of Blueberry Juice Consumption on Brain Activation and Perfusion in Healthy Older People

Blueberries are rich in flavonoids that possess antioxidant and anti-inflammatory properties, which in rodent models are neuro-protective. The risk of developing dementia is reduced in people habitually consuming high flavonoid intakes, but data from human intervention studies is sparse. We therefore investigated whether 12 weeks of blueberry concentrate supplementation improved cognitive function in healthy elderly via increased brain activation and perfusion.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

26

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

60 years to 80 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • aged 60-80y
  • Addenbrooke's Cognitive Examination III questionnaire > 88
  • Consuming 5 or less portions of fruit per day

Exclusion Criteria:

Addenbrooke's Cognitive Examination III questionnaire < 88 Contraindications for MRI Consuming more than 5 portions of fruit per day

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Blueberry
Blueberry concentrate consumed daily for 12 weeks.
Dietary supplement: Blueberry
Placebo Comparator: Placebo
Placebo concentrate consumed daily for 12 weeks.
Dietary supplement: Placebo

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Brain perfusion
Time Frame: Change from baseline to 12 weeks dietary supplementation
MRI - arterial spin labelling
Change from baseline to 12 weeks dietary supplementation

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Brain activation
Time Frame: Change from baseline to 12 weeks dietary supplementation
fMRI whilst performing modified Stroop task
Change from baseline to 12 weeks dietary supplementation
Cognitive function tests
Time Frame: Change from baseline to 12 weeks dietary supplementation
Cogstate battery of tests
Change from baseline to 12 weeks dietary supplementation
Blood biomarkers of inflammation
Time Frame: Change from baseline to 12 weeks dietary supplementation
CRP, IL6,
Change from baseline to 12 weeks dietary supplementation
Blood biomarkers of oxidative stress
Time Frame: Change from baseline to 12 weeks dietary supplementation
protein carbonyls, glutathione
Change from baseline to 12 weeks dietary supplementation
Blood biomarkers of neurogenesis
Time Frame: Change from baseline to 12 weeks dietary supplementation
BDNF
Change from baseline to 12 weeks dietary supplementation

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Exeter

Investigators

  • Principal Investigator: Joanna Bowtell, PhD, University of Exeter

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2013

Primary Completion (Actual)

September 1, 2014

Study Completion (Actual)

September 1, 2014

Study Registration Dates

First Submitted

September 13, 2016

First Submitted That Met QC Criteria

December 2, 2016

First Posted (Estimate)

December 7, 2016

Study Record Updates

Last Update Posted (Estimate)

December 7, 2016

Last Update Submitted That Met QC Criteria

December 2, 2016

Last Verified

September 1, 2016

More Information

Terms related to this study

Other Study ID Numbers

  • 1314/134617

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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