The Neural Substrates for Working Memory Training (WMT)

January 4, 2017 updated by: Yun XiaoPing, China Rehabilitation Research Center

The Study on the Brain Mechanisms for the Rehabilitation of Working Memory Deficits in Patients With Acquired Brain Injury Using Multimodal Magnetic Resonance Imaging

This study aims to conduct a contrast study on the characteristics of functional and structural connectivity of neural networks of working memory in patients with acquired brain injury versus normal controls, using resting-state functional connectivity magnetic resonance imaging, task-specific functional magnetic resonance imaging and diffusion tensor imaging, combined with cognitive behavioral examinations. Another purpose is to reveal the characteristics of dynamic change of neural networks of working memory pre- and post-intervention in patients with working memory dysfunction.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

40

Phase

  • Phase 2
  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • China
    • Beijing
      • Beijing, Beijing, China, 100068
        • Recruiting
        • Department of Rehabilitation Evaluation, China Rehabilitation Research Center
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 55 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Right handedness
  • Diagnosis of traumatic brain injury or stroke
  • Course of disease within one year
  • The score of MoCA test > 24
  • Able to understand instructions

Exclusion Criteria:

  • Aphasia, unilateral spatial neglect, agnosia, apraxia
  • Hearing impairment or visual impairment
  • History of taking psychiatric drugs

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Working Memory Training
The subjects of experimental group received a series of working memory training, 30 min for 5 days per week during 6 weeks.
Behavioral: Working memory training
No Intervention: Non-Working Memory Training
The subjects of control group performed traditional cognitive rehabilitation without working memory training, 30 min for 5 days per week during 6 weeks.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Training-induced brain activations during working memory tasks in fMRI
Time Frame: six weeks
Training-induced increased and decreased brain activations (Number of voxels) during n-back verbal WM task compared to the pre-training baseline
six weeks

Secondary Outcome Measures

Outcome Measure
Time Frame
The fluid intelligence measured by Raven's Standard Progressive Matrices (RSPM) test
Time Frame: six weeks
six weeks
Attention ability assessed by Stroop color-word test
Time Frame: six weeks
six weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

China Rehabilitation Research Center

Investigators

  • Principal Investigator: Xiaoping Yun, MD, Department of Rehabilitation Evaluation, China Rehabilitation Research Center

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2012

Primary Completion (Anticipated)

October 1, 2018

Study Registration Dates

First Submitted

December 31, 2016

First Submitted That Met QC Criteria

January 4, 2017

First Posted (Estimate)

January 6, 2017

Study Record Updates

Last Update Posted (Estimate)

January 6, 2017

Last Update Submitted That Met QC Criteria

January 4, 2017

Last Verified

January 1, 2017

More Information

Terms related to this study

Other Study ID Numbers

  • NSFC-81272165

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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