The Glycaemic Effect of Isomaltulose Consumption in Healthy Participants

The objective of this study is to determine the glycaemic effect of isomaltulose and sucrose in Chinese, Indian, Malay, and Caucasian individuals. The current study will provide important information on the potential health benefits of isomaltulose consumption in Asian population. It will also reveal how the three main ethnicities in Singapore respond to isomaltulose and whether the response differs from the Caucasians.

Study Overview

• Status: Completed
• Conditions: Diabetes Mellitus
• Intervention / Treatment: Other: Isomaltulose; Other: Sucrose

Detailed Description

The objective of the present study is to investigate the glycaemic effect of isomaltulose in Chinese, Indians, Malays and Caucasians. This will be a single intervention. Up to fifty participants, consisting of at least ten Chinese, ten Malays, ten Indians, and ten Caucasians completed data sets, aged between 21 and 40 years will be recruited from the general public in Singapore. Participants will be asked to attend two test sessions for this study. Participants will consume either a sucrose drink or an isomaltulose drink (each containing 50 g of available carbohydrate).

• Study Type: Interventional
• Enrollment (Actual): 46
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 21 years to 40 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Chinese, Indian, Malay or Caucasian ethnic origin

Exclusion Criteria:

• People with major chronic disease such as heart disease, cancer or diabetes mellitus
• Individuals with food intolerances or allergies to isomaltulose or sucrose
• Individuals who are taking insulin or drugs known to affect glucose metabolism and body fat distribution
• People with a major medical or surgical event requiring hospitalization within the preceding 3 months
• Individuals with the presence of disease or drugs which influence digestion and absorption of nutrients
• Pregnant women

Study Plan

How is the study designed?

Design Details

• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Isomaltulose; 50g of isomaltulose dissolved in 250ml of water	Other: Isomaltulose; Isomaltulose is a disaccharide made up of one molecule glucose and fructose with a (α1-6) linkage.
Experimental: Sucrose; 50g of sucrose dissolved in 250ml of water	Other: Sucrose; Sucrose is normal table sugar

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in post prandial Blood glucose for 180 minutes period	Blood glucose obtained through finger pricks using Hemocue Glucose Analyser	180 minutes

Collaborators and Investigators

• Sponsor: Clinical Nutrition Research Centre, Singapore
• Investigators: Principal Investigator: Melvin Leow, MD, Clinical Nutrition Research Centre

Study record dates

Study Major Dates

• Study Start: December 1, 2014
• Primary Completion (Actual): September 1, 2016
• Study Completion (Actual): September 1, 2016

Study Registration Dates

• First Submitted: January 10, 2017
• First Submitted That Met QC Criteria: January 11, 2017
• First Posted (Estimate): January 13, 2017

Study Record Updates

• Last Update Posted (Estimate): January 13, 2017
• Last Update Submitted That Met QC Criteria: January 11, 2017
• Last Verified: January 1, 2017

More Information

Terms related to this study

• Other Study ID Numbers: 2014/01008

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO