Effect of Combined Fatty Acid Supplementation and Eccentric Exercise Training on Exercise Performance (FAT)

Effect of Combined Fatty Acid Supplementation and Eccentric Exercise Training on Exercise Performance, Inflammation, Gene Expression and Epigenetic Signatures

The aim of the study is to determine whether fish oil (specifically omega-3 long chain polyunsaturated fatty acids [EPA-DHA]) supplementation can enhance eccentric resistance exercise performance when combined with a resistance exercise training study. The investigators aim to establish the potential mechanisms that might mediate performance changes at a cellular level.

Study Overview

• Status: Completed
• Conditions: Exercise-induced Inflammation
• Intervention / Treatment: Dietary supplement: Fish Oil; Dietary supplement: Placebo

• Study Type: Interventional
• Enrollment (Actual): 18
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United Kingdom
  • Leicester, United Kingdom, LE11 3TU
    • Loughborough University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 55 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Males
• Healthy

Exclusion Criteria:

• Resistance exercise training within the past 6 months
• Vitamin or fish oil supplementation over the past 6 months
• Habitual use of anti-inflammatory drugs
• History of heart disease
• History of coagulation/bleeding disorder
• History of metabolic disease
• Serious allergy
• Known to have blood-borne virus
• Females (Due to differences in cell membrane incorporation of Omega-3 between the sexes and the testing schedule being unable to fit in with menstrual cycle, altering the blood markers that are being measured)
• Currently no symptoms of general illness

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Fish Oil; Fish oil 5.1g/ day - Premium Omega-3, Norwegian Pure-3, Oslo, Norway	Dietary supplement: Fish Oil; Fish Oil Capsule; Other Names: n-3 PUFA, Omega-3
Placebo Comparator: Placebo; Olive Oil 6g/ day - Premium Omega-3, Norwegian Pure-3, Oslo, Norway	Dietary supplement: Placebo; Olive Oil capsule manufactured to mimic fish oil capsule; Other Names: Olive Oil

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Strength	Quadriceps and Hamstring strength using an isokinetic dynamometer	Change from baseline strength at 11 weeks
Leg power	Dynamic leg power assessed through jump height on force platform	Change from baseline strength at 11 weeks

Collaborators and Investigators

• Sponsor: Loughborough University

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2016
• Primary Completion (Actual): December 20, 2017
• Study Completion (Actual): December 20, 2017

Study Registration Dates

• First Submitted: August 4, 2017
• First Submitted That Met QC Criteria: August 22, 2017
• First Posted (Actual): August 23, 2017

Study Record Updates

• Last Update Posted (Actual): March 27, 2018
• Last Update Submitted That Met QC Criteria: March 26, 2018
• Last Verified: March 1, 2018

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Inflammation
• Other Study ID Numbers: LoughboroughU

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No