- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03430323
Ultra Dual-Energy X-ray Absorptiometry (DXA): Accurate and Precise Quantitative Multi-compartment Body Composition (UltraDXA)
March 5, 2019 updated by: University of California, San Francisco
Ultra DXA: Accurate and Precise Quantitative Multi-compartment Body Composition
The central hypothesis is that the combination of measurements from 3D optical scans with standard DXA scans can be used to calculate 4 unique body composition compartments: water, fat, protein, mineral.
This is significant because it will allow for accurate assessment of adiposity and functional protein status independent of hydration.
The hypothesis is based on preliminary data collected demonstrating the use of thickness and dual energy X-ray measurements to calculate three-compartment breast composition.
Study Overview
Status
Completed
Conditions
Detailed Description
This is a cross-sectional comparative technology study using a sample of convenience stratified by age, sex, and BMI. Following consent, each participant will undergo:
- 6 DXA whole body scans. The primary measure is bone mineral mass and body volume. DXA body volume is measured using equations from previous work that relate the fat, lean, and bone masses to individual volumes in an image pixel using the physical densities of the components and the know area of the pixel.
- Total body water measurement using standard deuterium dilution methods. The primary measure is total body water in liters.
- Body volume measurement using air displacement plethsymography. The primary measure is volume in liters.
- Whole body 3D optical surface scans. The primary measures mesh points that make up a point cloud of the surface of the body. Approximately 500,000 mesh points are used and placed on the surface of the participants body image. The variation of the location of these mesh points can be described using Principal Component Analysis (PCA). In addition, the 3D optical scans can be used to measure the thickness of the body along the path of each X-ray that goes through the body resulting in a tissue thickness for each DXA image pixel.
- Bioelectrical impedance analysis (BIA). The primary measure is percent body fat, and total body water.
- Physical anthropometry. The primary measure is waist circumference.
Study Type
Observational
Enrollment (Actual)
33
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
California
-
San Francisco, California, United States, 94143
- University of California San Francisco
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Community sample
Description
Inclusion Criteria:
- ambulatory
- tolerate lying on their back on a table for 20 minutes
- less than 250 lbs
- tolerate standing and holding still for 1 minute
Exclusion Criteria:
- cannot stand for several minutes
- cannot lie down on a table for 10 minutes
- over 250 lbs
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Relationship between BIA and deuterium methods to measure total body water.
Time Frame: 1 Day
|
Correlation between total body water from deuterated water, versus total body water estimated from BIA. body water is directly reported by the BIA device.
|
1 Day
|
Relationship between whole body 4-C DXA and standard 4-C body fat
Time Frame: 1 Day
|
The standard 4-component model combines 4 measures (weight, DXA bone mineral mass, body volume by ADP, and body water using deuterium) into one equation to estimate body fat.
The proposed 4C-DXA method estimates pixel by pixel body fat in the DXA image by combining pixel level measures.
These measures are the low- and high-energy X-ray absorption of the tissue visualized in the pixel, and the pixel thickness measured using 3D optical tissue thickness.
When no bone is present, these three measures provide three estimates of tissue protein, fat, and water.
When bone is present, the same measures used to estimate bone, fat, and lean mass where lean is the sum of water and protein masses.
The protein/water ratio is estimated from nearest neighbor pixels that contain no bone.
This results in a description of the fat, water, protein, and mineral masses of all pixels.
Summing the pixels provides total fat.
The correlation of the standard to the proposed estimates of body fat is the outcome.
|
1 Day
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Associations of 3D optical shape and DXA percent body fat.
Time Frame: 1 Day
|
Using the mesh points that make up the image data of 3D images, one can estimate body percent fat by treating all mesh points as variables and describing their shape variance using principal component analysis (PCA).
The result of the PCA method is that it creates variables that describe the variance of all the mesh points.
The PCA variables can then be used to estimate percent body fat.
In this secondary outcome, we will compare the estimate of percent body fat using PCA variables to the percent body fat of the standard 4-compartment model.
|
1 Day
|
Standard 4C fat mass compared to simplified 4C model
Time Frame: 1-Day
|
In this secondary analysis we compare using correlation statistics the total body fat mass from the standard 4C model to that derived using a simplified whole body 4C model.
In the simplified model, BIA-estimated body water is substituted for deuterium-dilution, and a derivation of body volume using DXA for ADP body volume.
DXA can estimate body volume by first determining the total fat, lean, and bone reported for a participant, and then using the previously derived physical densities of fat, lean, and bone masses, estimate the total body volume.
The singular comparison for this aim is the correlation of standard 4C model body fat to the simplified 4C model body fat.
|
1-Day
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Principal Investigator: John A Shepherd, PhD, University of California, San Francisco
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
August 29, 2016
Primary Completion (ACTUAL)
January 1, 2018
Study Completion (ACTUAL)
January 1, 2018
Study Registration Dates
First Submitted
January 8, 2018
First Submitted That Met QC Criteria
February 5, 2018
First Posted (ACTUAL)
February 12, 2018
Study Record Updates
Last Update Posted (ACTUAL)
March 7, 2019
Last Update Submitted That Met QC Criteria
March 5, 2019
Last Verified
March 1, 2019
More Information
Terms related to this study
Other Study ID Numbers
- P0515173
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Body Composition
-
Nova Southeastern UniversityCompleted
-
Centro Universitario de Ciencias de la Salud, MexicoCompleted
-
University of Southern CaliforniaCompleted
-
University of SurreyUnknownBody Composition
-
Texas Woman's UniversityCompleted
-
Auburn UniversityCompletedBody CompositionUnited States
-
Universidad de ZaragozaUnknown
-
University Hospital, Clermont-FerrandCenter of study in Human Nutrition, INRA, Department of Clinical NutritionCompleted
-
Muğla Sıtkı Koçman UniversityBahçeşehir UniversityCompleted
-
University of Southern CaliforniaCompleted