Blood, Muscle and Exercise Responses to Sodium Bicarbonate Supplementation

Blood and Muscle Responses to Sodium Bicarbonate Supplementation and Subsequent Exercise Performance

The aim of this study is to evaluate the changes in activity of transporters of H+ (monocarboxylate transporters; MCT1, MCT4, NHE) following sodium bicarbonate supplementation and subsequent exercise performance. Fifteen healthy men (age 18-35 years) will be invited to attend the laboratory on five separate visits to a randomized, double-blind, placebo-controlled study. Participants will be supplemented with a 0.3 g/kg dose of sodium bicarbonate or placebo (Analytical Pharmacy, Brazil) in opaque gelatin capsules. One hour after supplementation they will perform a 1-km time trial and every 10 minutes a blood sample will be collected. A muscle biopsy will be taken prior to supplementation, immediately prior to exercise, and immediately post-exercise. A questionnaire will be also used to evaluate the side-effects associated with sodium bicarbonate supplementation. Muscle and blood samples will be analysed for acidity and H+ and muscle samples will be analysed for H+ transporters (MCT1, MCT4, NHE).

Study Overview

• Status: Unknown
• Conditions: Sports Nutritional Physiological Phenomena
• Intervention / Treatment: Dietary supplement: Sodium bicarbonate; Dietary supplement: Maltodextrin

• Study Type: Interventional
• Enrollment (Anticipated): 15
• Phase: Not Applicable

Contacts and Locations

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Healthy males

Exclusion Criteria:

• Smokers
• Chronic disease
• Prior or current use of steroids
• Use of creatine in the last 6 months
• Use of beta-alanine in the last 6 months

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Triple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Sodium bicarbonate; 0.3 g∙kg-1body mass of sodium bicarbonate	Dietary supplement: Sodium bicarbonate; Sodium bicarbonate in powder form ingested in gelatine capsules. This leads to an increase bicarbonate concentration in blood, increasing buffering capacity which may lead to improvements in exercise
Placebo Comparator: Placebo; Individuals will ingest 0.3 g/kg maltodextrin before undergoing exercise	Dietary supplement: Maltodextrin; Maltodextrin will be used as a placebo as it will not lead to any increases in circulating bicarbonate and, at this dose, will not likely have any physiological effect.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
H+ transporter activity	Change in activity of transporters related to H+	5 minutes Post-exercise

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Exercise performance	Change in 1 km cycling time-trial performance	1 hour Post-supplementation

Collaborators and Investigators

• Sponsor: University of Sao Paulo

Study record dates

Study Major Dates

• Study Start (Anticipated): August 1, 2019
• Primary Completion (Anticipated): November 1, 2020
• Study Completion (Anticipated): December 1, 2020

Study Registration Dates

• First Submitted: March 31, 2018
• First Submitted That Met QC Criteria: April 13, 2018
• First Posted (Actual): April 23, 2018

Study Record Updates

• Last Update Posted (Actual): June 6, 2019
• Last Update Submitted That Met QC Criteria: June 4, 2019
• Last Verified: June 1, 2019

More Information

Terms related to this study

• Keywords: Physiological Phenomena
• Other Study ID Numbers: SB_BloodMuscle

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No