- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03521817
The Effects of Alcohol Consumption on Central Adiposity (CONSUME)
The Effects of Alcohol Consumption on Central Adiposity and Testosterone Following Weight Loss in Obese, Pre-menopausal Women
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Alcohol (i.e. ethanol) is one of the most widely used recreational substances by humans and is consumed regularly by much of the U.S. population. Despite the high prevalence of alcohol intake, the metabolic health effects associated with use have not been firmly established. There is a paucity of data from longitudinal studies in humans that examine the metabolic response to routine alcohol consumption in a randomized controlled trial (RCT).
This is a novel pilot study to examine, for the first time, the effects of ethanol consumption on fat distribution and testosterone during weight loss in a RCT. Findings from this study would provide insight into an interesting and unanswered question -- does routine alcohol intake exert unfavorable health effects despite the expected beneficial outcomes of caloric restriction and weight loss? This research may provide new knowledge of the metabolic outcomes resulting from alcohol intake and pathways that may be involved leading to potential new therapeutic targets of treatment.
The objective of the proposed study is to enroll women with obesity that will undergo a controlled, energy restricted feeding intervention to test the effects of chronic ethanol consumption on adipose distribution and circulating testosterone during weight loss. Women will be randomized to an ethanol-free control group or an ethanol-consuming group, and all will consume 30% energy-restricted diets.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Louisiana
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Baton Rouge, Louisiana, United States, 70808
- Pennington Biomedical Research Center
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- - Pre-menopausal women only
- 21-40 years of age
- BMI 27-50 kg/m2 (+/- 0.5 will be accepted)
- Must practice and be willing to continue to practice appropriate birth control (defined as a method which results in a low failure rate, i.e., less than 1% per year, when used consistently and correctly, such as double barrier methods [male condom with spermicide, with or without cervical cap or diaphragm], implants, intrauterine contraceptive devices, tubal ligation (surgically sterile), abstinence, or in an established relationship with a vasectomized or same sex partner) during the entire duration of the study
- Must be willing to adhere to all study procedures, including consumption of all study foods and beverages and attendance at all study visits
- - Must be willing to eat at least one meal at PBRC 3 times per week on weekdays (excluding holidays)
- Must be willing to consume alcohol
- Must be willing to abstain from alcohol for 8-weeks if randomized to non-alcohol control group.
- Must be a daily, or almost daily drinker, defined as typically consuming at least 8 drinks per week, but no more than 4 per day
- Must be willing to undergo an overnight alcohol test (at home) of ethanol at the proposed dose before enrollment in the study
- Must have access to a device that can be used for video monitoring of compliance (i.e. Skype)
- Must be willing to have your blood stored for future research
Exclusion Criteria:
- - Non-drinkers of alcohol
- Habitual binge drinkers, as defined by the consumption of ≥ 4 standard drinks per day or ≥ 28 drinks per week.
- Self-reported alcoholics or a history of alcoholism
- Have a 1st degree relative with alcoholism
- Any attendance or inpatient stay for alcohol or drug treatment
- Display any characteristics of current or future substance abuse disorders
- Presence of any psychiatric, behavioral, or medical disorder that, in the opinion of the PIs, Co-I, or MI, may interfere with study participation, the ability to adhere to the protocol, or has the potential for increased substance abuse
- Prescription medications that interact with alcohol intake
- Abnormal screening laboratory safety tests
- Smokers
- Diagnosis of Type 1 or 2 diabetes mellitus, cancer, or major organ disease
- Serious digestive disorders
- Conditions that affect metabolism or body weight (i.e. uncontrolled thyroid conditions, bariatric surgery, pregnancy, breastfeeding)
- Partial and/or full hysterectomy
- Hormonal pharmaceutical contraceptives including oral contraception (birth control pills), injectables (Depo-Provera), or the patch (Xulane)
- PCOS
- Use of medications that affect body weight or metabolism (i.e. atypical antipsychotics, weight loss medications).
- Not willing to store biospecimens for future use
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Alcohol
Etoh will have a 30% reduction in calories from weight maintenance and will consume the same percentage of each traditional macronutrient (20% protein, 50% carbohydrate, and 30% fat; (minus the ~240 kcals from ethanol).
The Etoh group will consume a 30% energy restriction diet that will also include ~2.5 standard drinks, or 35 grams of ethanol, administered as 80-proof distilled spirits (e.g.
80 proof gin, rum, vodka, whiskey, or tequila).
|
The ethanol group will consume a 30% energy restriction diet that will also include ~2.5 standard drinks, or 35 grams of ethanol, administered as 80-proof distilled spirits (e.g.
80 proof gin, rum, vodka, whiskey, or tequila).
In the United States, one "standard" drink contains roughly 14 grams of pure alcohol.
Other Names:
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Active Comparator: No Alcohol
No Etoh will have a 30% reduction in calories from weight maintenance and will consume the same percentage of each traditional macronutrient (20% protein, 50% carbohydrate, and 30% fat).
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This group will not consume alcohol.
Thus 0 kcal/d will come from alcohol
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Central (Abdominal) Adiposity
Time Frame: 8 weeks
|
change in visceral abdominal adipose tissue from baseline to post intervention
|
8 weeks
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2017-057
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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