Plasticity of Neonatal Neuronal Networks in Very Premature Infants: Source Localization of Temporal Theta Activity, the First Endogenous Neural Biomarker, in Temporoparietal Areas

Plasticity of Neonatal Neuronal Networks Temporal Theta Activity, the First Endogenous

Sponsors

Lead sponsor: Centre Hospitalier Universitaire, Amiens

Source Centre Hospitalier Universitaire, Amiens
Brief Summary

Temporal theta slow-wave activity (TTA-SW) in premature infants is a specific signature of the early development of temporal networks, as it is observed at the turning point between non-sensory driven spontaneous local processing and cortical network functioning. The role in development and the precise location of TTA-SW remain unknown. Previous studies have demonstrated that preterms from 28 weeks of gestational age (wGA) are able to discriminate phonemes and voice, supporting the idea of a prior genetic structural or activity-dependent fingerprint that would prepare the auditory network to compute auditory information at the onset of thalamocortical connectivity. They recorded TTA-SW in 26-32 wGA preterms. The rate of TTA-SW in response to click stimuli was evalu- ated using low-density EEG in 30 preterms. The sources of TTA-SW were localized by high-density EEG using different tissues conductivities, head models and mathematical models.

Detailed Description

Temporal theta slow-wave activity (TTA-SW) in premature infants is a specific signature of the early development of temporal networks, as it is observed at the turning point between non-sensory driven spontaneous local processing and cortical network functioning. The role in development and the precise location of TTA-SW remain unknown. Previous studies have demonstrated that preterms from 28 weeks of gestational age (wGA) are able to discriminate phonemes and voice, supporting the idea of a prior genetic structural or activity-dependent fingerprint that would prepare the auditory network to compute auditory information at the onset of thalamocortical connectivity. They recorded TTA-SW in 26-32 wGA preterms. The rate of TTA-SW in response to click stimuli was evalu- ated using low-density EEG in 30 preterms.

Overall Status Completed
Start Date July 1, 2016
Completion Date January 1, 2017
Primary Completion Date January 1, 2017
Study Type Observational
Primary Outcome
Measure Time Frame
specific temporal TTA-SW 2 months
Enrollment 28
Condition
Intervention

Intervention type: Other

Intervention name: ElectroEncephaloGraphy

Description: Density ElectroEncephaloGraphy analysis

Eligibility

Sampling method: Non-Probability Sample

Criteria:

Inclusion Criteria:

- healthy premature infants

- Gestational Ages of 26 and 32 wGA

Exclusion Criteria:

- unhealthy premature infants

Gender: All

Minimum age: N/A

Maximum age: N/A

Healthy volunteers: No

Overall Official
Last Name Role Affiliation
Fabrice Wallois, MD, PhD Principal Investigator CHU AMIENS
Verification Date

September 2018

Responsible Party

Responsible party type: Sponsor

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Arm group label: 13 high

Description: High-Density ElectroEncephaloGraphy analysis of 13 healthy premature infants

Arm group label: 15 low

Description: Low-Density ElectroEncephaloGraphy analysis of other 15 healthy premature infants

Acronym NEURONAUX
Patient Data No
Study Design Info

Observational model: Case-Only

Time perspective: Retrospective

Source: ClinicalTrials.gov