Power Production in Older Adults With Knee Osteoarthritis

Power Production in Older Adults With Knee Osteoarthritis Compared to Healthy Counterparts

Knee osteoarthritis is an important cause of functional disabilities at old age. Previous research has demonstrated that individuals with knee osteoarthritis have reduced knee-extensor strength in comparison to healthy individuals. However, rapid power production declines more than strength as a consequence of ageing and is more predictive of functional capacity. However, limited research has investigated whether individuals with knee osteoarthritis have reduced ability to develop strength and power rapidly on top of reduced maximal strength capacities, which is the primary aim of the current study.

Study Overview

• Status: Completed
• Conditions: Osteo Arthritis Knee
• Intervention / Treatment: Diagnostic test: Muscle function test

• Study Type: Observational
• Enrollment (Actual): 48

Contacts and Locations

Study Locations

• Belgium
  • Leuven, Belgium, 3001
    • Department of Movement Sciences

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years to 80 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Adults between 50 and 80 years with or without knee osteoarthritis. Subjects are sedentary or recreationally active.

Description

Inclusion Criteria:

Group with knee osteoarthritis:

- Diagnosed with knee osteoarthritis based on RX.

Exclusion Criteria:

Healthy group:

• Systematic engagement in (resistance) exercise in the 12-months prior to participation
• Cardiovascular disease
• Neurological disorders
• Cognitive malfunctioning
• Severe knee or hip problems

Group with knee osteoarthritis:

• Systematic engagement in (resistance) exercise in the 12-months prior to participation
• Cardiovascular disease
• Neurological disorders
• Cognitive malfunctioning
• Severe hip problems

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Older adults with knee osteoarthritis (>50 years)	Diagnostic test: Muscle function test; Power and strength tests of the knee-extensor muscles, handgrip strength, functional capacity tests
Healthy older adults (> 50 years)	Diagnostic test: Muscle function test; Power and strength tests of the knee-extensor muscles, handgrip strength, functional capacity tests

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Rate of power development	Subjects perform a test protocol on a Biodex dynamometer, consisting of isotonic contractions of the leg-extensor muscles. Subjects are instructed to kick as fast as possible against different (relative) loads. The rate of power development (watt/s) is defined as the linear slope of the power-time curve and is measured from the onset of movement till peak power.	up to 3 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Maximal isometric strength	Maximal strength (Nm) is measured by means of unilateral isometric knee-extensor tests on a Biodex dynamometer.	up to 3 months
Maximal isokinetic strength	Maximal strength (Nm) is measured by means of unilateral isokinetic knee-extensor tests on a Biodex dynamometer.	up to 3 months
Stair Climbing performance	Stair ascent duration (in s), the time needed to ascent a flight of stairs.	up to 3 months
Gait speed	The average speed to walk 10m as fast as possible (in m/s).	up to 3 months
5 repetition sit-to-stand test	The time needed to perform 5 sit-to-stand transitions (in s).	up to 3 months
Timed-up-and-go	The time needed to stand up from a chair, walk 3m, turn, walk back and sit down.	up to 3 months
Handgrip strength	Handgrip strength (kg) evaluated with Jamar dynamometer.	up to 3 months

Collaborators and Investigators

• Sponsor: KU Leuven

Study record dates

Study Major Dates

• Study Start (ACTUAL): September 1, 2018
• Primary Completion (ACTUAL): December 20, 2018
• Study Completion (ACTUAL): December 20, 2018

Study Registration Dates

• First Submitted: September 18, 2018
• First Submitted That Met QC Criteria: September 20, 2018
• First Posted (ACTUAL): September 21, 2018

Study Record Updates

• Last Update Posted (ACTUAL): February 8, 2019
• Last Update Submitted That Met QC Criteria: February 7, 2019
• Last Verified: February 1, 2019

More Information

Terms related to this study

• Keywords: Knee osteoarthritis; functional capacity; power production
• Additional Relevant MeSH Terms: Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Arthritis; Osteoarthritis; Osteoarthritis, Knee
• Other Study ID Numbers: S60595

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No