Clinical Study of Titrating PEEP of Different Methods on Right Heart Function

Clinical Study of Titrating PEEP of Different Methods on Right Heart Function and Pulmonary Artery Pressure in ARDS Patients

To observe the influence of different methods titrating PEEP on right heart function and pulmonary artery pressure in ARDS patients .

Study Overview

• Status: Unknown
• Conditions: ARDS, Human

Detailed Description

30 patients who diagnosed as ARDS were included in this study.Then set PEEP with respectively ARDS net 、EIT and Esophageal Pressure in Breathing Machine . Recorded diameter of right and left ventricular TAM TAPSE pulmonary artery pressure.Objective to evaluate the correlation between the level of PEEP in three methods and the right heart function and pulmonary artery pressure in ARDS patients .

• Study Type: Observational
• Enrollment (Anticipated): 30

Contacts and Locations

Study Locations

• China
  • Jiangsu
    • Nanjing, Jiangsu, China, 210009
      • Recruiting
      • Zhongda hospital
      • Contact: Feng Mei Guo, Dr; Phone Number: 13813841261; Email: 13813841261@139.com
      • Principal Investigator: FengMei Guo, Dr

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 80 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Population admitted to ICU of Zhongda hospital，diagnosed of medium or serious ARDS。

Description

Inclusion Criteria:

• Patients admitted to ICU diagnosed of modecate to severe ARDS (Berlin criteria)
• Patients age between 18 years old and 80 years

Exclusion Criteria:

• Patients with chronic respiratory diseases such as COPD.
• Ventilated because of oesophageal surgery in the previous 12months.
• Patients who cannot obtain clear ultrasound images due to thoracic surgery ,massive pleural effusion.
• Oesophageal bleeding in previous 30 days history of oesophageal varices.
• Facial trauma and surgery.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
the function of right heart and pulmonary artery pressure	Systolic Pulmonary Artery Pressure TAPSE or Tricuspid Annular Motion orTricuspid annular plane systolic excursion or right ventricular diameter or right left ventricular diameter ratio in diffrient PEEP	2018.4-2019.3

Collaborators and Investigators

• Sponsor: Southeast University, China
• Collaborators: Zhongda Hospital
• Investigators: Principal Investigator: Chun Pan, Dr, Southeast university

Study record dates

Study Major Dates

• Study Start (ACTUAL): August 4, 2018
• Primary Completion (ANTICIPATED): March 30, 2019
• Study Completion (ANTICIPATED): March 30, 2019

Study Registration Dates

• First Submitted: October 11, 2018
• First Submitted That Met QC Criteria: February 17, 2019
• First Posted (ACTUAL): February 19, 2019

Study Record Updates

• Last Update Posted (ACTUAL): February 19, 2019
• Last Update Submitted That Met QC Criteria: February 17, 2019
• Last Verified: February 1, 2019

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Respiration Disorders; Lung Diseases; Respiratory Distress Syndrome
• Other Study ID Numbers: ARDS

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No