Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements

This investigations examined the effect that posture has on metabolic and cardiovascular measurements. Further, it will explore the potential for body weight status or physical activity to influence these relationships. All subjects will complete a seated condition and a standing condition in a counterbalanced manner.

Study Overview

• Status: Enrolling by invitation
• Conditions: Overweight and Obesity
• Intervention / Treatment: Behavioral: sit/stand

Detailed Description

The purpose of the present study was to evaluate both metabolic and cardiovascular responses to acute bouts of computer work while sitting and standing. Cardiovascular measurements were made using continuous non-invasive blood pressure monitoring and metabolic measurements were made using indirect calorimetry. Subjects will be grouped and analyzed based upon the weight status of the subject. All subjects will complete a seated condition and a standing condition in a counterbalanced manner. Investigators hypothesize that metabolic and cardiovascular responses will be elevated in the standing condition compared to sitting.

• Study Type: Observational
• Enrollment (Estimated): 80

Contacts and Locations

Study Locations

• United States
  • New Jersey
    • Montclair, New Jersey, United States, 07043
      • Montclair State University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 50 years (Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

Healthy subjects between the ages of 18 and 50 years.

Description

Inclusion Criteria:

• healthy adult

Exclusion Criteria:

• Have a history of cancer, cardiac issues, hypertension, pulmonary disease, stroke, neurological or muscular dystrophy, uncontrolled diabetes, or any life threatening chronic conditions.
• Are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases.
• Are unable or unwilling to stand in one position continuously for 15-20 minutes at a time.
• Use nicotine products, or non-contraceptive hormonal therapy (birth control is okay).
• Are pregnant or trying to become pregnant.
• Are not between 18 and 50 years of age.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Normal Weight; Group is determined based upon subjects weight status. Subjects will preform computer work in the seated and standing position in a counterbalanced manner while metabolic and cardiovascular measurements are made.	Behavioral: sit/stand; Subjects will be asked to both sit and stand during a single trial.
Overweight/Obese; Group is determined based upon subjects weight status. Subjects will preform computer work in the seated and standing position in a counterbalanced manner while metabolic and cardiovascular measurements are made.	Behavioral: sit/stand; Subjects will be asked to both sit and stand during a single trial.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Heart Rate	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure heart rate based upon beat-by-beat finger pressure.	Approximately 15 minutes in each condition (sitting and standing)
Systolic Blood Pressure (SBP)	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure SBP based upon beat-by-beat finger pressure.	Approximately 15 minutes in each condition (sitting and standing)
Diastolic Blood Pressure (DBP)	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure DBP based upon beat-by-beat finger pressure.	Approximately 15 minutes in each condition (sitting and standing)
Oxygen Consumption	Oxygen consumption will be measured using indirect calorimetry.	Approximately 15 minutes in each condition (sitting and standing)
Carbon Dioxide Production	Carbon Dioxide will be measured using indirect calorimetry.	Approximately 15 minutes in each condition (sitting and standing)
Ventilation	Ventilation will be measured using indirect calorimetry.	Approximately 15 minutes in each condition (sitting and standing)
Respiratory Exchange Ration (RER)	RER will be calculated using oxygen and carbon dioxide value measure from indirect calorimetry.	Approximately 15 minutes in each condition (sitting and standing)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Height	Standard stadiometer will be used to measure height in meters.	1 minute
Weight	Standard scale will be used to measure weight in kilograms.	1 minute
Body Mass Index (BMI)	Height in meters and weight in kilograms will be used to calculate BMI using the formula BMI = kg/m^2.	1 minute
Body Composition	Body composition will be measured using air displacement plethysmography.	Approximately 15 minutes
Total Peripheral Resistance (TPR)	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be uses to estimate TPR based upon beat-by-beat finger pressure.	Approximately 15 minutes in each condition (sitting and standing)
Stroke Volume	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate TPR based upon beat-by-beat finger pressure.	Approximately 15 minutes in each condition (sitting and standing)
Cardiac Output (Q)	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate Q based upon beat-by-beat finger pressure.	Approximately 15 minutes in each condition (sitting and standing)
Muscle Oxygen Saturation	Using Near-inferred spectroscopy muscle oxygen consumption will be monitored.	Approximately 15 minutes in each condition (sitting and standing)

Collaborators and Investigators

• Sponsor: Montclair State University

Publications and helpful links

General Publications

• Hosick PA, Willett JM, Matthews EL. Cardiovascular strain and metabolic rate are higher following 15 minutes of standing versus seated computer work. Eur J Prev Cardiol. 2020 Dec;27(19):2131-2133. doi: 10.1177/2047487319867402. Epub 2019 Jul 29. No abstract available.

Helpful Links

• Link to article

Study record dates

Study Major Dates

• Study Start (Actual): November 11, 2018
• Primary Completion (Estimated): May 15, 2028
• Study Completion (Estimated): May 15, 2028

Study Registration Dates

• First Submitted: April 22, 2019
• First Submitted That Met QC Criteria: April 24, 2019
• First Posted (Actual): April 25, 2019

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: January 29, 2025
• Last Verified: October 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Nutrition Disorders; Overnutrition; Body Weight; Overweight
• Other Study ID Numbers: 17-18-861

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No